Hostname: page-component-848d4c4894-wg55d Total loading time: 0 Render date: 2024-05-18T16:43:46.476Z Has data issue: false hasContentIssue false

A pilot study of vitamin B12 in the treatment of tiredness

Published online by Cambridge University Press:  09 March 2007

F. R. Ellis
Affiliation:
Department of Pathology, Kindston and Long Grove Group Hospitals, 37 Coombe Road, Kingston upon Thames, Surrey TK2 7BD
S. Nasser
Affiliation:
Department of Pathology, Kindston and Long Grove Group Hospitals, 37 Coombe Road, Kingston upon Thames, Surrey TK2 7BD
Rights & Permissions [Opens in a new window]

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.

1. Twenty-eight subjects complaining of tiredness completed a double-blind cross-over trial of injections of hydroxocobalamin (5 mg twice weekly for 2 weeks) followed by a rest period of 2 weeks and then a similar course of matching placebo injections. Symptoms were assessed by a daily self-rating method and included appetite, mood, energy, sleep and general feeling of well-being.

2. Those subjects who received the placebo in the first 2-week period showed a favourable response to hydroxocobalamin in the second period in all measurements made. The response achieved statistical significance (P = 0·006) in respect of general well-being; ‘happiness’ achieved a value of P = 0·032. Subjects who received hydroxocobalamin in the first period showed no difference between responses to active and placebo treatments, which suggests that the effects of the vitamin may persist for a period of at least 4 weeks.

Type
Clinical and Human Nutrition
Copyright
Copyright © The Nutrition Society 1973

References

Chanarin, I. & Berry, V. (1964). J. clin. Path. 175, 111.CrossRefGoogle Scholar
Ellis, R. F., Nasser, S. & Wrighton, R. J. (1970). Practitioner 204, 838.Google Scholar
Foulds, W. S., Chisholm, J. A., Bronte Stewart, J. & Wilson, T. M. (1969). Br. J. Opthal. 54, 393.CrossRefGoogle Scholar
Morwood, J. M. B. (1952). Practitioner 168, 67.Google Scholar
O'Brien, J. R. (1954). Br. med. J. ii, 136.CrossRefGoogle Scholar
Spray, G. H. (1955). Clin. Sci. 14, 661.Google Scholar
Westergren, A. (1921). Acta med. scand. 54, 247.CrossRefGoogle Scholar
Wilkinson, J. F. (1968). Practitioner 200, 841.Google Scholar