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Aetiologies and risk factors for neonatal sepsis and pneumonia mortality among Alaskan infants

Published online by Cambridge University Press:  09 May 2005

B. D. GESSNER
Affiliation:
Alaska Division of Public Health, Section of Epidemiology, Anchorage, Alaska, USA
L. CASTRODALE
Affiliation:
Alaska Division of Public Health, Section of Epidemiology, Anchorage, Alaska, USA
M. SORIANO-GABARRO
Affiliation:
Meningitis and Special Pathogens Branch, US Centers for Disease Control and Prevention, Atlanta, GA, USA
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Abstract

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We evaluated all fatal neonatal sepsis and pneumonia cases occurring in Alaska during 1992–2000. Risk factors were evaluated using a database of all births occurring during the study period. Of 32 cases, group B streptococcus (GBS) was isolated from 21% (all <7 days of age), Candida spp. from 19% (all >7 days of age), non-GBS Gram-positive bacteria from 50% (53% <7 days of age), and Gram-negative infections from 38% (58% <7 days of age). Infants born at <37 weeks gestation accounted for 72% of cases and had an increased risk of GBS [rate ratio (RR) 9·1, 95% confidence interval (CI) 2·0–41] and non-GBS (RR 40, 95% CI 16–101) disease. Neonatal sepsis mortality has become an outcome concentrated among pre-term infants. Aetiologies include GBS during the early neonatal period, Candida spp. during the late neonatal period, and other bacteria during both periods.

Type
Research Article
Copyright
2005 Cambridge University Press