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The endogenous—neurotic distinction as a predictor of response to antidepressant drugs

Published online by Cambridge University Press:  09 July 2009

Allen Raskin  and
Thomas H. Crook
Allen Raskin*
Affiliation:
Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Maryland
Thomas H. Crook
Affiliation:
Psychopharmacology Research Branch, National Institute of Mental Health, Rockville, Maryland
*
*Correspondence and reprint requests should be addressed to Allen Raskin, Ph.D., Psychopharmacology Research Branch, National Institute of Mental Health, 5600 Fishers Lane, Room 9–101, Rockville, Maryland 20852, U.S.A.
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Synopsis

An inverse factor analysis of 880 depressed inpatients on 33 endogenous–neurotic variables yielded four patient types. Type 3 resembled the endogenous depressions and Type 2 the neurotic depressions. Type 3 patients responded well to both imipramine and chlorpromazine and did poorly on a placebo. Type 2 patients showed the greatest overall improvement at three weeks irrespective of treatment received, including a placebo.

Type
Research Article
Information
Psychological Medicine , Volume 6 , Issue 1 , February 1976 , pp. 59 - 70
Copyright
Copyright © Cambridge University Press 1976

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