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Extensions of the causal framework to Mendelian randomisation and gene–environment interaction

Published online by Cambridge University Press:  11 September 2023

Claire M. A. Haworth Open the ORCID record for Claire M. A. Haworth [Opens in a new window]  and
Robyn E. Wootton Open the ORCID record for Robyn E. Wootton [Opens in a new window]
Claire M. A. Haworth
Affiliation:
School of Psychological Science, University of Bristol, Bristol, UK claire.haworth@bristol.ac.uk https://www.bristol.ac.uk/people/person/Claire-Haworth-04ed5882-f1f6-4fb5-8960-5581b0cc8bc4/ robyn.wootton@bristol.ac.uk
Robyn E. Wootton
Affiliation:
School of Psychological Science, University of Bristol, Bristol, UK claire.haworth@bristol.ac.uk https://www.bristol.ac.uk/people/person/Claire-Haworth-04ed5882-f1f6-4fb5-8960-5581b0cc8bc4/ robyn.wootton@bristol.ac.uk Nic Waals Institute, Lovisenberg Diaconal Hospital, Oslo, Norway https://app.cristin.no/persons/show.jsf?id=1265206
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Abstract

In our commentary we ask whether we should ultimately endeavour to find the deep causes of behaviours? Then we discuss two extensions of the proposed framework: (1) Mendelian randomisation and (2) hypothesis-free gene–environment interaction (leveraging heterogeneity in genetic associations). These complementary methods help move us towards second-generation causal knowledge, ultimately understanding mechanistic pathways and identifying more effective intervention targets.

Type
Open Peer Commentary
Information
Behavioral and Brain Sciences , Volume 46 , 2023 , e192
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Copyright
Copyright © The Author(s), 2023. Published by Cambridge University Press

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