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Too Much of a Good Thing? Brain Hyper Excitability and Migraine

Published online by Cambridge University Press:  02 December 2014

Werner J. Becker  and
Prin Chitsantikul
Werner J. Becker
Affiliation:
University of Calgary Calgary, Alberta, Canada
Prin Chitsantikul
Affiliation:
University of Calgary Calgary, Alberta, Canada
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Abstract

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Type
Editorial
Information
Canadian Journal of Neurological Sciences , Volume 38 , Issue 2 , March 2011 , pp. 189 - 190
Copyright
Copyright © The Canadian Journal of Neurological 2011

References

1Goadsby, PJ, Charbit, AR, Andreou, AP, Akerman, S, Holland, PR.Neurobiology of migraine. Neuroscience. 2009 Jun 30;161(2): 327–41.Google Scholar
2Bolay, H, Moskowitz, MA.The emerging importance of cortical spreading depression in migraine headache. Rev Neurol (Paris). 2005 Jul;161(6-7):655–7.Google Scholar
3Hadjikhani, N, Sanchez Del Rio, M, Wu, O, et al.Mechanisms of migraine aura revealed by functional MRI in human visual cortex. Proc Natl Acad Sci USA. 2001 Apr 10;98(8):4687–92.Google Scholar
4van den Maagdenberg, AM, Pietrobon, D, Pizzorusso, T, et al.A Cacna1a knockin migraine mouse model with increased susceptibility to cortical spreading depression. Neuron. 2004 Mar 4;41(5):701–10.CrossRefGoogle ScholarPubMed
5Coppola, G, Pierelli, F, Schoenen, J.Is the cerebral cortex hyperexcitable or hyperresponsive in migraine? Cephalalgia. 2007 Dec;27(12):1427–39.Google Scholar
6Lafrenière, RG, Cader, MZ, Poulin, JF, et al.A dominant-negative mutation in the TRESK potassium channel is linked to familial migraine with aura. Nat Med. 2010 Oct;16(10):1157–60.Google Scholar
7Noseda, R, Kainz, V, Jakubowski, M, et al.A neural mechanism for exacerbation of headache by light. Nat Neurosci. 2010 Feb;13 (2):239–45.Google Scholar
8Burstein, R, Yarnitsky, D, Goor-Aryeh, I, Ransil, BJ, Bajwa, ZH.An association between migraine and cutaneous allodynia. Ann Neurol. 2000 May;47(5):614–24.Google Scholar
9Burstein, R, Jakubowski, M, Garcia-Nicas, E, et al.Thalamic sensitization transforms localized pain into widespread allodynia. Ann Neurol. 2010 Jul;68(1):81–91.Google Scholar
10Cooke, L, Eliasziw, M, Becker, WJ.Cutaneous allodynia in transformed migraine patients. Headache. 2007 Apr;47(4):531–9.Google Scholar
11Holland, P, Goadsby, PJ.The hypothalamic orexinergic system: pain and primary headaches. Headache. 2007 Jun;47(6):951–62.Google Scholar
12Bartsch, T, Levy, MJ, Knight, YE, Goadsby, PJ.Inhibition of nociceptive dural input in the trigeminal nucleus caudalis by somatostatin receptor blockade in the posterior hypothalamus. Pain. 2005 Sep;117(1-2):30–9.CrossRefGoogle ScholarPubMed
13Moulton, EA, Burstein, R, Tully, S, Hargreaves, R, Becerra, L, Borsook, D.Interictal dysfunction of a brainstem descending modulatory center in migraine patients. PLoS One. 2008;3(11): e3799.Google Scholar
14Goadsby, PJ.Neurovascular headache and a midbrain vascular malformation: evidence for a role of the brainstem in chronic migraine. Cephalalgia. 2002 Mar;22(2):107–11.Google Scholar
15Lai, KL, Liao, KK, Fuh, JL, Wang, SJ.Subcortical hyperexcitability in migraineurs: a high-frequency oscillation study. Can J Neurol Sci. 2011 Mar;38(2):309–16.CrossRefGoogle ScholarPubMed
16Bolay, H, Reuter, U, Dunn, AK, Huang, Z, Boas, DA, Moskowitz, MA.Intrinsic brain activity triggers trigeminal meningeal afferents in a migraine model. Nat Med. 2002 Feb;8(2):136–42.CrossRefGoogle Scholar
17Sanchez-Del-Rio, M, Reuter, U, Moskowitz, MA.New insights into migraine pathophysiology. Curr Opin Neurol. 2006 Jun;19(3):294–8.Google Scholar