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Do quantitative levels of cardiac troponin I implicate on severity of disease in children, adolescences, and young adults with acute myocarditis and myopericarditis?

Published online by Cambridge University Press:  06 February 2023

Sharon Brosilow Open the ORCID record for Sharon Brosilow [Opens in a new window] ,
Wisam Abo Zaid ,
Daniel Maghen ,
Asaad Khoury ,
Doron Aharonson  and
Avraham Lorber
Sharon Brosilow*
Affiliation:
Pediatric Cardiology & Congenital Heart Disease in Adults, The Ruth Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa, Israel Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Wisam Abo Zaid
Affiliation:
Pediatric Cardiology & Congenital Heart Disease in Adults, The Ruth Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa, Israel Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Daniel Maghen
Affiliation:
Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Asaad Khoury
Affiliation:
Pediatric Cardiology & Congenital Heart Disease in Adults, The Ruth Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa, Israel Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
Doron Aharonson
Affiliation:
Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel Cardiac Intensive Care, Cardiology Unit, Rambam Health Care Campus, Haifa, Israel
Avraham Lorber
Affiliation:
Pediatric Cardiology & Congenital Heart Disease in Adults, The Ruth Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa, Israel Ruth and Bruce Rappaport Faculty of Medicine, Technion-Israel Institute of Technology, Haifa, Israel
*
Author for correspondence: Sharon Brosilow, Pediatric Cardiology & Congenital Heart Disease in Adults, The Ruth Rappaport Children’s Hospital, Rambam Health Care Campus, Haifa, Israel. E-mail: sharon.brosilow@gmail.com
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Abstract

Objectives:

When cardiac muscle damage occurs, cardiac troponins are released to blood and their detection is used as a marker in clinical setting. The prognostic value of the quantitative levels of blood troponin I in cases of myocarditis and myopericarditis is unclear. The aim of this study was to analyse whether troponin quantitative blood levels can be correlated with the course of hospitalisation and prognosis.

Methods:

Retrospective data was collected from all consecutive patients aged ≤30 hospitalised with a diagnosis of acute myocarditis or acute myopericarditis in our health Care Campus between the years 2010–2016.

Results:

Ninety-three patients with myocarditis and myopericarditis were identified. Higher peak troponin levels correlated with longer hospitalisation times in the cardiac or paediatric wards (p = 0.03, Pearson correlation: r −0.23), and median troponin level at admission correlated with longer overall hospitalisation (p = 0.026, Pearson correlation: r = 0.23). Patients admitted to ICU, received oral cardiac supportive therapy or that were discharged with cardiac drugs had higher median troponin compared to patients who were not but this was not statistically significant. A small group of patients that needed intravenous cardiac support had significantly lower median peak troponin levels (n = 4, 0.375ng/ml, p = 0.048). Only two patients needed extracorporeal membrane oxygenation support, and one died. The small number of patients precludes statistical analysis.

Conclusion:

Higher troponin levels correlated significantly with longer hospitalisation, lower troponin values correlated with intravenous cardiac support, while other variables related to the severity of disease could not be significantly related to higher troponin levels.

Keywords

Myocarditismyopericarditistroponinprognosis
Type
Original Article
Information
Cardiology in the Young , Volume 33 , Issue 11 , November 2023 , pp. 2315 - 2318
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Copyright
© The Author(s), 2023. Published by Cambridge University Press

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