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Confrontation naming does not add incremental diagnostic utility in MCI and Alzheimer's disease

Published online by Cambridge University Press:  01 July 2004

JULIE A. TESTA ,
ROBERT J. IVNIK ,
BRADLEY BOEVE ,
RONALD C. PETERSEN ,
V. SHANE PANKRATZ ,
DAVID KNOPMAN ,
ERIC TANGALOS  and
GLENN E. SMITH
JULIE A. TESTA
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55901
ROBERT J. IVNIK
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55901 Mayo Alzheimer's Disease Research Center, Rochester, Minnesota 55901
BRADLEY BOEVE
Affiliation:
Mayo Alzheimer's Disease Research Center, Rochester, Minnesota 55901 Department of Neurology, Mayo Clinic, Rochester, Minnesota 55901
RONALD C. PETERSEN
Affiliation:
Mayo Alzheimer's Disease Research Center, Rochester, Minnesota 55901 Department of Neurology, Mayo Clinic, Rochester, Minnesota 55901
V. SHANE PANKRATZ
Affiliation:
Division of Biostatistics, Mayo Clinic, Rochester, Minnesota 55901
DAVID KNOPMAN
Affiliation:
Mayo Alzheimer's Disease Research Center, Rochester, Minnesota 55901 Department of Neurology, Mayo Clinic, Rochester, Minnesota 55901
ERIC TANGALOS
Affiliation:
Mayo Alzheimer's Disease Research Center, Rochester, Minnesota 55901 Division of Community Internal Medicine, Mayo Clinic, Rochester, Minnesota 55901
GLENN E. SMITH
Affiliation:
Department of Psychiatry and Psychology, Mayo Clinic, Rochester, Minnesota 55901 Mayo Alzheimer's Disease Research Center, Rochester, Minnesota 55901
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Abstract

As the incidence of dementia increases, there is a growing need to determine the diagnostic utility of specific neuropsychological tests in the early diagnosis of Alzheimer's disease (AD). In this study, the relative utility of Boston Naming Test (BNT) in the diagnosis of AD was examined and compared to the diagnostic utility of other neuropsychological measures commonly used in the evaluation of AD. Individuals with AD (n = 306), Mild Cognitive Impairment (MCI; n = 67), and cognitively normal subjects (n = 409) with at least 2 annual evaluations were included. Logistic regression analysis suggested that initial BNT impairment is associated with increased risk of subsequent AD diagnosis. However, this risk is significantly less than that imparted by measures of delayed recall impairments. A multivariate Cox proportional hazards regression analysis suggested that BNT impairment imparted no additional risk for subsequent AD diagnosis after delayed recall impairments were included in the model. Although BNT impairment occurred in all severity groups, it was ubiquitous only in moderate to severe dementia. Collectively these results suggest that although BNT impairments become more common as AD progresses, they are neither necessary for the diagnosis of AD nor particularly useful in identifying early AD. (JINS, 2004, 10, 504–512.)

Keywords

Boston Naming TestAlzheimer's diseaseMild Cognitive Impairment
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 10 , Issue 4 , July 2004 , pp. 504 - 512
Copyright
2004 The International Neuropsychological Society

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