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Comparing Cerebellar and Motor Cortical Activity in Reaching and Grasping

Published online by Cambridge University Press:  18 September 2015

M. Smith Allan ,
Dugas Clause ,
Fortier Pierre ,
Kalasha John  and
Picard Nathalie
M. Smith Allan*
Affiliation:
Centre de Recherche en Science Neurologiques, Département de Physiologie, Université de Montréal, Montréal
Dugas Clause*
Affiliation:
Centre de Recherche en Science Neurologiques, Département de Physiologie, Université de Montréal, Montréal
Fortier Pierre*
Affiliation:
Centre de Recherche en Science Neurologiques, Département de Physiologie, Université de Montréal, Montréal
Kalasha John*
Affiliation:
Centre de Recherche en Science Neurologiques, Département de Physiologie, Université de Montréal, Montréal
Picard Nathalie*
Affiliation:
Centre de Recherche en Science Neurologiques, Département de Physiologie, Université de Montréal, Montréal
*
Centre de Recherche en Science Neurologiques, Département de Physiologie, Université de Montréal, C.P.6128 Succ. A, Montréal, Quebec, Canada H3C 3T8
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Abstract:

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The activity of single cells in the cerebellar and motor cortex of awake monkeys was recorded during separate studies of whole-arm reaching movements and during the application of force-pulse perturbations to handheld objects. Two general observations about the contribution of the cerebellum to the control of movement emerge from the data. The first, derived from the study of whole arm reaching, suggests that although both the motor cortex and cerebellum generate a signal related to movement direction, the cerebellar signal is less precise and varies from trial to trial even when the movement kinematics remain unchanged. The second observation, derived from the study of predictable perturbations of a hand-held object, indicates that cerebellar cortical neurons better reflect preparatory motor strategies formed from the anticipation of cutaneous and proprioceptive stimuli acquired by previous experience. In spite of strong relations to grip force and receptive fields stimulated by preparatory grip forces increase, the neurons of the percentral motor cortex showed very little anticipatory activity compared with either the premotor areas or the cerebellum.

Type
Abstract
Information
Canadian Journal of Neurological Sciences , Volume 20 , Issue S3 , May 1993 , pp. S53 - S61
Copyright
Copyright © Canadian Neurological Sciences Federation 1993

