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Cluster Headache: Evidence for a Disorder of Circadian Rhythm and Hypothalamic Function

Published online by Cambridge University Press:  02 December 2014

Tamara Pringsheim
Tamara Pringsheim*
Affiliation:
Department of Neurology, University of Toronto, Toronto, ON Canada
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Abstract

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This article reviews the literature for evidence of a disorder of circadian rhythm and hypothalamic function in cluster headache. Cluster headache exhibits diurnal and seasonal rhythmicity. While cluster headache has traditionally been thought of as a vascular headache disorder, its periodicity suggests involvement of the suprachiasmatic nucleus of the hypothalamus, the biological clock. Normal circadian function and seasonal changes occurring in the suprachiasmatic nucleus and pineal gland are correlated to the clinical features and abnormalities of circadian rhythm seen in cluster headache. Abnormalities in the secretion of melatonin and cortisol in patients with cluster headache, neuroimaging of cluster headache attacks, and the use of melatonin as preventative therapy in cluster headache are discussed in this review. While the majority of studies exploring the relationship between circadian rhythms and cluster headache are not new, we have entered a new diagnostic and therapeutic era in primary headache disorders. The time has come to use the evidence for a disorder of circadian rhythm in cluster headache to further development of chronobiotics in the treatment of this disorder.

Résumé:

RÉSUMÉ:

Cet article revoit la littérature sur les données en faveur d'un désordre du rythme circadien et de la fonction hypothalamique dans la céphalée vasculaire de Horton. Celle-ci a une rythmicité diurne et saisonnière. Bien qu'elle était traditionnellement considérée comme une céphalée vasculaire, sa périodicité suggère l'implication du noyau suprachiasmatique de l'hypothalamus, l'horloge biologique. La fonction circadienne normale et les changements saisonniers survenant dans le noyau suprachiasmatique et la glande pinéale sont corrélés aux manifestations cliniques et aux anomalies du rythme circadien observées dans les céphaléé de Horton. Des anomalies de la sécrétion de la mélatonine et du cortisol chez ces patients, la neuroimagerie des accès de céphalée et l'utilisation de la mélatonine comme traitement préventif des céphalées sont discutées dans cette revue. Bien que la majorité des études sur la relation entre le rythme circadien et la céphalée de Horton ne soient pas récentes, nous sommes entrés dans une nouvelle ère diagnostique et thérapeutique dans le domaine des céphalées primaires. Il est temps d'utiliser les données en faveur d'un désordre du rythme circadien dans la céphalée de Horton pour promouvoir le développement de médicaments chronobiotiques dans le traitement de cette maladie.

Type
Review Article
Information
Canadian Journal of Neurological Sciences , Volume 29 , Issue 1 , February 2002 , pp. 33 - 40
Copyright
Copyright © Canadian Neurological Sciences Federation 2002

