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Antimicrobial never events: Objective application of a framework to assess vancomycin appropriateness

Published online by Cambridge University Press:  29 December 2020

Jiajun Liu
Affiliation:
Midwestern University, Downers Grove, Illinois Midwestern University Chicago College of Pharmacy Pharmacometrics Center of Excellence, Downers Grove, Illinois Northwestern Memorial Hospital, Chicago, Illinois
Nicholas J. Mercuro
Affiliation:
Department of pharmacy, Beth Israel Deaconess Medical Center, Boston, Massachusetts
Susan L. Davis
Affiliation:
Henry Ford Hospital, Detroit, Michigan Wayne State University, Detroit, Michigan
Tenzin Palmo
Affiliation:
Midwestern University, Downers Grove, Illinois
Shivek Kashyap
Affiliation:
Midwestern University, Downers Grove, Illinois
Twisha S. Patel
Affiliation:
Michigan Medicine University of Michigan, Ann Arbor, Michigan
Lindsay A. Petty
Affiliation:
Michigan Medicine University of Michigan, Ann Arbor, Michigan
Paul R. Yarnold
Affiliation:
Optimal Data Analysis, Chicago, Illinois University of South Carolina, Columbia, South Carolina
Keith S. Kaye
Affiliation:
Michigan Medicine University of Michigan, Ann Arbor, Michigan
Marc H. Scheetz*
Affiliation:
Midwestern University, Downers Grove, Illinois Midwestern University Chicago College of Pharmacy Pharmacometrics Center of Excellence, Downers Grove, Illinois Northwestern Memorial Hospital, Chicago, Illinois
*
Author for correspondence: Marc H. Scheetz, E-mail: mschee@midwestern.edu

Abstract

To address appropriateness of antibiotic use, we implemented an electronic framework to evaluate antibiotic “never events” (NEs) at 2 medical centers. Patient-level vancomycin administration records were classified as NEs or non-NEs. The objective framework allowed capture of true-positive vancomycin NEs in one-third of patients identified by the electronic strategy.

Type
Concise Communication
Copyright
© The Author(s), 2020. Published by Cambridge University Press on behalf of The Society for Healthcare Epidemiology of America

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References

Scheetz, MH, Crew, PE, Miglis, C, et al. Investigating the extremes of antibiotic use with an epidemiologic framework. Antimicrob Agents Chemother 2016;60:32653269.CrossRefGoogle ScholarPubMed
Yu, KC, Moisan, E, Tartof, SY, et al. Benchmarking inpatient antimicrobial use: a comparison of risk-adjusted observed-to-expected ratios. Clin Infect Dis 2018; 67:16771685.CrossRefGoogle ScholarPubMed
Morris, AM. Antimicrobial stewardship programs: appropriate measures and metrics to study their impact. Curr Treat Options Infect Dis 2014; 6:101112.CrossRefGoogle ScholarPubMed
Suda, KJ, Calip, GS, Zhou, J, et al. Assessment of the appropriateness of antibiotic prescriptions for infection prophylaxis before dental procedures, 2011 to 2015. JAMA Netw Open 2019;2:e193909.CrossRefGoogle ScholarPubMed
Smith, DRM, Dolk, FCK, Pouwels, KB, Christie, M, Robotham, JV, Smieszek, T. Defining the appropriateness and inappropriateness of antibiotic prescribing in primary care. J Antimicrob Chemother 2018;73 suppl 2:ii11ii18.CrossRefGoogle ScholarPubMed
Liu, J, Kaye, KS, Mercuro, NJ, et al. It is time to define antimicrobial never events. Infect Control Hosp Epidemiol 2019;40:206207.CrossRefGoogle ScholarPubMed
Centers for Disease Control and Prevention (CDC). National Healthcare Safety Network (NHSN) antimicrobial use and resistance (AUR) module. Atlanta, GA: CDC; 2020.Google Scholar
Baggs, J, Fridkin, SK, Pollack, LA, Srinivasan, A, Jernigan, JA. Estimating national trends in inpatient antibiotic use among US hospitals from 2006 to 2012. JAMA Intern Med 2016;176:16391648.CrossRefGoogle ScholarPubMed
Tamma, PD, Avdic, E, Li, DX, et al. Association of adverse events with antibiotic use in hospitalized patients. JAMA Intern Med 2017;177:13081315.CrossRefGoogle ScholarPubMed
Branch-Elliman, W, O’Brien, W, Strymish, J, Itani, K, Wyatt, C, Gupta, K. Association of duration and type of surgical prophylaxis with antimicrobial-associated adverse events. JAMA Surg 2019;154:590598.CrossRefGoogle ScholarPubMed
Denny, KJ, Gartside, JG, Alcorn, K, et al. Appropriateness of antibiotic prescribing in the emergency department. J Antimicrob Chemother 2019;74:515520.CrossRefGoogle ScholarPubMed
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