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Genetic association between −93A/G polymorphism in the Fyn kinase gene and alcohol dependence in Spanish men

Published online by Cambridge University Press:  16 April 2020

Isabel J. Pastor ,
F. Javier Laso ,
Sandra Inés ,
Miguel Marcos  and
Rogelio González-Sarmiento
Isabel J. Pastor
Affiliation:
Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Avda. de Alfonso X el Sabio s/n, 37007Salamanca, Spain Unidad de Alcoholismo, Servicio de Medicina Interna, Hospital Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain
F. Javier Laso
Affiliation:
Unidad de Alcoholismo, Servicio de Medicina Interna, Hospital Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain
Sandra Inés
Affiliation:
Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Avda. de Alfonso X el Sabio s/n, 37007Salamanca, Spain Unidad de Alcoholismo, Servicio de Medicina Interna, Hospital Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain
Miguel Marcos
Affiliation:
Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Avda. de Alfonso X el Sabio s/n, 37007Salamanca, Spain Unidad de Alcoholismo, Servicio de Medicina Interna, Hospital Universitario de Salamanca, Universidad de Salamanca, Salamanca, Spain
Rogelio González-Sarmiento*
Affiliation:
Unidad de Medicina Molecular, Departamento de Medicina, Universidad de Salamanca, Avda. de Alfonso X el Sabio s/n, 37007Salamanca, Spain
*
*Corresponding author. Tel.: +34 923294553; fax: +34 923394593. E-mail address: gonzalez@usal.es (R. González-Sarmiento).
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Abstract

Background

Fyn tyrosine kinase is a member of the Scr family that phosphorylates the NR2A and NR2B subunits of the NMDA receptors reducing the inhibitory effects of ethanol and therefore may regulate the individual sensitivity to ethanol.

Objectives

To investigate whether there is any relationship between the polymorphism at position −93 of the Fyn kinase gene and the susceptibility to develop alcoholism.

Methods

We studied the distribution of genotypes and alleles of the polymorphism −93A/G (137346 T/C) in the 5′ UTR region of the fyn gene in 207 male heavy drinkers (119 with alcohol dependence and 88 with alcohol abuse) and 100 control subjects from Castilla y León (Spain).

Results

The frequency of G allele carriers was higher in alcohol dependents than in alcohol abusers (47.9% vs 30.6%; p = 0.015; OR = 2.077; 95% CI 1.165–3.704).

Conclusion

Our results show that the −93G allele of Fyn kinase gene is associated with higher risk to develop alcohol dependence in Spanish men.

Keywords

Fyn kinaseProtein-tyrosine kinasePolymorphismAlcoholismAlcoholAlcohol abuseAlcohol dependence
Type
Original article
Information
European Psychiatry , Volume 24 , Issue 3 , April 2009 , pp. 191 - 194
Copyright
Copyright © Elsevier Masson SAS 2009

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