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MCP-1 and MIP-2 levels during Echinococcus granulosus infections in mice

Published online by Cambridge University Press:  07 February 2017

Y. Theodorides ,
S. Frydas ,
T. Rallis ,
K. Adamama-Moraitou ,
R. Papazahariadou ,
C. Batzios  and
P. Conti
Y. Theodorides
Affiliation:
Laboratory of Parasitology, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece
S. Frydas*
Affiliation:
Laboratory of Parasitology, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece
T. Rallis
Affiliation:
Department of Clinical Studies, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece
K. Adamama-Moraitou
Affiliation:
Department of Clinical Studies, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece
R. Papazahariadou
Affiliation:
Laboratory of Parasitology, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece
C. Batzios
Affiliation:
Laboratory of Economics of Animal Production, Faculty of Veterinary Medicine, Aristotle University of Thessaloniki, 54006 Thessaloniki, Greece
P. Conti
Affiliation:
Immunology Division, School of Medicine, University of Chieti, Italy
*
*Author for correspondence Fax: +30 31 999947 E-mail: trallis@vet.auth.gr
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Abstract

Ten BALB/c mice were infected with the cestode Echinococcus granulosus. After the infection, serum was collected at different periods of time and monocyte chemotactic protein-1 (MCP-1) and macrophage inflammatory protein-2 (MIP-2) were determined. The level of MCP-1 increased from 290±12 pg ml-1 (mean±SD) at day 20 post infection (p.i.), to a maximum of 820±23 pg ml-1 on day 60 p.i., then decreased to 460±12.6 pg ml-1 on day 130 p.i. A second peak was observed at day 150 p.i. In addition, MIP-2 was detectable in serum as late as day 100 p.i. The highest level (100±11 pg ml-1) was observed on day 130 p.i., and decreased thereafter. Serum from noninfected animals (controls) contained no detectable levels of either MCP-1 or MIP-2. However, MCP-1 and MIP-2 appear to be implicated in E. granulosus infections, but their exact role during the disease is under determination.

Type
Research Article
Information
Journal of Helminthology , Volume 75 , Issue 2 , June 2001 , pp. 205 - 208
Copyright
Copyright © Cambridge University Press 2001

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