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Predictors of compliance with neuroleptic medication among inpatients with schizophrenia: a discriminant function analysis

Published online by Cambridge University Press:  16 April 2020

G. Donohoe ,
N. Owens ,
C. O’Donnell ,
T. Burke ,
L. Moore ,
A. Tobin  and
E. O’Callaghan
G. Donohoe
Affiliation:
Department of Adult Psychiatry, Cluain Mhuire Service, Hospitaller Order John of God, Dublin, Ireland Department of Psychology, University College Dublin, Dublin, Ireland
N. Owens
Affiliation:
Department of Adult Psychiatry, Cluain Mhuire Service, Hospitaller Order John of God, Dublin, Ireland
C. O’Donnell
Affiliation:
Department of Adult Psychiatry, Cluain Mhuire Service, Hospitaller Order John of God, Dublin, Ireland
T. Burke
Affiliation:
Department of Psychology, University College Dublin, Dublin, Ireland
L. Moore
Affiliation:
Department of Adult Psychiatry, Cluain Mhuire Service, Hospitaller Order John of God, Dublin, Ireland
A. Tobin
Affiliation:
Eli Lilly Pharmaceuticals, (Ireland)
E. O’Callaghan*
Affiliation:
Department of Adult Psychiatry, Cluain Mhuire Service, Hospitaller Order John of God, Dublin, Ireland
*
*Correspondence and reprints: Cluain Mhuire Service, Newtownpark Avenue, Blackrock, Co. Dublin, Ireland. E-mail address: eadbhard@indigo (E. O'Callaghan).
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Summary

Objective. To identify clinically useful predictors of adherence to medication among persons with schizophrenia. Method. We evaluated levels of compliance with neuroleptic medication among 32 consecutive admissions with DSM-III-R schizophrenia from a geographically defined catchment area using a compliance interview. We also assessed symptomatology, insight, neurological status and memory. Results. Less than 25% of consecutive admissions reported being fully compliant. Drug attitudes were the best predictor of regular compliance, symptomatology the best predictor of noncompliance, and memory the best predictor of partial compliance with neuroleptic medication. Conclusions. These data emphasise the complexity of factors that influence whether a person adheres to his medication regimen. Furthermore, they suggest that these factors may vary within the same person over time.

Keywords

adherencecompliancedrug attitudesinsightneurolepticsschizophrenia
Type
Original article
Information
European Psychiatry , Volume 16 , Issue 5 , August 2001 , pp. 293 - 298
Copyright
Copyright © Éditions scientifiques et médicales Elsevier SAS 2001

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References

Adams, S.GHowe, JT.Predicting medication compliance in a psychotic population. J Nerv Ment Dis 1993; 181: 558–60.CrossRefGoogle Scholar
American Psychiatric Association. Structured Clinical Interview for the DSM-III-R. Washington DC: APA; 1992.Google Scholar
Barnes, TR.Rating scale for drug induced akathisia. Br J Psychiatry 1989; 154: 672–6.CrossRefGoogle ScholarPubMed
Buchanan, A.A two year prospective study of treatment compliance in patient with schizophrenia. Psychol M 1992; 22: 787–97.CrossRefGoogle ScholarPubMed
David, A.Insight and psychosis. Br J Psychiatry 1990; 156: 798–808.CrossRefGoogle ScholarPubMed
Dencker, SJLiberman, RP.From compliance to collaboration in the treatment of schizophrenia. Int Clin Psychopharmacol 9Suppl51995 75–8.CrossRefGoogle ScholarPubMed
Endicott, JSpitzer, RLFleiss, JLCohen, J.The Global Assessment Scale: a procedure for measuring overall severity of psychiatric disturbance. Arch Gen Psychiatry 1976; 33: 766–71.CrossRefGoogle ScholarPubMed
Fenton, WSBlyer, CRHeinssen, RK.Determinants of medication compliance in schizophrenia: empirical and clinical findings. Schizophr Bull 1997; 23: 637–51.CrossRefGoogle ScholarPubMed
Fleischhacker, WWMeise, UGunther, VKurz, M.Compliance with antipsychotic drug treatment: influence of side effects. Acta Psychiatr Scand 1994; 89: 11–5.Google Scholar
Folstein, MFolstein, SMcHugh, P.“Mini-Mental State”. A practical method for grading the cognitive state of patients for the clinician. J Psychiatr Res 1975; 12: 189–98.CrossRefGoogle ScholarPubMed
Guy, W.ECDEU. Assessment manual for psychopharmacology. Washington DC: US Dept of Health, Education and Welfare; 1976. 534–7.Google Scholar
Hale, AS.Atypical antipsychotic and compliance in schizophrenia. Nord J Psychiatry 1995; 49(Suppl35): 31–9.CrossRefGoogle Scholar
Hoffman, RPMoore, WEO'Dea, LF.A potential role for pharmacists: medication problems confronted by the schizophrenic outpatient. J Am Pharm Assoc 1974; NS14: 252–65.Google Scholar
Hogan, TPAwad, AGEastwood, R.A self report scale predictive of drug compliance in schizophrenics: reliability and discriminative validity. Psychol M 1983; 13: 177–83.CrossRefGoogle ScholarPubMed
Kay, SRFisbein, AOpler, LA.The Positive And Negative Syndrome Scale (PANSS) for schizophrenia. Schizophr Bull 1987; 13: 261–76.CrossRefGoogle Scholar
Lieberman, JASheitman, BBKinon, BJ.Neurochemical sensitization in the pathophysiology of schizophrenia: deficits and dysfunction in neuronal regulation and plasticity. Neuropsychopharmacology 1997; 17: 205–29.CrossRefGoogle ScholarPubMed
Nelson, HEO'Connell, A.National Adult Reading Test (NART): Test manual 1984. Windsor: NFER; 1984.Google Scholar
SPSS INC. Base Manual for Windows™. Chicago: SPSS Inc; 1996.Google Scholar
Warrington, EK.Recognition Memory Test; manual 1984. Berkshire: NFER-Nelson; 1984.Google Scholar
Weiden, PJShaw, EMann, J.Antipsychotic therapy: patient preferences and compliance. Curr Appr Psychosis 1995; 4: 1–7.Google Scholar
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