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Neuropsychological and sensory gating deficits related to remote alcohol abuse history in schizophrenia

Published online by Cambridge University Press:  23 January 2006

ROBERT J. THOMA ,
FAITH M. HANLON ,
GREGORY A. MILLER ,
MINGXIONG HUANG ,
MICHAEL P. WEISEND ,
FRANCISCO P. SANCHEZ ,
V. ANN WALDORF ,
AARON JONES ,
ASHLEY SMITH  and
MICHAEL J. FORMOSO
...Show all authors
ROBERT J. THOMA
Affiliation:
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico Mental Illness and Neuroscience Discovery (MIND) Institute, Albuquerque, New Mexico Department of Psychology, University of New Mexico, Albuquerque, New Mexico
FAITH M. HANLON
Affiliation:
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico Mental Illness and Neuroscience Discovery (MIND) Institute, Albuquerque, New Mexico Department of Psychology, University of New Mexico, Albuquerque, New Mexico
GREGORY A. MILLER
Affiliation:
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico Departments of Psychology and Psychiatry and Beckman Institute Biomedical Imaging Center, University of Illinois at Urbana-Champaign, Urbana, Illinois
MINGXIONG HUANG
Affiliation:
Department of Radiology, University of California at San Diego, San Diego, California
MICHAEL P. WEISEND
Affiliation:
Mental Illness and Neuroscience Discovery (MIND) Institute, Albuquerque, New Mexico Department of Psychology, University of New Mexico, Albuquerque, New Mexico Department of Radiology, University of New Mexico, Albuquerque, New Mexico
FRANCISCO P. SANCHEZ
Affiliation:
Psychology Service, New Mexico VA Health Care System, Albuquerque, New Mexico
V. ANN WALDORF
Affiliation:
Psychology Service, New Mexico VA Health Care System, Albuquerque, New Mexico
AARON JONES
Affiliation:
Department of Psychology, University of New Mexico, Albuquerque, New Mexico Psychiatry Research Program, New Mexico VA Health Care System, Albuquerque, New Mexico
ASHLEY SMITH
Affiliation:
Department of Psychology, University of New Mexico, Albuquerque, New Mexico Psychiatry Research Program, New Mexico VA Health Care System, Albuquerque, New Mexico
MICHAEL J. FORMOSO
Affiliation:
Department of Psychology, University of New Mexico, Albuquerque, New Mexico Psychiatry Research Program, New Mexico VA Health Care System, Albuquerque, New Mexico
JOSE M. CAÑIVE
Affiliation:
Department of Psychiatry, University of New Mexico School of Medicine, Albuquerque, New Mexico Psychiatry Research Program, New Mexico VA Health Care System, Albuquerque, New Mexico
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Abstract

Recent evidence suggests that changes in brain structure associated with alcohol abuse are compounded in individuals dually diagnosed with alcohol abuse and schizophrenia. To investigate the separate, and possibly interacting, effects of these diagnoses, an event-related brain potential (ERP) measure of auditory information processing (P50 sensory gating paradigm) and neuropsychological measures were administered to healthy control participants with either (1a) no history of alcohol abuse/dependence, or (1b) a remote history of alcohol abuse/dependence, and patients with schizophrenia with either (2a) no history of alcohol abuse/dependence, or (2b) a remote history of alcohol abuse/dependence. Schizophrenia was associated with impaired P50 sensory gating and poorer performance across neuropsychological scores compared to measurements in healthy control participants. Those with a positive alcohol history had impaired gating ratios in contrast to those with a negative alcohol history. There were additive effects of schizophrenia diagnosis and alcohol history for P50 sensory gating and for neuropsychological scores: attention, working memory, and behavioral inhibition. For executive attention and general memory there was an interaction, suggesting that the combination of schizophrenia and history of alcohol abuse results in greater impairment than that predicted by the presence of either diagnosis alone. (JINS, 2006, 12, 34–44.)

Keywords

P50 sensory gatingNeuropsychological assessmentAlcohol abuseAlcohol dependenceEEGEvent-related brain potentials
Type
Research Article
Information
Journal of the International Neuropsychological Society , Volume 12 , Issue 1 , January 2006 , pp. 34 - 44
Copyright
© 2006 The International Neuropsychological Society

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