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Piezoelectric bioMEMS cantilever for measurement of muscle contraction and for actuation of mechanosensitive cells

Published online by Cambridge University Press:  27 September 2019

Elizabeth A. Coln ,
Alisha Colon ,
Christopher J. Long ,
Narasimhan Narasimhan Sriram ,
Mandy Esch ,
Jean-Matthieu Prot ,
Daniel H. Elbrecht ,
Ying Wang ,
Max Jackson  and
Michael L. Shuler
...Show all authors
Elizabeth A. Coln
Affiliation:
Hybrid Systems Laboratory, University of Central Florida, NanoScience Technology Center, 12424 Research Parkway, Suite 400, Orlando, FL32826, USA Department of Electrical & Computer Engineering, University of Central Florida, 4328 Scorpius St., Orlando, FL32816, USA
Alisha Colon
Affiliation:
Hybrid Systems Laboratory, University of Central Florida, NanoScience Technology Center, 12424 Research Parkway, Suite 400, Orlando, FL32826, USA
Christopher J. Long
Affiliation:
Hesperos, Inc., 3259 Progress Drive #158, Orlando, FL32826, USA
Narasimhan Narasimhan Sriram
Affiliation:
Hesperos, Inc., 3259 Progress Drive #158, Orlando, FL32826, USA
Mandy Esch
Affiliation:
Department of Biomedical Engineering, Cornell University, Weill Hall, Ithaca, NY14853, USA
Jean-Matthieu Prot
Affiliation:
Department of Biomedical Engineering, Cornell University, Weill Hall, Ithaca, NY14853, USA
Daniel H. Elbrecht
Affiliation:
Hybrid Systems Laboratory, University of Central Florida, NanoScience Technology Center, 12424 Research Parkway, Suite 400, Orlando, FL32826, USA
Ying Wang
Affiliation:
Department of Biomedical Engineering, Cornell University, Weill Hall, Ithaca, NY14853, USA
Max Jackson
Affiliation:
Hesperos, Inc., 3259 Progress Drive #158, Orlando, FL32826, USA
Michael L. Shuler
Affiliation:
Hesperos, Inc., 3259 Progress Drive #158, Orlando, FL32826, USA Department of Biomedical Engineering, Cornell University, Weill Hall, Ithaca, NY14853, USA
James J. Hickman*
Affiliation:
Hybrid Systems Laboratory, University of Central Florida, NanoScience Technology Center, 12424 Research Parkway, Suite 400, Orlando, FL32826, USA Department of Electrical & Computer Engineering, University of Central Florida, 4328 Scorpius St., Orlando, FL32816, USA Hesperos, Inc., 3259 Progress Drive #158, Orlando, FL32826, USA
*
Address all correspondence to James J. Hickman at jhickman@ucf.edu
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Abstract

A piezoelectric biomedical microelectromechanical system (bioMEMS) cantilever device was designed and fabricated to act as either a sensing element for muscle tissue contraction or as an actuator to apply mechanical force to cells. The sensing ability of the piezoelectric cantilevers was shown by monitoring the electrical signal generated from the piezoelectric aluminum nitride in response to the contraction of iPSC-derived cardiomyocytes cultured on the piezoelectric cantilevers. Actuation was demonstrated by applying electrical pulses to the piezoelectric cantilever and observing bending via an optical detection method. This piezoelectric cantilever device was designed to be incorporated into body-on-a-chip systems.

Type
Research Letters
Information
MRS Communications , Volume 9 , Issue 4 , December 2019 , pp. 1186 - 1192
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Copyright
Copyright © Materials Research Society 2019

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