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Hippocampal Atrophy Relates to Fluid Intelligence Decline in the Elderly

Published online by Cambridge University Press:  24 November 2010

Aaron Reuben ,
Adam M. Brickman ,
Jordan Muraskin ,
Jason Steffener  and
Yaakov Stern
Aaron Reuben
Affiliation:
Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, New York
Adam M. Brickman
Affiliation:
Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, New York
Jordan Muraskin
Affiliation:
Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, New York
Jason Steffener
Affiliation:
Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, New York
Yaakov Stern*
Affiliation:
Cognitive Neuroscience Division of the Taub Institute, Columbia University College of Physicians and Surgeons, New York, New York
*
Correspondence and reprint requests to: Yaakov Stern, 630 W 168th Street, P&S Box 16, New York, NY 10032. E-mail: ys11@columbia.edu
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Abstract

Measures of brain and hippocampal volume in 40 healthy young (aged 18–30 years) and 36 healthy elderly (aged 60–83 years) subjects were compared with composite cognitive function scores in three conceptual domains: memory ability, processing speed, and general fluid intelligence. Through a series of general linear models testing the relationship between these brain measures and cognitive performance scores, a significant positive relationship between hippocampal volume and fluid intelligence ability was found in elderly subjects but not in young. No relationship between the other cognitive domains and brain or hippocampal volume was found. The findings suggest a role of hippocampal atrophy in the decline in fluid intelligence in the elderly. (JINS, 2011, 17, 000–000)

Keywords

AgingHippocampusBrain atrophyCognitive declineFluid intelligenceMemory
Type
Research Articles
Information
Journal of the International Neuropsychological Society , Volume 17 , Issue 1 , January 2011 , pp. 56 - 61
Copyright
Copyright © The International Neuropsychological Society 2010

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Footnotes

The present study was supported by NIA R01 AG26158.

