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The influence of a chronic subclinical infection of Trichostrongylus colubriformis on gastrointestinal motility and digesta flow in sheep

Published online by Cambridge University Press:  06 April 2009

P. C. Gregory ,
G. Wenham ,
D. Poppi ,
R. L. Coop ,
J. C. MacRae  and
S. J. Miller
P. C. Gregory*
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
G. Wenham
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
D. Poppi
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
R. L. Coop
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
J. C. MacRae
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
S. J. Miller
Affiliation:
Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB
*
*Department of Physiology, Rowett Research Institute, Bucksburn, Aberdeen AB2 9SB.
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Extract

The influence of a chronic subclinicael infection of Trichostrongylus colubriformis, 2500 larvae/day for 12 weeks, on gastrointestinal motility and digesta flow was studied in 12 sheep supplied ad libitum with food and water. Motility was recorded by X-radiography and electromyography from chronically implanted electrodes;abomasal volume and outflow were estimated by dilution of CrEDTA; small intestinal transit time was estimated by passage of Phenol Red. The findings were compared with measurements made prior to infection at restricted food intake and reported separately. The first effects of infection were seen after 3–4 weeks. No animal developed diarrhoea, but food intake was progressively reduced. Small intestinal transit time, abomasal volume and half-time of marker dilution increased while abomasal outflow decreased during infection. These changes occurred both in absolute terms and when compared with values predicted from the observed level of food intake. As the animals became resistant to the parasites abomasal volume and digesta flow returned towards control values (weeks 10–12). The migrating myoelectric complex (MMC) was disrupted in only one sheep, and only transiently. In all sheep the frequency of the MMC was increased during infection and there was a progressive inhibition of abomasal, duodenal and jejunal motility. X-radiography showed there was prolonged pooling of digesta in the proximal small intestine which was cleared only at the phase of regular spiking activity. Two sheep given an anthelmintic drench recovered normal motility and clearance of digesta. It is concluded that subclinical infection of sheep with T. colubriformis alters the normal pattern of gastrointestinal motility in the absence of any diarrhoea, and causes inhibition of abomasal and proximal small intestinal motility and digesta flow. The increased frequency of MMCs helps to maintain digesta flow through the proximal small intestine.

Type
Research Article
Information
Parasitology , Volume 91 , Issue 2 , October 1985 , pp. 381 - 396
Copyright
Copyright © Cambridge University Press 1985

