Hostname: page-component-78c5997874-xbtfd Total loading time: 0 Render date: 2024-10-31T23:18:49.613Z Has data issue: false hasContentIssue false

Antidepressants and sexual dysfunction: study with vortioxetina

Published online by Cambridge University Press:  23 March 2020

O. Porta Olivares
Affiliation:
Hospital universitario Marqués de Valdecilla, General Psychiatry, Santander, Spain
M. Juncal Ruiz
Affiliation:
Hospital universitario Marqués de Valdecilla, General Psychiatry, Santander, Spain
B. Fernández Abascal Puente
Affiliation:
Hospital universitario Marqués de Valdecilla, General Psychiatry, Santander, Spain
M. Gómez Revuelta
Affiliation:
Hospital Universitario de Álava, General Psychiatry, Vitoria-Gasteiz, Spain
M. Pérez Herrera
Affiliation:
Hospital universitario Marqués de Valdecilla, General Psychiatry, Santander, Spain
L. Garcia Ayala
Affiliation:
Hospital Universitario de Álava, General Psychiatry, Vitoria-Gasteiz, Spain
R. Landera Rodríguez
Affiliation:
Hospital universitario Marqués de Valdecilla, General Psychiatry, Santander, Spain
N.I. Nuñez Morales
Affiliation:
Hospital Universitario de Álava, General Psychiatry, Vitoria-Gasteiz, Spain
G. Pardo de Santayana Jenaro
Affiliation:
Hospital universitario Marqués de Valdecilla, General Psychiatry, Santander, Spain
L. Sánchez Blanco
Affiliation:
Hospital universitario Marqués de Valdecilla, General Psychiatry, Santander, Spain

Abstract

Core share and HTML view are not available for this content. However, as you have access to this content, a full PDF is available via the ‘Save PDF’ action button.
Introduction

Antidepressant treatment, although it is effective to improve the manifestations of major depression, may also induce or exacerbate some symptoms of sexual dysfunction. Symptoms such as decreased libido, anorgasmia, delayed ejaculation, erection difficulty or dyspareunia, affect the quality of life of the subject who suffers and the self-esteem, can lead to lack of adherence to treatment and in accordingly, the relapse of depressive symptoms. Serotonergic antidepressants are frequently associated with the onset of sexual dysfunction in sexually active patients exceeding 70%. Clinicians underestimate the actual incidence of dysfunction as the technical specifications of drugs show lower levels than 25% and spontaneous reports of patients do not exceed 20-40%.

Aims

Vortioxetina is a reuptake inhibitor of serotonin (5-HT) and is also an agonist of the 5-HT1A partial agonist 5-HT1B and an antagonist of 5-HT3, 5-HT1D and 5-HT7. Apparently, this molecule at doses of between 5 and 15 mg is safe and effective and does not cause sexual dysfunction. It is a well-tolerated and safe, with low incidence of sexual dysfunction.

Methods

To evaluate the action we have evaluated sexual dysfunction in patients with major depression before receiving treatment vortioxetina (whether state or not previously treated with other antidepressants) and at 2, 6 and 12 months after starting treatment with the drug. So we’ve used the SALSex scale (Scale for measuring sexual dysfunction secondary to psychotropic drugs).

Results

The results of this study are still being analyzed.

Disclosure of interest

The authors have not supplied their declaration of competing interest.

Type
e-Poster viewing: Cultural psychiatry
Copyright
Copyright © European Psychiatric Association 2017
Submit a response

Comments

No Comments have been published for this article.