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Modulated nitric oxide delivery in three-dimensional biomaterials for vascular functionality

Published online by Cambridge University Press:  19 June 2017

Zuyong Wang Open the ORCID record for Zuyong Wang [Opens in a new window] ,
Feng Wen ,
Rongkai Zhang  and
Qinyuan Zhang
Zuyong Wang
Affiliation:
College of Materials Science and Engineering, Hunan University, Changsha 410082, People's Republic of China
Feng Wen*
Affiliation:
School of Chemical and Biomedical Engineering, Nanyang Technological University, Singapore 637459, Singapore
Rongkai Zhang
Affiliation:
Orthopedics Department, The Fifth Affiliated hospital of Sun Yat-sen University, Sun Yat-sen University, Zhuhai 519000, People's Republic of China
Qinyuan Zhang*
Affiliation:
Singapore Institute of Manufacturing Technology, Singapore 138634, Singapore
*
Address all correspondence to Feng Wen, Qinyuan Zhang at wenfeng@ntu.edu.sg, zqinyuan@gmail.com
Address all correspondence to Feng Wen, Qinyuan Zhang at wenfeng@ntu.edu.sg, zqinyuan@gmail.com
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Abstract

Nitric oxide (NO) acts a pivotal role in regulating various physiological processes of vasodilation, platelet aggregation, and vascular smooth muscle cell mitogenesis and proliferation. This makes NO a promising candidate for the treatment of cardiovascular problems like hypertension and vascular stenosis. However, the high reactivity of NO poses an issue for effective NO delivery. To overcome this limitation, recent developments on three-dimensional (3D) materials have been explored with either physical or chemical incorporation of NO releasing donors, to provide spatiotemporal control over NO-signaling pathways in blood vessels. Here, we offer an overview on the current efforts, and propose future perspectives for precise regulation on NO delivery in advanced 3D materials toward proper vascular functionality.

Type
Biomaterials for 3D Cell Biology Prospective Articles
Information
MRS Communications , Volume 7 , Issue 3 , September 2017 , pp. 348 - 360
Copyright
Copyright © Materials Research Society 2017 

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Footnotes

†

These authors contributed equally to this work.

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