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Nematospiroides dubius: stimulation of acquired immunity in inbred strains of mice

Published online by Cambridge University Press:  05 June 2009

Jerzy M. Behnke  and
D. Wakelin
Jerzy M. Behnke
Affiliation:
The Wellcome Laboratories for Experimental ParasitologyUniversity of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
D. Wakelin
Affiliation:
The Wellcome Laboratories for Experimental ParasitologyUniversity of Glasgow, Bearsden Road, Bearsden, Glasgow, G61 1QH
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Abstract

The development of immunity to Nematospiroides dubius was studied in three strains of inbred mice (BALB/c, C3H and NIH). Although a primary infection in NIH mice persisted for two months without evidence of a reduction in worm numbers, female mice of this strain readily developed resistance to reinfection. The degree of resistance was enhanced when an immunizing infection of 600 larvae was administered as 6 separate doses of 100 larvae given between days 0 and 11, and the worms removed by anthelmintic treatment given on days 15, 21, 28 and 35. Immunity in mice immunized in this way was manifest both as a reduction in worm recoveries on days 9–14 after challenge and also as an expulsion of established worms from the intestine. BALB/c mice were initially less resistant, but expelled most of the worms which became established; C3H mice showed no evidence of expulsion. The finding that inbred NIH and BALB/c mice acquire resistance to N. dubius offers possibilities for the systematic analysis of lymphoid cell activity in initiating and expressing immunity to this parasite.

Type
Research Article
Information
Journal of Helminthology , Volume 51 , Issue 3 , September 1977 , pp. 167 - 175
Copyright
Copyright © Cambridge University Press 1977

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