References

REFERENCES

1.Hepp-Reymond, M-A.Functional organization of the motor cortex and its participation in voluntary movement. Comp Primate Biol (Neurosciences) 1988; 4: 501–624.Google Scholar
2.Holmes, G.The cerebellum of man. Brain 1939; 62: 1–30.CrossRefGoogle Scholar
3.Asanuma, H, Rosen, I.Topographical organization of cortical efferent zones projecting to distal forelimb muscles in the monkey. Exp Brain Res 1972; 14: 13–27.CrossRefGoogle ScholarPubMed
4.Schmidt, ME, McIntosh, AS.Microstimulation mapping of percentral cortex during trained movements. J Neurophysiol 1990; 64: 1668–1682.CrossRefGoogle Scholar
5.Phillips, CG, Porter, R.Corticospinal Neurones: Their Role in Movement. London, UK: Academic Press 1977.Google Scholar
6.Matsumura, M, Sawaguchi, T, Oishi, T, Ueki, K, Kubota, K.Behavioral deficits induced by local injection of bicuculline and muscimol into the primate motor and premotor cortex. J Neurophysiol 1991; 65: 1542–1553.CrossRefGoogle ScholarPubMed
7.Rispal-Padel, L, Cicirata, F, Pons, C.Cerebellar nuclear topography of simple and synergistic movements in the alert baboon (Papio). Exp Brain Res 1982; 47: 365–380.CrossRefGoogle ScholarPubMed
8.Lamarre, Y, Chapman, CE.Comparative timing of neuronal discharge in cortical and cerebellar structures during a simple arm movement in the monkey. In: Generation and Modulation of Action Patterns. Exp Brain Res Supplementum 15, Berlin: Springer-Verlag 1986; 14–27.Google Scholar
9.Smith, AM, Hepp-Reymond, M-C, Wyss, UR.Relation of activity in precentral cortical neurons to force and rate of force change during isometric contractions of finger muscles. Exp Brain Res 1975; 23: 315–332.CrossRefGoogle ScholarPubMed
10.Smith, AM, Bourbonnais, D.Neuronal activity in cerebellar cortex related to control of prehensile force. J Neurophysiol 1981; 45: 286–303.CrossRefGoogle ScholarPubMed
11.Evarts, EV.Relationship of pyramidal tract activity to force exerted during voluntary movement. J Neurophysiol 1968; 31: 14–27.CrossRefGoogle Scholar
12.Evarts, EV.Activity of pyramidal tract neurons during postural fixation. J Neurophysiol 1969; 32: 375–385.CrossRefGoogle ScholarPubMed
13.Thach, WT.Discharge of cerebellar neurons related to two maintained postures and two prompt movements. I. Nuclear cell output. J Neurophysiol 1970; 33: 527–536.CrossRefGoogle ScholarPubMed
14.Thach, WT.Discharge of cerebellar neurons related to two prompt movements. II. Purkinje cell output and input. J Neurophysiol 1970; 33: 537–547.CrossRefGoogle ScholarPubMed
15.Thach, WT.Correlation of neural discharge with pattern and force of muscular activity, joint position and direction of intended next movement in motor cortex and cerebellum. J Neurophysiol 1976; 41:654–676.CrossRefGoogle Scholar
16.Fortier, PA, Kalaska, JF, Smith, AM.Cerebellar neuronal activity related to whole-arm reaching movements in the monkey. J Neurophysiol 1989; 62: 198–211.CrossRefGoogle ScholarPubMed
17.Kalaska, JF, Cohen, DA, Hyde, ML, Prud’homme, MA.A comparison of movement direction-related versus load direction-related activity in primate motor cortex, using a two-dimensional reaching task. J Neurosci 1989; 9: 2080–2101.CrossRefGoogle ScholarPubMed
18.Mardia, KV.Statistics of Directional Data. New York: Academic Press 1972.Google Scholar
19.Espinoza, E, Smith, AM.Purkinje cell simple spike activity during grasping and lifting objects of different textures and weights. J Neurophysiol 1990; 64: 698–714.CrossRefGoogle ScholarPubMed
20.Dugas, C, Smith, AM.Responses of cerebellar Purkinje cells to slip of a hand-held object. J Neurophysiol 1991; 67: 483–495.CrossRefGoogle Scholar
21.Lamarre, Y, Vachon, P.Motor cortex unit activity associated with triggered movements in the monkeys: effects of dentate and interpositus lesions. Neuroscience 1987; (Suppi 22): S484 (Abstract).Google Scholar
22.Dum, RR, Strick, PL.Premotor areas: nodal points for parallel efferent systems involved in the central control of movement. In: Humphrey, DR, Freund, HJ, eds. Motor Control: Concepts and issues. Chichester, UK: John Wiley & Sons 1991: 383–398.Google Scholar
23.Riehle, A, Requin, J.Monkey primary cortex and premotor cortex: single-cell activity related to prior information about direction and extent of an intended movement. J Neurophysiol 1989; 61: 534–549.CrossRefGoogle ScholarPubMed
24.Mauritz, KH, Wise, SRPremotor cortex of the rhesus monkey: neuronal activity in anticipation of predictable environmental events. Exp Brain Res 1986; 61: 229–244.CrossRefGoogle ScholarPubMed
25.Mintz, AR, Wise, SR.The somatotopic organization of the supplementary motor area: intracortical microstimulation mapping. J Neurosci 1987; 7: 1010–1021CrossRefGoogle Scholar