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Comparison between two preventive treatments for hyperketonaemia carried out pre-partum: effects on non-esterified fatty acids, β-hydroxybutyrate and some biochemical parameters during peripartum and early lactation

Published online by Cambridge University Press:  17 February 2021

Enrico Fiore ,
Laura Perillo ,
Matteo Gianesella ,
Claudia Giannetto ,
Elisabetta Giudice ,
Giuseppe Piccione  and
Massimo Morgante
Enrico Fiore
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 16, 35020Legnaro (PD), Italy
Laura Perillo
Affiliation:
Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
Matteo Gianesella
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 16, 35020Legnaro (PD), Italy
Claudia Giannetto
Affiliation:
Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
Elisabetta Giudice
Affiliation:
Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
Giuseppe Piccione*
Affiliation:
Department of Veterinary Science, University of Messina, Polo Universitario dell'Annunziata, 98168, Messina, Italy
Massimo Morgante
Affiliation:
Department of Animal Medicine, Productions and Health (MAPS), University of Padua, Viale dell'Università, 16, 35020Legnaro (PD), Italy
*
Author for correspondence: Giuseppe Piccione, Email: gpiccione@unime.it
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Abstract

The objective of this study was to compare the effect of two different preventive protocols, on serum β-hydroxybutyrate (BHB) concentration and liver health indices pre-partum and during early-lactation in high-yielding Holstein dairy cows. One hundred cows were randomly divided into three groups: control group (CTRL, n = 20, without preventive treatment), second group (SUPP, n = 40 animals treated with a compound based on acetyl-methionine, inositol, cyanocobalamin, l-alanine, l-arginine, l-threonine, l-glutamic acid supplementation and α-lipoic acid) and third group (MON, n = 40 animals treated with monensin). Blood samples were collected from all cows at on 3 occasions pre-partum and 3 occasions post-partum. Body condition (BCS) score was evaluated and glucose, non-esterified fatty acids (NEFA), BHB, triglycerides, total cholesterol, alanine aminotransferase (ALT), aspartate aminotransferase (AST), γ-glutamyltransferase (GGT), total bilirubin, total proteins, globulins, albumin and urea concentrations were assessed. Two-way repeated measures analysis of variance was applied. Statistically significant differences among the three experimental groups were found in the values of all studied parameters (P < 0.05). Our results confirm the established beneficial effect of MON treatment in decreasing BHB levels and increasing glucose availability after calving. Serum biochemical analysis revealed the expected post-partum alterations attributable to adaptations that influenced the metabolism and liver function in CTRL, whereas these alterations were reduced or absent in SUPP and MON. Results from the present study suggest that both preventive protocols, but in particular SUPP, could positively affect selected indicators of energy metabolism reducing the risk of hyperketonaemia and increase of liver function in Holstein dairy cows, both pre- and post-partum.

Keywords

Cowhyperketonaemialactationliversupplementation
Type
Research Article
Information
Journal of Dairy Research , Volume 88 , Issue 1 , February 2021 , pp. 38 - 44
Copyright
Copyright © The Author(s), 2021. Published by Cambridge University Press on behalf of Hannah Dairy Research Foundation

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