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The impact of maternal SARS-COV-2 infection in early stages of newborn neurodevelopment: preliminary results in a multicenter Spanish study

Published online by Cambridge University Press:  01 September 2022

Á. Castro Quintas ,
N. San Martín ,
I. De Las Cuevas ,
E. Eixarch ,
M. Daura-Corral ,
M. Lopez ,
L. De La Fuente Tomas ,
M.P. Garcia-Portilla ,
L. Fañanas  and
R. Ayesa-Arriola
Á. Castro Quintas*
Affiliation:
Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain University of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, Spain
N. San Martín
Affiliation:
University of Barcelona, Department Of Evolutive Biology, Ecology And Ambiental Sciences, Barcelona, Spain
I. De Las Cuevas
Affiliation:
Universitary Hospital Marques de Valdecilla, Neonatology, Santander, Spain
E. Eixarch
Affiliation:
Maternitat Hospital Clinic Barcelona, Bcnatal Fetal Medicine Research Center, Barcelona, Spain
M. Daura-Corral
Affiliation:
University of Barcelona, Department Of Evolutive Biology, Ecology And Ambiental Sciences, Barcelona, Spain
M. Lopez
Affiliation:
Maternitat Hospital Clinic Barcelona, Bcnatal Fetal Medicine Research Center, Barcelona, Spain
L. De La Fuente Tomas
Affiliation:
University of Oviedo, Department Of Psychiatry, Oviedo, Spain
M.P. Garcia-Portilla
Affiliation:
Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain
L. Fañanas
Affiliation:
Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain University of Barcelona, Evolutionary Biology, Ecology And Environmental Sciences, Barcelona, Spain
R. Ayesa-Arriola
Affiliation:
Centre for Biomedical Research Network on Mental Health (CIBERSAM), Instituto De Salut Carlos Iii, Madrid, Spain Valdecilla Biomedical Research Institute, Psychiatry, Santander, Spain
*
*Corresponding author.

Abstract

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Introduction

The consequences for the COVID-19 pandemic in the newborns of affected mothers remains unknown. Previous clinical experiences with other infections during pregnancy lead to considered pregnant women and their offspring especially vulnerable for SARS-COV-2. That is, the underlying physiopathological changes caused by the infection (e.g. storm of cytokines, micro-coagulation in placenta or vertical transmission) could clearly compromise fetal neurodevelopment.

Objectives

To analyze the impact of maternal SARS-COV-2 infection during pregnancy in early neurodevelopment of infants gestated during the COVID-19 pandemic period compared to those gestated immediately prior (2017-2021).

Methods

212 pregnant women (14% infected) were followed throughout their pregnancy and postpartum, including newborn development. SARS-COV-2 infection was serologically confirmed during pregnancy. The Brazelton Neonatal Assessment Scale (NBAS) was administered at 6 weeks old by a trained neonatologist to evaluate neurological, social and behavioral aspects of newborn’s functioning. Differences in NBAS scores between cases and controls were tested by ANOVAs. All the analysis were adjusted for maternal age, sociodemographic status, anxious-depressive symptomatology, infant’s sex and gestational age at birth and NBAS, and for the period of gestation (previous or during COVID-19 pandemic).

Results

NBAS social interactive dimension was significantly decreased in those infants exposed to prenatal SARS-COV-2 (F=4.248, p=.043), particularly when the infection occurred before the week 20 of gestation. Gestation during COVID-19 pandemic did not alter NBAS subscales.

Conclusions

SARS-COV-2 infection during pregnancy seems to be associated with lower NBAS scores on social dimension in 6 weeks old exposed newborns.

Disclosure

No significant relationships.

Keywords

Newborn DevelopmentPregnancy InfectionCOVID19NBAS
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S103
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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