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Amyotrophic Lateral Sclerosis: Interleukin-6 Levels in Cerebrospinal Fluid

Published online by Cambridge University Press:  18 September 2015

Charles Krieger ,
Thomas L. Perry  and
Hermann J. Ziltener
Charles Krieger*
Affiliation:
Division of Neurology, Department of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
Thomas L. Perry
Affiliation:
Department of Pharmacology and Therapeutics, The University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
Hermann J. Ziltener
Affiliation:
The Biomedical Research Centre, The University of British Columbia, Vancouver, British Columbia, Canada V6T 2B5
*
Division of Neurology, Department of Medicine, University Hospital, U.B.C. site, 2211 Wesbrook Mall, Vancouver, British Columbia, Canada V6T 2B5
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Abstract:

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Recent observations indicate that antibodies to gangliosides are found in many patients with amyotrophic lateral sclerosis (ALS). If antigen-antibody complexes occur in ALS, elevations of cytokine levels might be expected, among them the cytokine interleukin-6 (IL-6). IL-6 is secreted by activated monocytes and other cell types and is an important mediator of the inflammatory response. We have measured cerebrospinal fluid (CSF) IL-6 levels in patients with ALS and compared them with those in psychiatric and neurodegenerative disorders not believed to be due to immune disorders of the central nervous system. We found no significant differences in CSF IL-6 levels between these groups.

Type
Articles
Information
Canadian Journal of Neurological Sciences , Volume 19 , Issue 3 , August 1992 , pp. 357 - 359
Copyright
Copyright © Canadian Neurological Sciences Federation 1992

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