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Study of Gene Expression Profiles and Biological Mechanism of Cerebral Palsy Using a Monozygotic Twin Pair

Published online by Cambridge University Press:  21 February 2012

Tiane Zhang ,
Miqu Wang ,
Ling Pan ,
Weijun Ding ,
J.G. Wang ,
Liping Yang ,
Ming Liu ,
Weihong Li  and
Zhiyong Yan
Tiane Zhang
Affiliation:
Genetics Laboratory, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Miqu Wang
Affiliation:
Genetics Laboratory, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Ling Pan
Affiliation:
Genetics Laboratory, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Weijun Ding
Affiliation:
Genetics Laboratory, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
J.G. Wang*
Affiliation:
Centre for Protective Technology, National University of Singapore, Singapore. cvewjg@nus.edu.sg
Liping Yang
Affiliation:
Genetics Laboratory, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Ming Liu
Affiliation:
Genetics Laboratory, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Weihong Li
Affiliation:
Genetics Laboratory, Chengdu University of Traditional Chinese Medicine, Chengdu, China.
Zhiyong Yan
Affiliation:
School of Pharmaceutical Sciences, Southwest Jiaotong University, Emei, Sichuan, China.
*
*Address for correspondence: Dr Jian-Guo Wang, Centre for Protective Technology, National University of Singapore, 10 Kent Ridge Crescent, Singapore 119260, Singapore.

Abstract

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The gene expression profile of a normal-suffering monozygotic twin pair is investigated to explore biological mechanisms of spastic type cerebral palsy. Main works include following three aspects: First, a cDNA microarray test is carried out to get the differentially expressed genes of the patient with cerebral palsy compared to her monozygotic twin sister. Second, these differentially expressed genes are searched for their bioinformation within 4 biological databases: FatiGO, FatiGOPlus, KEGG, and SOURCE. Third, a set of special genes and gene families are screened out from the spastic type cerebral palsy patient. These biological analyses reveal that those genes for cell junction are mostly down-regulated, while those genes for metabolism are mostly up-regulated. The individual genes, gene family, and their associated biological functions can reflect the pathological and physiological characteristics of the cerebral palsy.

Type
Articles
Information
Twin Research and Human Genetics , Volume 10 , Issue 3 , 01 June 2007 , pp. 496 - 507
Copyright
Copyright © Cambridge University Press 2007