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Paper as a scaffold for cell cultures: Teaching an old material new tricks

Published online by Cambridge University Press:  24 January 2018

Xinchen Wu ,
Sanika Suvarnapathaki ,
Kierra Walsh  and
Gulden Camci-Unal
Xinchen Wu
Affiliation:
Biomedical Engineering and Biotechnology Program, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USA
Sanika Suvarnapathaki
Affiliation:
Biomedical Engineering and Biotechnology Program, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USA
Kierra Walsh
Affiliation:
Department of Biological Sciences, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USA
Gulden Camci-Unal*
Affiliation:
Department of Chemical Engineering, University of Massachusetts Lowell, One University Avenue, Lowell, MA 01854, USA
*
Address all correspondence to Gulden Camci-Unal at Gulden_CamciUnal@uml.edu
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Abstract

Paper-based cell culture platforms have emerged as a promising approach for a myriad of biomedical applications, such as tissue engineering, disease models, cancer research, biotechnology, high-throughput testing, biosensing, and diagnostics. Paper enables the generation of highly flexible, biocompatible, inexpensive, porous, and three-dimensional (3D) constructs and devices. These systems have been used to culture mammalian cells, bacteria, algae, and fungi. Studies have shown that paper is an exceptional material for applications in life sciences, materials sciences, engineering, and medicine. Paper has been employed for creating biomimetic cell culture environments by folding or stacking it into the desired 3D shapes and structures. This review discusses the use of paper-based platforms for cellular applications and provides a diverse range of examples.

Type
Prospective Articles
Information
MRS Communications , Volume 8 , Issue 1 , March 2018 , pp. 1 - 14
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Copyright
Copyright © Materials Research Society 2018 

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