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References

REFERENCES

Andrews, J. S. (1939). Experimental trichostrongylosis in sheep and goats. Journal of agricultural Research 58, 761–70.Google Scholar
Bell, F. R. & Watson, D. J. (1976). The influence of gastric distension and the duodenal infusate on the pattern of stomach (abomasal) emptying in the preruminant calf. Journal of Physiology 259, 445–56.CrossRefGoogle ScholarPubMed
Bueno, L., Dakkak, A. & Fioramonti, J. (1982). Gastro-duodenal motor and transit disturbances associated to Haemonchus contortus infection in sheep. Parasitology 84, 367–74.CrossRefGoogle ScholarPubMed
Bueno, L., Dorchies, P. & Ruckebusch, Y. (1975). Analyse électromyographique des perturbations motrices liées aux strongyloses gastro-intestinales chez les ovins. Comptes rendus des seances de la Société de Biologie 169, 1627–32.Google Scholar
Bueno, L. & Fioramonti, J. (1979). Rhythms of abomaso-intestinal motility. In Digestive Physiology and Metabolism in Ruminants (ed. Ruckebusch, Y. and Thivend, P.), pp. 53–80. London: MTP Press.Google Scholar
Castro, G. A., Badial-Aceves, F., Smith, J. W., Dudrick, S. J. & Weisbrodt, N. W. (1976). Altered small bowel propulsion associated with parasitism. Gastroenterology 71, 620–5.CrossRefGoogle ScholarPubMed
Coombe, J. B. & Kay, R. N. B. (1965). Passage of digesta through the intestines of the sheep. Retention times in the small and large intestines. British Journal of Nutrition 19, 325–38.CrossRefGoogle ScholarPubMed
Gibson, T. E., Parfitt, J. W. & Everett, G. (1970). The effect of the anthelmintie treatment of the development of resistance to Trichostrongylus colubriformis in sheep. Research in Veterinary Science 11, 138–45.CrossRefGoogle Scholar
Gregory, P. C., Rayner, D. V. & Wenham, G. (1984). Initiation of migrating myoelectric complex in sheep by duodenal acidification and hyperosmolarity: role of vagus nerves. Journal of Physiology 355, 509–21.CrossRefGoogle ScholarPubMed
Gregory, P. C., Miller, S. J. & Brewer, A. C. (1985). The relationship between food intake and abomasal emptying and small intestinal transit time in sheep. British Journal of Nutrition 53, 373–80.CrossRefGoogle Scholar
Gregory, P. C. & Wenham, G. (1984). Sub-clinical infection with Trichostrongylus colubriformis inhibits abomaso-duodenal transit of digesta in lambs. Gut 25, A 1321–2.Google Scholar
Grovum, W. L. (1981). Factors affecting the voluntary intake of food by sheep. 3. The effect of intravenous infusions of gastrin, cholecystokinin and secretin on motility of the reticulo-rumen and intake. British Journal of Nutrition 45, 183–201.CrossRefGoogle ScholarPubMed
Horak, I. G., Clark, R. & Gray, R. S. (1968). The pathological physiology of helminth infestations. III. Trichostrongylus colubriformis. Onderstepoort Journal of Veterinary Science 35, 195–223.Google Scholar
Houpt, K. A. (1982). Gastrointestinal factors in hunger and satiety. Neuroscience and Behavioural Reviews 6, 145–64.CrossRefGoogle ScholarPubMed
Hubert, J., kerboetjf, D. & Gruner, L. (1979). Study of gastro-intestinal strongylosis in a sheep flock on permanent pasture. 1. Sheep parasitism in 1977. Annales de Recherches véterinaires 10, 503–18.Google Scholar
McLeay, L. M. & Bell, F. R. (1980). Effect of cholecystokinin, secretin, glucagon and insulin on gastric emptying and acid secretion in the calf. American Journal of Veterinary Research 41, 1590–4.Google Scholar
MacRae, J. C., Smith, J. S., Sharman, G. A. M., Corrigall, W. & Coop, R. L. (1982). Energy metabolism of lambs infected with Trichostrongylus colubriformis. In Energy Metabolism of Farm Animals (ed. Ekern, A. and Sundstel, F.). EAAP Publication No. 29, pp. 112–115.Google Scholar
Roseby, F. B. (1973). Effects of Trichostrongylus colubriformis (Nematoda) on the nutrition and metabolism of sheep. 1. Feed intake, digestion and utilization. Australian Journal of Agricultural Research 24, 947–53.CrossRefGoogle Scholar
Roseby, F. B. (1977). Effects of Trichostrongylus colubriformis (Nematoda) in the nutrition and metabolism of sheep. III. Digestas flow and fermentation. Australian Journal of Agricultural Research 28, 155–64.CrossRefGoogle Scholar
Schanbacher, L. M., Nations, J. K., Weisbrodt, N. W. & Castro, G. A. (1978). Intestinal myoelectric activity in parasitized dogs. American Journal of Physiology 234, R188–R195.Google ScholarPubMed
Sykes, A. R. & Coop, R. L. (1976). Intake and utilization of food by growing lambs with parasitic damage to the small intestine caused by daily dosing with Trichostrongylus colubriformis larvae. Journal of Agricultural Science 86, 507–15.CrossRefGoogle Scholar
Symons, L. E. A. (1966). Digestion and absorption of maltose in rats infected by the nematode Nippostrongylus brasiliensis. Experimental Parasitology 18, 12–24.CrossRefGoogle ScholarPubMed
Symons, L. E. A. (1978). Cholecystokinin and anorexia in sheep with intestinal nematode infection. Proceedings of the Nutrition Society Australia 3, 85.Google Scholar
Weisbrodt, N. W. & Castro, G. A. (1977). Intestinal myoelectric activity of the dog during hookworm infection. Federation Proceedings 36, 595.Google Scholar
Wenham, G. & Wyburn, R. S. (1980). A radiological investigation of the effects of cannulation on intestinal motility and digesta flow in sheep. Journal of Agricultural Science 95, 539–46.CrossRefGoogle Scholar