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Fiber tracking of white matter integrity connecting the mediodorsal nucleus of the thalamus and the prefrontal cortex in schizophrenia: A diffusion tensor imaging study

Published online by Cambridge University Press:  16 April 2020

Shinsuke Kito ,
Jiuk Jung ,
Tetsuo Kobayashi  and
Yoshihiko Koga
Shinsuke Kito*
Affiliation:
Department of Neuropsychiatry, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo181-8611, Japan
Jiuk Jung
Affiliation:
Department of Electrical Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan
Tetsuo Kobayashi
Affiliation:
Department of Electrical Engineering, Graduate School of Engineering, Kyoto University, Kyoto, Japan
Yoshihiko Koga
Affiliation:
Department of Neuropsychiatry, Kyorin University School of Medicine, 6-20-2 Shinkawa, Mitaka, Tokyo181-8611, Japan
*
*Corresponding author. Tel.: +81 422 47 5511x2885; fax: +81 422 45 4697. E-mail address: kito@kk.iij4u.or.jp (S. Kito).
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Abstract

The goal of this study was to detect abnormalities in white matter integrity connecting the mediodorsal nucleus of the thalamus and the prefrontal cortex using fiber-tracking technique. Diffusion tensor imaging was acquired in 20 patients with schizophrenia and 20 normal comparison subjects. Fiber tracking was performed on the anterior thalamic peduncle, and the tractography was used to determine the cross-sectional area, mean fractional anisotropy, and standard deviation of fractional anisotropy for every step separately in the right and left hemispheres. Compared with normal subjects, patients showed a significant reduction in the cross-sectional area of the left anterior thalamic peduncle. There were no significant differences for the mean fractional anisotropy bilaterally between the two groups, but significant differences for the standard deviation of fractional anisotropy in both hemispheres. Reduction in the cross-sectional area of the left anterior thalamic peduncle suggests the presence of the failure of left-hemisphere lateralization. In schizophrenic patients a significant increase of the standard deviation of fractional anisotropy raise the possibility that the inhomogeneity of white matter integrity, which is densely or sparsely distributed by site. These findings might provide further evidence for disruption of white matter integrity between the thalamus and the prefrontal cortex in schizophrenia.

Keywords

Diffusion tensor imagingTractographyFiber trackingSchizophreniaFractional anisotropyMRI
Type
Original article
Information
European Psychiatry , Volume 24 , Issue 5 , June 2009 , pp. 269 - 274
Copyright
Copyright © Elsevier Masson SAS 2009

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