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Significant early and long-term improvement of neuropsychiatry symptomatology in HCV-infected patients after viral eradication with DAA

Published online by Cambridge University Press:  01 September 2022

R. Martin-Santos ,
C. Bartrés ,
L. Nacar ,
R. Navinés ,
M. Cavero ,
S. Lens ,
S. Rodriguez-Tajes ,
J.C. Pariante ,
I. Horrillo  and
E. Muñoz-Moreno
...Show all authors
R. Martin-Santos*
Affiliation:
Hospital Clínic,, 1department Of Psychiatry And Psychology, Barcelona, Spain
C. Bartrés
Affiliation:
Hospital Clínic,, UB, IDIBAPS, CIBERSAM, Liver Unit, Barcelona, Spain
L. Nacar
Affiliation:
Hospital Clínic,, UB, IDIBAPS, CIBERSAM, 1department Of Psychiatry And Psychology, Barcelona, Spain
R. Navinés
Affiliation:
Hospital Clínic,, UB, IDIBAPS, CIBERSAM, 1department Of Psychiatry And Psychology, Barcelona, Spain
M. Cavero
Affiliation:
Hospital Clínic,, UB, IDIBAPS, CIBERSAM, 1department Of Psychiatry And Psychology, Barcelona, Spain
S. Lens
Affiliation:
Hospital Clínic,, UB, IDIBAPS, CIBERSAM, Liver Unit, Barcelona, Spain
S. Rodriguez-Tajes
Affiliation:
Hospital Clínic,, UB, IDIBAPS, CIBERSAM, Liver Unit, Barcelona, Spain
J.C. Pariante
Affiliation:
Hospital Clinic, IDIBAPS, Neuroradiology Section, Barcelona, Spain
I. Horrillo
Affiliation:
Universidad del Pais Vasco, Pharmacology, Bilbao, Spain
E. Muñoz-Moreno
Affiliation:
Hospital Clinic, IDIBAPS, Neuroradiology Section, Barcelona, Spain
N. Bargallo
Affiliation:
Hospital Clinic, IDIBAPS, Neuroradiology Section, Barcelona, Spain
L. Capuron
Affiliation:
INRA, Universite Bordeaux, Laboratory Of Nutrition And Integrative Neurobiology, Bordeaux, France
J. Meana
Affiliation:
Universidad del Pais Vasco, Pharmacology, Bilbao, Spain
X. Forns
Affiliation:
Hospital Clínic,, UB, IDIBAPS, CIBERSAM, Liver Unit, Barcelona, Spain
Z. Mariño
Affiliation:
Hospital Clínic,, UB, IDIBAPS, CIBERSAM, Liver Unit, Barcelona, Spain
*
*Corresponding author.

Abstract

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Introduction

Chronic Hepatitis C infection is considered a systemic disease with extrahepatic manifestations, mainly neuropsychiatric symptoms, which is associated with a chronic low-grade inflammatory state. Hepatitis C virus (HCV) eradication is currently achieved in >98% of cases with oral direct-acting antivirals (DAA).

Objectives

To study potential clinical neuropsychiatric changes (mood, cognition, sleep, gastrointestinal, sickness, and motion) in HCV-infected patients after HCV eradication with DAA.

Methods

Design: Cohort study. Subjects: 37 HCV-infected patients, aged<55 years old, with non-advanced liver disease receiving DAA; free of current mental disorder. 24 healthy controls were included at baseline. Assessment: -Baseline (BL) (socio-demographic and clinical variables, MINI-DSM-IV, and Neurotoxicity Scale (NRS), (mood, cognitive, sleep, gastrointestinal, sickness and motor dimensions). Follow-up: End-of-treatment, 12weeks-after and 48weeks-after DAA: NRS. Analysis: Descriptive and bivariate non-parametrical analysis.

Results

NRS total score and dimensions where different between cases and controls (.000) at baseline. NRS total score (.000) and mood (.000), cognition (.000), sleep (.002), gastrointestinal (.017), and sickness (.003), except motor dimension score (.130) showed significant longitudinal improvement.

Conclusions

HCV-infected patients with mild liver disease presented significantly worse scores for neurotoxicity symptomatology in all dimensions compared to healthy individuals. After HCV eradication with DAA, both at short and long follow-up a significant improvement of the NRS total score and each of the dimensions (except motor) were observed. However, they did not reach the values of healthy individuals, suggesting a not complete neuropsychiatric restoration in the period studied. Grant: ICIII-FIS:PI17/02297.(One way to make Europe) (RMS) and Gilead Fellowship-GLD17/00273 (ZM); and the support of SGR17/1798 (RMS)

Disclosure

No significant relationships.

Keywords

moodtreatment responseviral hepatitiscognition
Type
Abstract
Information
European Psychiatry , Volume 65 , Special Issue S1: Abstracts of the 30th European Congress of Psychiatry , June 2022 , pp. S238 - S239
Creative Commons
Creative Common License - CCCreative Common License - BY
This is an Open Access article, distributed under the terms of the Creative Commons Attribution licence (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted re-use, distribution, and reproduction in any medium, provided the original work is properly cited.
Copyright
© The Author(s), 2022. Published by Cambridge University Press on behalf of the European Psychiatric Association
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