References

1. Headache Classification Committee of the International HeadacheSociety. Classification and diagnostic criteria for headache disorders, cranial neuralgias and facial pain. Cephalalgia 1988;8:1–96.Google Scholar
2. Dodick, DW, Rozen, TD, Goadsby, PJ, Silberstein, SD. Clusterheadache. Cephalalgia 2000;20:787–803.CrossRefGoogle Scholar
3. Konopka, RJ, Benzer, S. Clock mutants of Drosophiliamelanogaster. Proc Nat Acad Sci USA 1971;68:2112–2116.Google Scholar
4. Barinaga, M. New clock gene cloned. Science 1995;270:732–733.Google Scholar
5. Gilliam, TC, Kandel, ER, Jessell, TM. Genes and Behavior. In: Kandel, ER, Schwartz, JH, Jessell, TM. Principles of NeuralScience, 4th Edition : McGraw-Hill 2000: 36–61 Google Scholar
6. Myers, MP, Wager-Smith, K, Rothenfluh-Hilfiker, A, Young, MW. Light-induced degradation of TIMELESS and Entrainment of the Drosophila Circadian Clock. Science 1996;271:1736–1740.Google Scholar
7. Moore, RY, Eichler, VB. Loss of a circadian adrenal corticosteronerhythm following suprachiasmatic lesion in the rat. Brain Res 1972;42:201–206.Google Scholar
8. Ibuka, N, Kawamura, H. Loss of circadian sleep-wakefulness cyclein the rat by suprachiasmatic nucleus lesion. Brain Res 1975;96:76–81.CrossRefGoogle Scholar
9. Sawaki, Y, Nihonmatsu, I, Kawamura, H. Transplantation of theneonatal suprachiasmatic nucleus into rats with complete bilateral suprachiasmatic lesion. Neurosci Res 1984:1;67–72.CrossRefGoogle Scholar
10. Moore, RY. The organization of the human circadian timing system. In: Swaab, DF, Hofman, MA, Mirmiran, M, Ravid, R, van Leeuwen, FW. eds. Progress in Brain Research, vol 93. Amsterdam: Elsevier. 1992:101–117.Google Scholar
11. Swaab, DF, Gooren, LJG, Hofman, MA. The human hypothalamus inrelation to gender and sexual orientation. In: Swaab, DF, Hofman, MA, Mirmiran, M, Ravid, R, van Leeuwen, FW eds.. Progress in Brain Research, vol 93. Amsterdam: Elsevier. 1992:205–219.Google Scholar
12. Hofman, MA, Purba, JS, Swaab, DF. Annual variation in thevasopressin neuron population of the human suprachiasmatic nucleus. Neuroscience 1993;53(4):1103–1112.Google Scholar
13. Ibata, Y, Okamura, H, Tanaka, M, et al. Functional morphology of thesuprachiasmatic nucleus. Frontiers Neuroendocrin 1999;20:241–268.Google Scholar
14. Hofman, MA, Swaab, DF. The human hypothalamus: comparativemorphometry and photoperiodic influences. In: Swaab, DF, Hofman, MA, Mirmiran, M, Ravid, R, van Leeuwen, FW, eds. Progress in Brain Research, vol 93. Amsterdam: Elsevier. 1992:133–149.Google Scholar
15. Brzezinski, A. Melatonin in humans. N Eng J Med 1997;336(3):186–195.Google Scholar
16. Kalsbeek, A, Cutrera, RA, Van Heerikhuize, JJ, Vander Vliet, J, Buijs, R. GABA release from SCN terminals is necessary for the light induced inhibition of nocturnal melatonin release in the rat. Neuroscience 1999;91(2):453–461.Google Scholar
17. McNulty, JA, Fox, LM, Spurrier, WA. A circannual cycle inpinealocyte synaptic ribbons in the hibernating and seasonal reproductive 13-lined ground squirrel. Neurosci Lett 1990;119:237–240.Google Scholar
18. Vanecek, J, Illnerova, H. Effect of short and long photoperiods onpineal N-acetyl transferase rhythm and on growth of testes and brown adipose tissue in developing rats. Neuroendocrinology 1985;41:186–191.Google Scholar
19. Sack, RL, Hughes, RJ, Edgar, DM, Lewy, A. Sleep-promoting effectsof melatonin: at what dose, in whom, under what conditions, and by what mechanisms? Sleep 1997;20(10):908–915.CrossRefGoogle Scholar
20. Redman, J, Armstrong, S, Ng, KT. Free-running activity rhythms inthe rat: entrainment by melatonin. Science 1983;219:1089–1091.CrossRefGoogle Scholar
21. Avery, D, Lenz, M, Landis, C. Guidelines for prescribing melatonin. Ann Med 1998;30:122–130.CrossRefGoogle ScholarPubMed
22. Penev, PD, Zee, PC. Melatonin: a clinical perspective. Ann Neurol 1997;42:545–553.Google Scholar
23. Levy, A, Lightman S. Endocrinology. Oxford University Press, 1997.Google Scholar
24. Kudrow, L. The cyclic relationship of natural illumination to clusterperiod frequency. Cephalalgia 1987;7:76–78.Google Scholar
25. Horton, BT. The use of histamine in the treatment of specific typesof headache. JAMA 1941;116:377–383.Google Scholar
26. Ekbom, KA. Ergotamine tartrate orally in Horton’s “histaminiccephalalgia”. Acta Psychiat Scand 1974:46(suppl):106–113.Google Scholar
27. Symonds, CP. A particular variety of headache. Brain 1956;79:217–232.Google Scholar
28. Sahota, RK, Dexter, JD. Sleep and headache syndromes: a clinicalreview. Headache 1990;30:80–84.Google Scholar
29. Manzoni, GC, Terzano, MG, Bono, G, et al. Cluster headache – clinical findings in 180 patients. Cephalalgia 1983;3:21–30.Google Scholar
