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Otogenic brain complications: a systematic review and meta-analysis

Published online by Cambridge University Press:  05 March 2024

Eleni Gkrinia Open the ORCID record for Eleni Gkrinia [Opens in a new window] ,
Alexandros G Brotis ,
Kyriaki Vallianou ,
Anna Maria Ntziovara  and
Jiannis Hajiioannou Open the ORCID record for Jiannis Hajiioannou [Opens in a new window]
Eleni Gkrinia*
Affiliation:
ENT Department, University Hospital of Larissa, Larissa, Greece
Alexandros G Brotis
Affiliation:
Department of Neurosurgery, University Hospital of Larissa, Larissa, Greece
Kyriaki Vallianou
Affiliation:
ENT Department, University Hospital of Larissa, Larissa, Greece
Anna Maria Ntziovara
Affiliation:
ENT Department, University Hospital of Larissa, Larissa, Greece
Jiannis Hajiioannou
Affiliation:
ENT Department, University Hospital of Larissa, Larissa, Greece
*
Corresponding author: Eleni Gkrinia; Email: gkrinia.eleni@gmail.com
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Abstract

Objective

This study aimed to form astute deductions regarding the presentation, treatment and mortality of otogenic brain complications.

Methods

A systematic literature search of four medical databases (PubMed, Embase, Web of Science and Scopus) was conducted. Studies associated with otogenic brain complications were considered eligible. Fixed- and random-effects model meta-analysis was developed to assess the proportion estimate for each outcome individually.

Results

Twenty-eight studies, with 1650 patients in total, were included. In 66 per cent of patients there was a known history of chronic otitis media. The most common symptoms were purulent otorrhoea (84 per cent), headache (65 per cent) and otalgia (45 per cent). A brain abscess was observed in 49 per cent of patients, followed by meningitis (34 per cent) and sinus thrombosis (22 per cent). A combination of surgical and conservative therapy was chosen in 84.3 per cent of cases and the mortality rate approached 11.1 per cent.

Conclusion

Otogenic brain complications are a possibly life-threatening condition. Prompt imaging examination may set the final diagnosis and lead to an effective treatment.

Keywords

Otitis mediaotitis media with effusionmastoiditischolesteatomacommunicable diseases
Type
Main Article
Information
The Journal of Laryngology & Otology , First View , pp. 1 - 10
Copyright
Copyright © The Author(s), 2024. Published by Cambridge University Press on behalf of J.L.O. (1984) LIMITED

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Footnotes

Eleni Gkrinia takes responsibility for the integrity of the content of the paper

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