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Emotion Recognition Correlates With Social-Neuropsychiatric Dysfunction in Huntington’s Disease

Published online by Cambridge University Press:  28 December 2017

Clare L. Kempnich Open the ORCID record for Clare L. Kempnich [Opens in a new window] ,
Sophie C Andrews ,
Fiona Fisher ,
Dana Wong ,
Nellie Georgiou-Karistianis  and
Julie C. Stout
Clare L. Kempnich
Affiliation:
Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Faculty of Nursing, Medicine, and Health Sciences, Monash University, Clayton Campus, VIC, Australia
Sophie C Andrews
Affiliation:
Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Faculty of Nursing, Medicine, and Health Sciences, Monash University, Clayton Campus, VIC, Australia Statewide Progressive Neurological Disease Service, Calvary Health Care Bethlehem, Caulfield South, VIC, Australia
Fiona Fisher
Affiliation:
Statewide Progressive Neurological Disease Service, Calvary Health Care Bethlehem, Caulfield South, VIC, Australia
Dana Wong
Affiliation:
Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Faculty of Nursing, Medicine, and Health Sciences, Monash University, Clayton Campus, VIC, Australia
Nellie Georgiou-Karistianis
Affiliation:
Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Faculty of Nursing, Medicine, and Health Sciences, Monash University, Clayton Campus, VIC, Australia
Julie C. Stout*
Affiliation:
Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Faculty of Nursing, Medicine, and Health Sciences, Monash University, Clayton Campus, VIC, Australia
*
Correspondence and reprint requests to: Julie C. Stout, Monash Institute of Cognitive and Clinical Neurosciences, School of Psychological Sciences, Faculty of Nursing, Medicine, and Health Sciences, Monash University, Clayton, Victoria 3800, Australia. E-mail: Julie.Stout@monash.edu
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Abstract

Objectives: People with Huntington’s disease (HD) experience poor social quality of life, relationship breakdown, and social withdrawal, which are mediated to some extent by socially debilitating neuropsychiatric symptoms, such as apathy and disinhibition. Social cognitive symptoms, such as impaired emotion recognition, also occur in HD, however, the extent of their association with these socially debilitating neuropsychiatric symptoms is unknown. Our study examined the relationship between emotion recognition and symptom ratings of apathy and disinhibition in HD. Methods: Thirty-two people with premanifest or symptomatic-HD completed Part 1 of The Awareness of Social Inference Test (TASIT), which is a facial emotion recognition task. In addition, we obtained severity ratings for apathy and disinhibition on the Frontal Systems Behavior Scale (FrSBe) from a close family member. Our analyses used motor symptom severity as a proxy for disease progression. Results: Emotion recognition performance was significantly associated with family-ratings of apathy, above and beyond their shared association with disease severity. We found a similar pattern for disinhibition ratings, which fell short of statistical significance. As expected, worse emotion recognition performance was correlated with higher severity in FrSBe symptom ratings. Conclusions: Our findings suggest that emotion recognition abilities relate to key socially debilitating neuropsychiatric symptoms in HD. Our results help to understand the functional significance of emotion recognition impairments in HD, and may have implications for the development of remediation programs aimed at improving patients’ social quality of life. (JINS, 2018, 24, 417–423)

Keywords

Neurodegenerative diseasesHuntington diseaseSocial perceptionApathySocial behaviorEmotions
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 24 , Issue 5 , May 2018 , pp. 417 - 423
Copyright
Copyright © The International Neuropsychological Society 2017 

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