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Effects of maternal methyl donor on the pork characteristics of offspring pigs with prenatal exposure to bisphenol A

Published online by Cambridge University Press:  25 October 2017

Y. Zhuo ,
J. Wang ,
H. Liu ,
D. Mou ,
T. Adebowale ,
L. Che ,
Z. Fang ,
S. Xu ,
G. Liu  and
Y. Lin
...Show all authors
Y. Zhuo
Affiliation:
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, People’s Republic of China
J. Wang
Affiliation:
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, People’s Republic of China
H. Liu
Affiliation:
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, People’s Republic of China
D. Mou
Affiliation:
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, People’s Republic of China
T. Adebowale
Affiliation:
Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan 410125, People’s Republic of China
L. Che
Affiliation:
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, People’s Republic of China
Z. Fang
Affiliation:
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, People’s Republic of China
S. Xu
Affiliation:
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, People’s Republic of China
G. Liu
Affiliation:
Key Laboratory of Agro-ecological Processes in Subtropical Region, Institute of Subtropical Agriculture, Chinese Academy of Sciences, Hunan 410125, People’s Republic of China
Y. Lin
Affiliation:
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, People’s Republic of China
B. Feng
Affiliation:
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, People’s Republic of China
N. Abdullah Al-Dhabi
Affiliation:
Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
J. Li
Affiliation:
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, People’s Republic of China
V. Duraipandiyan
Affiliation:
Department of Botany and Microbiology, Addiriyah Chair for Environmental Studies, College of Science, King Saud University, Riyadh 11451, Saudi Arabia
D. Wu*
Affiliation:
Institute of Animal Nutrition, Sichuan Agricultural University, Chengdu, Sichuan 611130, People’s Republic of China
*
†E-mail: sow_nutrition@sina.com; pig2pig@sina.com
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Abstract

To explore the effects of maternal nutrition on offspring muscle characteristics, a total of 56 sows were assigned to one of the four dietary groups during gestation: control (CON), or control diets supplemented with methyl donor (MET), bisphenol A (BPA), and combined BPA and MET (BPA+MET). Compared with CON offspring, MET offspring showed a higher meat redness value, but lower glycogen content in the longissimus thoracis (LT). Moreover, compared with CON offspring, MET offspring showed lower LT glycogen synthase (GS) mRNA levels at birth and the finishing stage, and increased methylation at the GS promoter. Prenatal BPA exposure reduced the pH and redness value of meat, but increased the lightness value, lactate content, glycolytic potential and lactate dehydrogenase (LDH) enzyme activity in the LT muscle. Prenatal BPA exposure increased LDH mRNA levels in the LT muscle at birth and the finishing stage, and reduced methylation at the LDH promoter. Thus, maternal MET affects muscle GS and LDH expression via DNA methylation, thereby resulting in persistent effects on pork quality.

Keywords

methyl donorbisphenol Asowsmeat qualitymethylation
Type
Research Article
Information
animal , Volume 12 , Issue 6 , June 2018 , pp. 1306 - 1315
Copyright
© The Animal Consortium 2017 

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Footnotes

a

Yong Zhuo and Jun Wang contributed equally to this work.

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