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The association between dietary insulin index and dietary insulin load with rheumatoid arthritis

Published online by Cambridge University Press:  29 November 2023

Mohadeseh Soleimani Damaneh Open the ORCID record for Mohadeseh Soleimani Damaneh [Opens in a new window] ,
Naheed Aryaeian ,
Shole Khajoenia ,
Leila Azadbakht Open the ORCID record for Leila Azadbakht [Opens in a new window]  and
Fatemeh Sadat Hosseini-Baharanchi
Mohadeseh Soleimani Damaneh
Affiliation:
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Naheed Aryaeian*
Affiliation:
Department of Nutrition, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
Shole Khajoenia
Affiliation:
Department of Clinical Science, Faculty of Medicine, Medical Science University, Jiroft, Iran
Leila Azadbakht
Affiliation:
Department of Community Nutrition, School of Nutritional Sciences and Dietetics, Tehran University of Medical Sciences, Tehran, Iran Diabetes Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
Fatemeh Sadat Hosseini-Baharanchi
Affiliation:
Department of Biostatistics, School of Public Health, Iran University of Medical Sciences, Tehran, Iran
*
*Corresponding author: Dr N. Aryaeian, email aryaeian.n@iums.ac.ir
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Abstract

This study was designed to assess the relationship between dietary insulin index (DII) and dietary insulin load (DIL) and rheumatoid arthritis (RA) risk in a case–control study. This study enrolled ninety-five newly diagnosed RA patients and 200 age- and sex-matched healthy controls. Dietary intakes were assessed using a validated 168-item semi-quantitative FFQ. DII and DIL were calculated using food insulin index values from previously published data. In the unadjusted model, individuals in the highest DIL tertile had the significantly higher odds of RA than those in the lowest tertile of the DIL scores (OR = 1·32, 95 % CI (1·15, 1·78), Pfor trend = 0·009). After adjusting for confounders, the risk of RA was 2·73 times higher for participants in the highest tertile of DIL than for those in the lowest tertile (OR = 2·73, 95 % CI (1·22, 3·95), Pfor trend < 0·001). In addition, patients in the highest DII tertile had higher risk of RA than those in the first tertile (OR = 2·22, 95 % CI (1·48, 3·95), Pfor trend = 0·008). This association persisted after adjusting for potential confounders (OR = 3·75, 95 % CI (3·18, 6·78), Pfor trend = 0·002). Our findings suggest that diets high in DII and DIL may increase the risk of developing RA, independent of other potential confounders. These findings can be verified by more research, particularly with a prospective design.

Keywords

Dietary insulin load (DIL)Dietary insulin index (DII)Rheumatoid arthritisCase–control
Type
Research Article
Information
British Journal of Nutrition , Volume 131 , Issue 7 , 14 April 2024 , pp. 1158 - 1165
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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