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Chromium supplementation in impaired glucose tolerance of elderly: effects on blood glucose, plasma insulin, C-peptide and lipid levels

Published online by Cambridge University Press:  09 March 2007

Matti I. J. Uusitupa ,
Leena Mykkänen ,
Onni Siitonen ,
Markku Laakso ,
Helena Sarlund ,
Päivi Kolehmainen ,
Tiina Räsänen ,
Jorma Kumpulainen  and
Kalevi Pyörälä
Matti I. J. Uusitupa
Affiliation:
Department of Clinical NutritionUniversity of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland
Leena Mykkänen
Affiliation:
Department of Medicine, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland
Onni Siitonen
Affiliation:
Department of Medicine, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland
Markku Laakso
Affiliation:
Department of Medicine, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland
Helena Sarlund
Affiliation:
Department of Medicine, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland
Päivi Kolehmainen
Affiliation:
Department of Medicine, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland
Tiina Räsänen
Affiliation:
Department of Medicine, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland
Jorma Kumpulainen
Affiliation:
Central Laboratory, Agricultural Research Centre of Finland, Jokioinen, Finland
Kalevi Pyörälä
Affiliation:
Department of Medicine, University of Kuopio, P.O. Box 1627, 70211 Kuopio, Finland
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Abstract

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Altogether twenty-six elderly subjects (aged 65–74 years) with persistent impaired glucose tolerance (World Health Organization (1985) criteria) identified in a population-based study, were randomly treated either with chromium-rich yeast (160 μg Cr/d) or with placebo for 6 months. The 24 h urinary Cr increased from 0.13 (se 0.03) to 0.40 (se 0.06) μg/d in the Cr group (n 13) but no change was found in the placebo group (n 11) (0.13 (se 0.02) v. 0.11 (se 0.02) μg/d). No significant change was observed in the oral glucose tolerance test (glucose dose 75 g; 0, 1 and 2 h blood glucose respectively): 5.3 (se 0.1), 9.3 (se 0.3), 8.2 (se 0.3) mmol/l v. 5.0 (se 0.1), 8.5 (se 0.4), 7.3 (se 0.5) mmol/l in the Cr group; 4.9 (se 0.2), 9.2 (se 0.6), 8.1 (se 0.3) mmol/l v. 4.8 (se 0.2), 8.5 (se 0.5), 7.0 (se 0.6) mmol/l in the placebo group (baseline v. 6 months). Glycosylated haemoglobin, plasma insulin, C-peptide and apolipoprotein Al and B levels remained unchanged, and no improvement was seen in serum total cholesterol (6.2 (se 0.3) v. 6.4 (se 0.3) mmol/l for the Cr group, 6.2 (se 0.4) v. 6.5 (se 0.3) mmol/l for the placebo group), high-density-lipoprotein-cholesterol (1.1 (se 0.1) v. 1.2 (se 0.1) mmol/l for the Cr group, 1.0 (se 0.1) v. 1.1 (se 0.1) mmol/l for the placebo group) or triacylglycerols (2.5 (se 0.4) v. 2.0 (se 0.4) mmol/l for the Cr group, 2.4 (se 0.2) v. 2.5 (se 0.2) mmol/l for the placebo group). The present results indicate that Cr supplementation does not improve glucose tolerance or serum lipid levels in elderly subjects with stable impaired glucose tolerance.

Keywords

ChromiumImpaired glucose toleranceInsulinC-peptideSerum peptide
Type
Chromium and Carbohydrate Metabolism
Information
British Journal of Nutrition , Volume 68 , Issue 1 , July 1992 , pp. 209 - 216
Copyright
Copyright © The Nutrition Society 1992

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