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Computational Design, Freeform Fabrication and Testing of Nylon-6 Tissue Engineering Scaffolds

Published online by Cambridge University Press:  11 February 2011

Suman Das ,
Scott J. Hollister ,
Colleen Flanagan ,
Adebisi Adewunmi ,
Karlin Bark ,
Cindy Chen ,
Krishnan Ramaswamy ,
Daniel Rose  and
Erwin Widjaja
Suman Das
Affiliation:
Mechanical Engineering Department, University of Michigan, 2350 Hayward St., Ann Arbor, MI 48109–2125
Scott J. Hollister
Affiliation:
Biomedical Engineering Department, University of Michigan, 2350 Hayward St., Ann Arbor, MI 48109–2125
Colleen Flanagan
Affiliation:
Biomedical Engineering Department, University of Michigan, 2350 Hayward St., Ann Arbor, MI 48109–2125
Adebisi Adewunmi
Affiliation:
Mechanical Engineering Department, University of Michigan, 2350 Hayward St., Ann Arbor, MI 48109–2125
Karlin Bark
Affiliation:
Mechanical Engineering Department, University of Michigan, 2350 Hayward St., Ann Arbor, MI 48109–2125
Cindy Chen
Affiliation:
Mechanical Engineering Department, University of Michigan, 2350 Hayward St., Ann Arbor, MI 48109–2125
Krishnan Ramaswamy
Affiliation:
Mechanical Engineering Department, University of Michigan, 2350 Hayward St., Ann Arbor, MI 48109–2125
Daniel Rose
Affiliation:
Mechanical Engineering Department, University of Michigan, 2350 Hayward St., Ann Arbor, MI 48109–2125
Erwin Widjaja
Affiliation:
Mechanical Engineering Department, University of Michigan, 2350 Hayward St., Ann Arbor, MI 48109–2125
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Abstract

Advanced and novel fabrication methods are needed to build complex three-dimensional scaffolds that incorporate multiple functionally graded biomaterials with a porous internal architecture that will enable the simultaneous growth of multiple tissues, tissue interfaces and blood vessels. The aim of this research is to develop, demonstrate and characterize techniques for fabricating such scaffolds by combining solid freeform fabrication and computational design methods. When fully developed, such techniques are expected to enable the fabrication of tissue engineering scaffolds endowed with functionally graded material composition and porosity exhibiting sharp or smooth gradients. As a first step towards realizing this goal, scaffolds with periodic cellular and biomimetic architectures were designed and fabricated using selective laser sintering in Nylon-6, a biocompatible polymer. Results of bio-compatibility and in vivo implantation studies conducted on these scaffolds are reported.

Type
Research Article
Information
MRS Online Proceedings Library (OPL) , Volume 758: Symposium LL – Rapid Prototyping Technologies , 2002 , LL5.7
Copyright
Copyright © Materials Research Society 2003

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References

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