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Decreased Lumbar Cerebrospinal Fluid Levels of Monoamine Metabolites in Vascular Dementia

Published online by Cambridge University Press:  07 January 2005

Anders Wallin ,
Kaj Blennow ,
Åke Edman  and
Jan-Erik Månsson
Anders Wallin
Affiliation:
Göteborg University, Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Mölndal Hospital, Mölndal, Sweden
Kaj Blennow
Affiliation:
Göteborg University, Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Mölndal Hospital, Mölndal, Sweden
Åke Edman
Affiliation:
Göteborg University, Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Mölndal Hospital, Mölndal, Sweden Department of Psychiatry, Varberg Hospital, Varberg, Sweden.
Jan-Erik Månsson
Affiliation:
Göteborg University, Institute of Clinical Neuroscience, Department of Psychiatry and Neurochemistry, Mölndal Hospital, Mölndal, Sweden
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Abstract

The levels of the monoamine metabolites 5-hydroxy-indoleacetic acid (5-HIAA), homovanillic acid (HVA), and 4-hydroxy-3-methoxyphenylglycol (HMPG) were determined in lumbar cerebrospinal fluid (CSF) of 56 patients with vascular dementia (VAD) and 57 healthy controls. Despite CSF sampling under standardized conditions, the variability in values was wide among both patients and controls. This suggests that yet unknown factors affect the lumbar CSF concentrations of monoamine metabolites. The VAD group showed significantly lower mean concentrations of 5-HIAA (p < .001) and HVA (p < .001) than the control group. These low concentrations appear to be no disease-specific phenomenon, but may be attributable to subcortical white-matter changes or a decreased production of monoamines, which are dependent on oxygen for their synthesis.

Type
Studies on Dementia
Information
International Psychogeriatrics , Volume 8 , Issue 3 , September 1996 , pp. 425 - 436
Copyright
© 1996 International Psychogeriatric Association

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