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Childhood adversity is linked to adult health among African Americans via adolescent weight gain and effects are genetically moderated

Published online by Cambridge University Press:  06 May 2020

Steven R. H. Beach Open the ORCID record for Steven R. H. Beach [Opens in a new window] ,
Mei Ling Ong ,
Man-Kit Lei ,
Eric Klopack ,
Sierra E. Carter ,
Ronald L. Simons ,
Frederick X. Gibbons ,
Justin A. Lavner ,
Robert A. Philibert  and
Kaixiong Ye
Steven R. H. Beach*
Affiliation:
Department of Psychology, University of Georgia, Athens, GA, USA Center for Family Research, University of Georgia, Athens, GA, USA
Mei Ling Ong
Affiliation:
Center for Family Research, University of Georgia, Athens, GA, USA
Man-Kit Lei
Affiliation:
Department of Sociology, University of Georgia, Athens, GA, USA
Eric Klopack
Affiliation:
Department of Sociology, University of Georgia, Athens, GA, USA
Sierra E. Carter
Affiliation:
Department of Psychology, Georgia State University, Atlanta, GA, USA
Ronald L. Simons
Affiliation:
Department of Sociology, University of Georgia, Athens, GA, USA
Frederick X. Gibbons
Affiliation:
Department of Psychological Sciences, University of Connecticut, Storrs, CT, USA
Justin A. Lavner
Affiliation:
Department of Psychology, University of Georgia, Athens, GA, USA Center for Family Research, University of Georgia, Athens, GA, USA
Robert A. Philibert
Affiliation:
Department of Psychiatry, University of Iowa, Iowa City, IA, USA Behavioral Diagnostics, Coralville, IA, USA
Kaixiong Ye
Affiliation:
Department of Genetics and Institute of Bioinformatics, University of Georgia, Athens, GA, USA
*
Author for correspondence: Steven R. H. Beach, Center for Family Research, University of Georgia, 1095 College Station Road, Athens, GA 30602-4527; E-mail: srhbeach@uga.edu.
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Abstract

Identifying the mechanisms linking early experiences, genetic risk factors, and their interaction with later health consequences is central to the development of preventive interventions and identifying potential boundary conditions for their efficacy. In the current investigation of 412 African American adolescents followed across a 20-year period, we examined change in body mass index (BMI) across adolescence as one possible mechanism linking childhood adversity and adult health. We found associations of childhood adversity with objective indicators of young adult health, including a cardiometabolic risk index, a methylomic aging index, and a count of chronic health conditions. Childhood adversities were associated with objective indicators indirectly through their association with gains in BMI across adolescence and early adulthood. We also found evidence of an association of genetic risk with weight gain across adolescence and young adult health, as well as genetic moderation of childhood adversity's effect on gains in BMI, resulting in moderated mediation. These patterns indicated that genetic risk moderated the indirect pathways from childhood adversity to young adult health outcomes and childhood adversity moderated the indirect pathways from genetic risk to young adult health outcomes through effects on weight gain during adolescence and early adulthood.

Keywords

African Americanchildhood adversitygenetic riskhealth disparitiesobesity
Type
Regular Articles
Information
Development and Psychopathology , Volume 33 , Issue 3 , August 2021 , pp. 803 - 820
Copyright
Copyright © Cambridge University Press 2020

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