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Ulcerative dermatitis in rats with over fifteen generations of protein malnutrition

Published online by Cambridge University Press:  09 March 2007

Janina R. Galler ,
J. G. Fox ,
J. C. Murphy  and
D. E. Melanson
Janina R. Galler
Affiliation:
Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J. G. Fox
Affiliation:
Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
J. C. Murphy
Affiliation:
Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
D. E. Melanson
Affiliation:
Department of Nutrition and Food Science, Massachusetts Institute of Technology, Cambridge, Massachusetts 02139, USA
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Abstract

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1. Male and female rats with histories of up to twenty generations of protein malnutrition were found to be at a higher risk for the development of ulcerative dermatitis than rats maintained on a low-protein diet for one generation or in controls on an adequate-protein intake.

2. In all groups, female rats were more likely to have dermatitis than male rats.

3. Bacteriologic examination was performed in the intergenerationally malnourished and control animals; Staphylococcus aureus was isolated from the skins of animals in both groups, whether or not any lesion was present. In these two groups of animals, experimental inoculation with S. aureus produced dermatitis only in the malnourished animals.

Type
Papers on General Nutrition
Information
British Journal of Nutrition , Volume 41 , Issue 3 , May 1979 , pp. 611 - 618
Copyright
Copyright © The Nutrition Society 1979

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