References

Buckmaster, A.C., Eichenbaum, H., Amaral, G.D., Suzuki, A.W., Rapp, R.P. (2004). Entorhinal cortex lesions disrupt the relational organization of memory in monkeys. The Journal of Neuroscience, 24(44), 9811–9825.CrossRefGoogle ScholarPubMed
Buschke, H., Fuld, P.A. (1974). Evaluating storage, retention, and retrieval in disordered memory and learning. Neurology, 24, 1019–1025.CrossRefGoogle ScholarPubMed
Chetelat, G., Baron, J.C. (2003). Early diagnosis of Alzheimer’s disease: Contribution of structural neuroimaging. Neuroimage, 18, 525–541.CrossRefGoogle ScholarPubMed
De Leon, M., George, A.E., Golomb, J., Tarshish, C., Convit, A., Kluger, A., Wisniewski, H.M. (1997). Frequency of hippocampal formation atrophy in normal aging and Alzheimer’s disease. Neurobiology of Aging, 18(1), 1–11.CrossRefGoogle ScholarPubMed
Firbank, M.J., Barber, R., Burton, E., O’Brien, J.T. (2008). Validation of a fully automated hippocampal segmentation method on patients with dementia. Human Brain Mapping, 29, 1442–1449.CrossRefGoogle ScholarPubMed
Fotenos, A.F., Snyder, A.Z., Girton, L.E., Morris, J.C., Buckner, R.L. (2005). Normative estimates of cross-sectional and longitudinal brain volume decline in aging and AD. Neurology, 64(6), 1032–1039.CrossRefGoogle ScholarPubMed
Frodl, T., Schaub, A., Banac, S., Charypar, M., Jager, M., Kummler, P., Meisenzahl, E. (2006). Reduced hippocampal volume correlates with executive dysfunctioning in major depression. Journal of Psychiatry Neuroscience, 31(5), 316–325.Google ScholarPubMed
Gary, J., Chabris, C., Braver, T. (2003). Neural mechanisms of general fluid intelligence. Nature Neuroscience, 6, 316–322.CrossRefGoogle Scholar
Goel, V., Makale, M., Grafman, J. (2004). The hippocampal system mediates logical reasoning about familiar spatial environments. Journal of Cognitive Neuroscience, 16(4), 654–664.CrossRefGoogle ScholarPubMed
Golomb, J., de Leon, M., Kluger, A., Ajax, E., Tarshish, C., Ferris, S. (1993). Hippocampal atrophy in normal aging. Archives of Neurology, 50(9), 967–973.CrossRefGoogle ScholarPubMed
Gong, Q., Sluming, V., Mayes, A., Keller, S., Barrick, T., Cezayirli, E., Roberts, N. (2005). Voxel-based morphometry and stereology provide convergent evidence of the importance of medial prefrontal cortex for fluid intelligence in healthy adults. Neuroimage, 25, 1175–1186.CrossRefGoogle ScholarPubMed
Kane, M.J., Engle, R.W. (2002). The role of prefrontal cortex in working-memory capacity, executive attention, and general fluid intelligence: An individual-differences perspective. Psychonomic Bulletin & Review, 9(4), 637–671.CrossRefGoogle ScholarPubMed
Lucas, J.A., Icnick, R.J., Smith, G.E., Bohac, D.L., Tangalos, E.G., Kokmen, E., Graff-Radford, N.R., Petersen, R.C. (1998). Normative data for the Mattis Dementia Rating Scale. Journal of Clinical and Experimental Neuropsychology, 20, 536–547.CrossRefGoogle ScholarPubMed
Mattis, S. (1988). Dementia Rating Scale: Professional Manual. Odessa, FL: Psychological Assessment Resources.Google Scholar
Pfefferbaum, A., Mathalon, D.H., Sullivan, E.V., Rawles, J.M., Zipursky, R.B., Lim, K.O. (1994). A quantitative magnetic resonance imaging study of changes in brain morphology from infancy to late adulthood. Archives of Neurology, 6, 874–887.CrossRefGoogle Scholar
Preston, A.R., Shrager, Y., Dudukovic, N.M., Gabrieli, J.D.E. (2004). Hippocampal contribution to the novel use of relational information in declarative memory. Hippocampus, 14(2), 148–152.CrossRefGoogle Scholar
Rapp, P. (2004). Who’s the fairest of them all? Role of the human hippocampus in the relational organization of memory. Hippocampus, 14(2), 141–142.CrossRefGoogle ScholarPubMed
Raven, J. (1962). Advanced progressive matrices, set II. London, UK: H.K. Lewis, 1–14.Google Scholar
Raz, N., Lindenberger, U., Ghisletta, P., Rodrigue, K.M., Kennedy, K.M., Acker, J.D. (2007). Neuroanatomical correlates of fluid intelligence in healthy adults and persons with vascular risk factors. Cerebral Cortex, 18(3), 718–726.CrossRefGoogle ScholarPubMed
Raz, N., Lindenberger, U., Rodrigue, K.M., Kennedy, K.M., Head, D., Williamson, A., Acker, J.D. (2005). Regional brain changes in aging healthy adults: General trends, individual differences and modifiers. Cerebral Cortex, 15(11), 1676–1689.CrossRefGoogle ScholarPubMed
Raz, N., Rodrigue, K. (2006). Differential aging of the brain: patterns, cognitive correlates and modifiers. Neuroscience and Behavioral Reviews, 30(6), 730–748.CrossRefGoogle ScholarPubMed
Schretlen, D., Pearlson, G.D., Anthony, J.C., Aylward, E.H., Augustine, A.M., Davis, A., Barta, P. (2000). Elucidating the contributions of processing speed, executive ability, and frontal lobe volume to normal age-related differences in fluid intelligence. Journal of the International Neuropsychological Society, 6, 25–61.CrossRefGoogle ScholarPubMed
Siedlecki, K.L., Stern, Y., Reuben, A., Sacco, R.L., Elkind, M.S.V., Wright, C.B. (2009). Construct validity of cognitive reserve in a multi-ethnic cohort: The Northern Manhattan Study. Journal of the International Neuropsychological Society, 15, 558–569.CrossRefGoogle Scholar
Sowell, E.R., Peterson, B.S., Thompson, P.M., Welcome, S.E., Henkenius, A.L., Toga, A.W. (2003). Mapping cortical change across the human life span. Nature Neuroscience, 6, 309–315.CrossRefGoogle ScholarPubMed
Thompson, P.M., Cannon, T.D., Narr, K.L., van Erp, T., Poutanen, V.P., Huttunen, M., Toga, A.W. (2001). Genetic influences on brain structure. Nature Neuroscience, 4, 1253–1258.CrossRefGoogle ScholarPubMed
Van Petten, C. (2004). Relationship between hippocampal volume and memory ability in healthy individuals across the lifespan: Review and meta-analysis. Neuropsychologia, 42, 1394–1413.CrossRefGoogle ScholarPubMed
Van Petten, C., Plante, E., Davidson, P.S.R., Bajuscak, L., Glisky, E.L. (2004). Memory and executive function in older adults: relationships with temporal and prefrontal gray matter volumes and white matter hyperintensities. Neuropsychologia, 42(10), 1313–1335.CrossRefGoogle ScholarPubMed
Wechsler, D. (1981). Wechsler Adult Intelligence Scale – Revised. New York: The Psychological Corporation.Google Scholar
Wechsler, D. (1997). Wechsler Adult Intelligence Scale – third edition. San Antonio, TX: The Psychological Corporation.Google Scholar
Yuan, K., Steedle, J., Shavelson, R., Alonzo, A., Oppezo, M. (2006). Working memory, fluid intelligence, and science learning. Educational Research Review, 1, 83–98.CrossRefGoogle Scholar