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The effect of curcumin supplementation on circulating adiponectin and leptin concentration in adults: a GRADE-assessed systematic review and meta-analysis of randomised controlled trials

Published online by Cambridge University Press:  20 November 2023

Vali Musazadeh Open the ORCID record for Vali Musazadeh [Opens in a new window] ,
Shaghayegh Abbasi ,
Zeynab Kavyani ,
Amir Hossein Moridpour ,
Diba Safarzadeh ,
Zahra Moradi ,
Fatemeh Bahadori  and
Amir Hossein Faghfouri
Vali Musazadeh
Affiliation:
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
Shaghayegh Abbasi
Affiliation:
Department of Pharmacy, Shahid Sadoughi University of Medical Sciences, Yazd, Iran
Zeynab Kavyani
Affiliation:
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
Amir Hossein Moridpour
Affiliation:
Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran School of Nutrition and Food Science, Tabriz University of Medical Sciences, Tabriz, Iran
Diba Safarzadeh
Affiliation:
Vocational School of Health Service, Near East University, Nicosia, Cyprus
Zahra Moradi
Affiliation:
Institute of Public Health and Clinical Nutrition, University of Eastern Finland, Joensuu, Finland
Fatemeh Bahadori*
Affiliation:
Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran
Amir Hossein Faghfouri*
Affiliation:
Maternal and Childhood Obesity Research Center, Urmia University of Medical Sciences, Urmia, Iran
*
*Corresponding authors: Amir Hossein Faghfouri, email Amir.nut89@gmail.com; Fatemeh Bahadori, email fbahadory27@yahoo.com
*Corresponding authors: Amir Hossein Faghfouri, email Amir.nut89@gmail.com; Fatemeh Bahadori, email fbahadory27@yahoo.com
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Abstract

Curcumin is a phytocompound found in the root of turmeric, a common herbal ingredient in many Asian cuisines. The compound contains anti-inflammatory activity, which is mediated through an upregulation of adiponectin and reduction of leptin. Results of randomised controlled trials (RCT) have shown that the effects of curcumin on adipokines are conflicting. Therefore, the current systematic review and meta-analysis of RCT were conducted with the aim of elucidating the role of curcumin supplementation on serum adiponectin and leptin. The search included PubMed, Embase, Cochrane Library, Scopus, Web of Science and Google Scholar from inception to August 2023. For net changes in adipokines, standardised mean differences (SMD) were calculated using random effects models. Thirteen RCT with fourteen treatment arms were eligible for inclusion in this meta-analysis. Curcumin supplementation was effective in increasing serum adiponectin (SMD = 0·86, 95 % CI (0·33, 1·39), P < 0·001; I2 = 93·1 %, P < 0·001) and reducing serum leptin (SMD = −1·42, 95 % CI (−2·29, −0·54), P < 0·001; I2 = 94·7 %, P < 0·001). In conclusion, curcumin supplementation significantly increased circulating adiponectin and decreased leptin levels in adults.

Keywords

CurcuminAdipokineLeptinAdiponectinMeta-analysis
Type
Systematic Review and Meta-Analysis
Information
British Journal of Nutrition , Volume 131 , Issue 6 , 28 March 2024 , pp. 964 - 973
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Copyright
© The Author(s), 2023. Published by Cambridge University Press on behalf of The Nutrition Society

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Footnotes

†

These authors contributed equally to this work and share their first authorship.

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