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Variable clinical response to choline in tardive dyskinesia

Published online by Cambridge University Press:  09 July 2009

Henry A. Nasrallah ,
Frederick J. Dunner ,
Robert E. Smith ,
Mona McCalley-Whitters  and
Arnold D. Sherman
Henry A. Nasrallah*
Affiliation:
From the Veterans Administration Medical Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
Frederick J. Dunner
Affiliation:
From the Veterans Administration Medical Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
Robert E. Smith
Affiliation:
From the Veterans Administration Medical Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
Mona McCalley-Whitters
Affiliation:
From the Veterans Administration Medical Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
Arnold D. Sherman
Affiliation:
From the Veterans Administration Medical Center, Department of Psychiatry, University of Iowa College of Medicine, Iowa City, Iowa, USA
*
1Address for correspondence: Dr Henry A. Nasrallah, Psychiatry Service (116A), Veterans Administration Medical Center, Iowa City, Iowa 52240, USA.
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Synopsis

Tardive dyskinesia is widely believed to be a state of relative hyperdopaminergic and hypocholinergic imbalance in the striatum of patients chronically treated with neuroleptics. However, not all patients with tardive dyskinesia respond to cholinergic drugs, which theoretically should restore the balance and improve the symptoms. We report a controlled, double-blind, crossover study of choline chloride in 11 patients with persistent tardive dyskinesia. Seven patients showed partial or minimal improvement, while two did not change and two deteriorated. The results are discussed in the light of other similar findings in the literature, and the implications for pharmacological subtypes of tardive dyskinesia using cholinergic probes are explored.

Type
Brief Communication
Information
Psychological Medicine , Volume 14 , Issue 3 , August 1984 , pp. 697 - 700
Copyright
Copyright © Cambridge University Press 1984

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References

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