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Serum anti-Müllerian hormone concentrations are related to embryo development: lessons from time-lapse imaging

Published online by Cambridge University Press:  25 September 2023

Amanda Souza Setti Open the ORCID record for Amanda Souza Setti [Opens in a new window] ,
Daniela Paes de Almeida Ferreira Braga ,
Patricia Guilherme ,
Assumpto Iaconelli Jr  and
Edson Borges Jr
Amanda Souza Setti*
Affiliation:
Fertility Medical Group, Av. Brigadeiro Luis Antonio, 4545, São Paulo – SP, Brazil 01401-002 Sapientiae Institute, Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62, São Paulo – SP, Brazil 04503-040
Daniela Paes de Almeida Ferreira Braga
Affiliation:
Fertility Medical Group, Av. Brigadeiro Luis Antonio, 4545, São Paulo – SP, Brazil 01401-002 Sapientiae Institute, Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62, São Paulo – SP, Brazil 04503-040
Patricia Guilherme
Affiliation:
Fertility Medical Group, Av. Brigadeiro Luis Antonio, 4545, São Paulo – SP, Brazil 01401-002
Assumpto Iaconelli Jr
Affiliation:
Fertility Medical Group, Av. Brigadeiro Luis Antonio, 4545, São Paulo – SP, Brazil 01401-002 Sapientiae Institute, Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62, São Paulo – SP, Brazil 04503-040
Edson Borges Jr
Affiliation:
Fertility Medical Group, Av. Brigadeiro Luis Antonio, 4545, São Paulo – SP, Brazil 01401-002 Sapientiae Institute, Centro de Estudos e Pesquisa em Reprodução Humana Assistida, Rua Vieira Maciel, 62, São Paulo – SP, Brazil 04503-040
*
Corresponding author: Amanda Souza Setti; Email: amanda@sapientiae.org.br
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Summary

Our objective was to study whether serum anti-Müllerian hormone (AMH) concentrations were associated with embryo morphokinetic events. This retrospective cohort study was performed in a private university-affiliated in vitro fertilization centre between March 2019 and December 2020 and included 902 oocytes cultured in a time-lapse imaging incubator, obtained from 114 intracytoplasmic sperm injection cycles performed. The relationship between AMH concentrations and morphokinetic events was investigated by considering the clustering of data (multiple embryos/patient). Evaluated kinetic markers were time to pronuclei appearance (tPNa) and fading (tPNf), time to two (t2), three (t3), four (t4), five (t5), six (t6), seven (t7), and eight cells (t8), (tSB) and time to the start of blastulation (tSB) and to blastulation (tB). Significant inverse relationships were observed between serum AMH concentrations and tPNf, t3, t4, t5, t6, t7, t8, and tB. The AMH was positively correlated with the KIDScore and implantation rate. Increased serum AMH concentrations correlated with faster embryo development. The clinical implications of this effect on embryo development warrant further investigation.

Keywords

AMHEmbryo developmentMorphokinetic assessmentOocyte qualityTime-lapse microscopy
Type
Research Article
Information
Zygote , Volume 31 , Issue 6 , December 2023 , pp. 570 - 576
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Copyright
© The Author(s), 2023. Published by Cambridge University Press

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