30. Russell, D. Cluster headache: severity and temporal profiles ofattacks and patient activity prior to and during attacks. Cephalalgia 1981;1:209–216.Google Scholar
31. Dexter, JD, Weitzman, ED. The relationship of nocturnal headachesto sleep stage patterns. Neurology 1970;20:513–518.Google Scholar
32. Kudrow, K, McGinty, DJ, Phillips, ER, Stevenson, M. Sleep apnea incluster headache. Cephalalgia 1984;4:33–38.Google Scholar
33. Nappi, G, Ferrari, E, Polleri, A, Savoldi, F, Vailati, A. Chronobiologicalstudy in cluster headache. Chronobiologia 1981;8:140.Google Scholar
34. Fokin, IV, Kolosova, OA, Levin, YI, Ossipova, VV, Vein, AM. Sleepcharacteristics and psychological peculiarities in cluster headache subjects. In: Oleson, J, Goadsby, PJ, eds. Frontiers in Headache Research Series, vol. 9, Cluster Headache and Related Conditions. 1999;9:196–200.Google Scholar
35. Kudrow, L. Plasma testosterone levels in cluster headache:preliminary results. Headache 1976;16:28–31.Google Scholar
36. Leone, M, Gennaro, B. A review of hormonal findings in clusterheadache. Evidence for hypothalamic involvement. Cephalalgia 1993;13:309–317.CrossRefGoogle Scholar
37. Chazot, G, Claustrat, B, Brun, J, et al. A chronobiological study of melatonin, cortisol, growth hormone, and prolactin secretion incluster headache. Cephalalgia 1984;4:213–220.Google Scholar
38. Waldenlind, E, Gustafsson, SA, Ekbom, K, Wetterberg, L. Circadiansecretion of cortisol and melatonin in cluster headache during active cluster periods and remission. J Neurol Neurosurg Psychiatr 1987;50:207–213.CrossRefGoogle ScholarPubMed
39. Leone, M, Lucini, V, D’Amico, D, et al. Twenty four hour melatoninand cortisol plasma levels in relation to timing of cluster headache. Cephalalgia 1995;15:224–229.Google Scholar
40. Greenspan, FS. Basic and clinical endocrinology. Third Ed. EastNorwalk: Appleton and Lange, 1991.Google Scholar
41. Leone, M, Zappacosta, BM, Valentini, S, Colangelo, AM, Bussone, G. The insulin tolerance test and the ovine corticotrophin-releasing hormone test in episodic cluster headache. Cephalalgia 1991;11:269–274.Google Scholar
42. Leone, M, Maltempo, C, Gritti, A, Bussone, G. The insulin tolerancetest and ovine corticotrophin releasing hormone test in episodic cluster headache II: comparison with low back pain patients. Cephalalgia 1994;14:357–364.CrossRefGoogle Scholar
43. Buijs, RM, Wortel, J, Van Heerikhuize, JJ, et al. Anatomical andfunctional demonstration of a multisynaptic suprachiasmatic nucleus adrenal (cortex) pathway. Eur J Neurosci 1999;11:1535–1544.CrossRefGoogle Scholar
44. Leone, M, D’Amico, D, Moschiano, F, Fraschini, F, Bussone, G. Melatonin versus placebo in the prophylaxis of cluster headache: a double-blind pilot study with parallel groups. Cephalalgia 1996;16:494–496.Google Scholar
45. May, A, Bahra, A, Buchel, C, Frackowiak, RSJ, Goadsby, PJ. Hypothalamic activation in cluster headache attacks. Lancet 1998;352:275–278.Google Scholar
46. May, A, Bahra, A, Buchel, C, Frackowiak, RSJ, Goadsby, PJ. PET and MRA findings in cluster headache and MRA in experimentalpain. Neurology 2000;55:1328–1335.Google Scholar
47. May, A, Ashburner, J, Bushel, C, et al. Correlation between structuraland functional changes in brain in an idiopathic headache syndrome. Nat Med 1999;5(7):732–733.Google Scholar
48. Goadsby, PJ, Edvinsson, L. Humanin vivoevidence fortrigeminovascular activation in cluster headache. Neuropeptide changes and effects of acute attacks therapies. Brain 1994;117:427–434.Google Scholar
49. Golombek, DA, Pevet, P, Cardinali, D. Melatonin effects onbehaviour: possible mediation by the central GABAergic system. Neurosci Biobehav Rev 1996;20:403–412.Google Scholar
50. Geary, GG, Krause, DK, Duckles, SP. Melatonin directly constrictsrat cerebral arteries through modulation of potassium channels. Am J Physiol (Heart Circ Physiol) 1997;42:H1530-H1536.Google Scholar
51. Nagtegaal, JE, Smits, MG, Swart, ACW, Kerkhof, GA, van der Meer, YG. Melatonin-responsive headache in delayed sleep phase syndrome: preliminary observations. Headache 1998;38:303–307.Google Scholar
52. Lewy, AJ. Melatonin as a marker and phase-resetter of circadianrhythms in humans. In: Olcese, J, ed. Melatonin After Four Decades. New York: Kluwer Academic/Plenum Publishers. 2000.Google Scholar
53. Weiller, C, May, A, Limmroth, V. Brain stem activation inspontaneous human migraine attacks. Nat Med 1995;1:658–660.Google Scholar
54. Bahra, A, Matharu, MS, Buchel, C, Fracowiak, RSJ, Goadsby, PJ. Brain stem activation specific to migraine headache. Lancet 2001;357:1016–1017.Google Scholar