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FC07-02 - Increased parahippocampal and lingual gyrification in first-episode schizophrenia

Published online by Cambridge University Press:  16 April 2020

C.C. Schultz ,
K. Koch ,
G. Wagner ,
M. Roebel ,
I. Nenadic ,
C. Gaser ,
C. Schachtzabel ,
J. Reichenbach ,
H. Sauer  and
R.G.M. Schlößer
C.C. Schultz
Affiliation:
University of Jena, Jena, Germany
K. Koch
Affiliation:
University of Jena, Jena, Germany
G. Wagner
Affiliation:
University of Jena, Jena, Germany
M. Roebel
Affiliation:
University of Jena, Jena, Germany
I. Nenadic
Affiliation:
University of Jena, Jena, Germany
C. Gaser
Affiliation:
University of Jena, Jena, Germany
C. Schachtzabel
Affiliation:
University of Jena, Jena, Germany
J. Reichenbach
Affiliation:
University of Jena, Jena, Germany
H. Sauer
Affiliation:
University of Jena, Jena, Germany
R.G.M. Schlößer
Affiliation:
University of Jena, Jena, Germany

Abstract

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Introduction

Surface based MRI methods are a promising approach for the identification of cerebral shape alterations in schizophrenia [1]. In particular, investigating gyrification might offer important evidence for disturbed neurodevelopmental mechanisms in schizophrenia.

Objective

The present study is the first to compare on a vertex - wise basis mean curvature as a sensitive parameter for the identification of local gyrification changes in first episode schizophrenia.

Methods

54 patients with first-episode schizophrenia and 54 healthy control subjects underwent high-resolution T1-weighted MRI scans. Surface extraction and mean curvature calculation was performed using the Freesurfer Software package. Statistical cortical maps were created to estimate gyrification differences between groups.

Results

A significantly increased gyrification was detected in patients relative to controls in a large right parahippocampal-lingual cortex area. A further analysis of cortical thickness of this cluster revealed concurrent significant reduced cortical thickness in patients.

Conclusions

This is the first study to reveal an aberrant gyrification of the medial surface in first episode schizophrenia on basis of a vertex - wise analysis of local gyrification changes of the entire cortex. Both affected areas, the parahippocampal and the lingual cortex, are of high pathophysiological relevance for schizophrenia. Thus, our data provided new in vivo evidence for an early maturational deficit of these cortical areas in schizophrenia [2].

Type
Research Article
Information
European Psychiatry , Volume 26 , Issue S2: Abstracts of the 19th European Congress of Psychiatry , March 2011 , pp. 1847
Copyright
Copyright © European Psychiatric Association 2011

References

Schultz, C.C., et al.Reduced cortical thickness in first episode schizophrenia. Schizophr Res 1162–32010 20420910.1016/j.schres.2009.11.001CrossRefGoogle ScholarPubMed
Schultz, C.C., et al., Increased parahippocampal and lingual gyrification in first-episode schizophrenia. Schizophr Res, in press.Google Scholar
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