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COMT Inhibitors: Novel Treatments for Parkinson's Disease

Published online by Cambridge University Press:  07 November 2014

Charles H. Adler
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Abstract

Catechol-O-methyltransferase (COMT) inhibitors are a new class of medication being developed for the treatment of Parkinson's disease (PD). The enzyme COMT metabolizes levodopa and dopamine, both peripherally and centrally. Coadministration of a COMT inhibitor with levodopa creates an increase in peripheral and central levodopa bioavailability, as well as higher central dopamine concentrations. Because these actions improve the duration of response to levodopa, the COMT inhibitors should prove to be useful adjunctive therapies in PD patients.

Type
Feature Articles
Information
CNS Spectrums , Volume 3 , Issue 2: Pathophysiologic and Clinical Progress in Parkinson's Disease , February 1998 , pp. 53 - 56
Copyright
Copyright © Cambridge University Press 1998

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