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Hétérogénéité des déficits cognitifs dans la démence de type Alzheimer et prise en charge cognitive de la mémoire: particularités et enjeux méthodologiques

Published online by Cambridge University Press:  31 March 2010

Nathalie Bier ,
Lise Gagnon  and
Johanne Desrosiers
Nathalie Bier*
Affiliation:
Université de Sherbrooke, Sherbrooke, Canada Centre de recherche sur le vieillissement, Institut Universitaire de gériatrie de Sherbrooke
Lise Gagnon
Affiliation:
Université de Sherbrooke, Sherbrooke, Canada Centre de recherche sur le vieillissement, Institut Universitaire de gériatrie de Sherbrooke
Johanne Desrosiers
Affiliation:
Université de Sherbrooke, Sherbrooke, Canada Centre de recherche sur le vieillissement, Institut Universitaire de gériatrie de Sherbrooke
*
Les demandes de tirés à part doivent être adressées à : / Inquiries and requests for offprints should be sent to: Nathalie Bier, Centre de recherche sur le vieillissement, Institut Universitaire de gériatrie de Sherbrooke, 1036 rue Belvédère Sud, Sherbrooke, QC J1H 4C4. (Nathalie.Bier@USherbrooke.ca)
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Abstract

Numerous studies suggest that the clinical presentation of Alzheimer's disease (AD) is varied and that AD is thus a heterogeneous disorder. Evidence of this inter-individual variability has had an important impact on the approaches to the cognitive rehabilitation of AD, particularly in the early stages of the disease. Research has shown that, despite variable cognitive profiles, many preserved capabilities are observed in the first stages of AD and that the disease does not affect all cognitive functions globally. These preserved capabilities make it possible to apply cognitive interventions. However, numerous methodological difficulties are encountered in evaluating the effectiveness of these interventions, many of which are related to the heterogeneity of the deficits. The purpose of this article is to discuss this heterogeneity and its impact on methodological characteristics, especially participant selection and research design.

Abstract

De nombreuses études ont révélé que la démence de type Alzheimer (DTA) se présente sous plusieurs formes et qu'elle est donc une maladie hétérogèse. L'établissement de cette variabilité interindividuelle a eu des répercussions importantes sur la conception de la prise en charge cognitive des personnes atteintes, particulièrement en début de maladie. Il a été démontre que, malgré des profils cognitifs variables, de nombreuses capacités sont préservées en début de maladie et que la DTA n'affecte pas toutes les fonctions cognitives de façon globale. Ces capacités préservées permettent la mise en place d'une prise en charge cognitive. Cependant, l'évaluation de l'efficacité de cette prise en charge présente plusieurs difficultés sur le plan méthodologique, liées entres autres à l'hétérogénéité des déficits. Cet article a pour but de discuter de cette hétérogénéité et de son impact sur des aspects méthodologiques, plus spécifiquement sur la sélection des sujets et le dispositif de recherche.

Keywords

agingAlzheimer's diseasecognitive interventionheterogeneitymethodological considerationsvieillissementmaladie d'Alzheimerintervention cognitivehétérogénéitéaspects méthodologiques
Type
Articles
Information
Canadian Journal on Aging / La Revue canadienne du vieillissement , Volume 24 , Issue 3 , Fall/Automne 2005 , pp. 275 - 284
Copyright
Copyright © Canadian Association on Gerontology 2005

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