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Comparison of Laboratory-Confirmed Influenza and Noninfluenza Acute Respiratory Illness in Healthcare Personnel during the 2010–2011 Influenza Season

Published online by Cambridge University Press:  10 May 2016

Emily Henkle ,
Stephanie A. Irving ,
Allison L. Naleway ,
Manjusha J. Gaglani ,
Sarah Ball ,
Sarah Spencer ,
Sam Peasah  and
Mark G. Thompson
Emily Henkle*
Affiliation:
Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon
Stephanie A. Irving
Affiliation:
Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon
Allison L. Naleway
Affiliation:
Center for Health Research, Kaiser Permanente Northwest, Portland, Oregon
Manjusha J. Gaglani
Affiliation:
Scott and White Healthcare, Temple, Texas
Sarah Ball
Affiliation:
Abt Associates, Cambridge, Massachusetts
Sarah Spencer
Affiliation:
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia
Sam Peasah
Affiliation:
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia
Mark G. Thompson
Affiliation:
Influenza Division, Centers for Disease Control and Prevention, Atlanta, Georgia
*
Center for Health Research, Kaiser Permanente Northwest, 3800 North Interstate Avenue, Portland, OR 97227 (allison.naleway@kpchr.org)
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Abstract

Objective.

Compare the severity of illnesses associated with influenza and noninfluenza acute respiratory illness (ARI) in healthcare personnel (HCP).

Design.

Prospective observational cohort.

Participants.

HCP at 2 healthcare organizations with direct patient contact were enrolled prior to the 2010–2011 influenza season.

Methods.

HCP who were fewer than 8 days from the start of fever/feverishness/chills and cough were eligible for real-time reverse-transcription polymerase chain reaction influenza virus testing of respiratory specimen. Illness severity was assessed by the sum of self-rated severity (0, absent; 3, severe) of 12 illness symptoms, subjective health (0, best health; 9, worst health), activities of daily living impairment (0, able to perform; 9, unable to perform), missed work, and duration of illness.

Results.

Of 1,701 HCP enrolled, 267 were tested for influenza, and 58 (22%) of these tested positive. Influenza compared with noninfluenza illnesses was associated with higher summed 12-symptom severity score (mean [standard deviation], 17.9 [5.4] vs 14.6 [4.8]; P < .001), worse subjective health (4.5 [1.8] vs 4.0 [1.8]; P < .05), greater impairment of activities of daily living (4.9 [2.5] vs 3.8 [2.5]; P < .01), and more missed work (12.1 [10.5] vs 7.8 [10.5] hours; P < .01). Differences in symptom severity, activities of daily living, and missed work remained significant after adjusting for illness and participant characteristics.

Conclusions.

Influenza had a greater negative impact on HCP than noninfluenza ARIs, indicated by higher symptom severity scores, less ability to perform activities of daily living, and more missed work. These results highlight the importance of efforts to prevent influenza infection in HCP.

Type
Original Article
Information
Infection Control & Hospital Epidemiology , Volume 35 , Issue 5 , May 2014 , pp. 538 - 546
Copyright
Copyright © The Society for Healthcare Epidemiology of America 2014

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