Hostname: page-component-848d4c4894-xm8r8 Total loading time: 0 Render date: 2024-06-14T10:01:59.147Z Has data issue: false hasContentIssue false

Universal screening for Clostridioides difficile at an urban academic medical center

Published online by Cambridge University Press:  22 September 2020

Maggie Collison*
Affiliation:
Section of Infectious Disease, Department of Medicine, University of Chicago, Chicago, Illinois
Cynthia Murillo
Affiliation:
Department of Infection Control and Prevention, University of Chicago, Chicago, Illinois
Rachel Marrs
Affiliation:
Department of Infection Control and Prevention, University of Chicago, Chicago, Illinois
Allison Bartlett
Affiliation:
Section of Infectious Disease, Department of Pediatrics, University of Chicago, Chicago, Illinois
Vera Tesic
Affiliation:
Department of Pathology, University of Chicago, Chicago, Illinois
Kathleen G. Beavis
Affiliation:
Department of Pathology, University of Chicago, Chicago, Illinois
Emily Landon
Affiliation:
Section of Infectious Disease, Department of Medicine, University of Chicago, Chicago, Illinois
Jessica P. Ridgway
Affiliation:
Section of Infectious Disease, Department of Medicine, University of Chicago, Chicago, Illinois
*
Author for correspondence: Maggie Collison, E-mail: Maggie.collison@uchospitals.edu

Abstract

We implemented universal inpatient Clostridioides difficile screening at an 800-bed hospital. Over 3 years, 2,010 of 47,048 screening tests (4.2%) were positive, with significantly higher rates of C. difficile colonization on transplant units than medical-surgical units: 5.4% (152 of 2,801) versus 4.3% (880 of 20,564), respectively (P = .005). Compliance with screening ranged from 79% to 96%.

Type
Concise Communication
Copyright
© 2020 by The Society for Healthcare Epidemiology of America. All rights reserved.

Access options

Get access to the full version of this content by using one of the access options below. (Log in options will check for institutional or personal access. Content may require purchase if you do not have access.)

References

Centers for Disease Control and Prevention. Antibiotic Resistance Threats in the United States, 2019. Atlanta, GA: CDC; 2019.Google Scholar
Guh, AY, Mu, Y, Winston, LG, et al. Trends in US burden of Clostridioides difficile infection and outcomes. N Engl J Med 2020;382:13201330.CrossRefGoogle Scholar
Caroff, DA, Yokoe, DS, Klompas, M. Evolving insights into the epidemiology and control of Clostridium difficile in hospitals. Clin Infect Dis 2017;65:12321238.CrossRefGoogle ScholarPubMed
Riggs, MM, Sethi, AK, Zabarsky, TF, Eckstein, EC, Jump, RL, Donskey, CJ. Asymptomatic carriers are a potential source for transmission of epidemic and nonepidemic Clostridium difficile strains among long-term care facility residents. Clin Infect Dis 2007;45:992998.CrossRefGoogle ScholarPubMed
Linsenmeyer, K, O’Brien, W, Brecher, SM, et al. Clostridium difficile screening for colonization during an outbreak setting. Clin Infect Dis 2018;67:19121914.Google ScholarPubMed
Barker, AK, Alagoz, O, Safdar, N. Interventions to reduce the incidence of hospital-onset Clostridium difficile infection: an agent-based modeling approach to evaluate clinical effectiveness in adult acute care hospitals. Clin Infect Dis 2018;66:11921203.CrossRefGoogle ScholarPubMed
McDonald, LC, Gerding, DN, Johnson, S, et al. Clinical practice guidelines for Clostridium difficile infection in adults and children: 2017 update by the Infectious Diseases Society of America (IDSA) and Society for Healthcare Epidemiology of America (SHEA). Clin Infect Dis 2018;66(7):e1e48.CrossRefGoogle Scholar
Multidrug-resistant organism and Clostridioides difficile infection (MDRO/CDI) module. Centers for Disease Control and Prevention website. https://www.cdc.gov/nhsn/PDFs/pscManual/12pscMDRO_CDADcurrent.pdf. Published January 2020. Accessed August 25, 2020.Google Scholar
Longtin, Y, Paquet-Bolduc, B, Gilca, R, et al. Effect of detecting and isolating Clostridium difficile carriers at hospital admission on the incidence of C difficile infections: a quasi-experimental controlled study. JAMA Intern Med 2016;176:796804.CrossRefGoogle Scholar
Paquet-Bolduc, B, Gervai, P, Roussy et al. Detection and isolation of Clostridium difficile asymptomatic carriers during Clostridium difficile infection outbreaks: an exploratory study. Clin Infect Dis 2018;67:17811783.Google ScholarPubMed