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Chapter 11 - Lithium

from Part 2 - Psychopharmacology of the Main Psychotropic Drug Groups

Published online by Cambridge University Press:  29 May 2020

By
Allan H. Young  and
Dilveer S. Sually
Edited by
Peter M. Haddad  and
David J. Nutt
Peter M. Haddad
Affiliation:
Hamad Medical Corporation, Qatar
David J. Nutt
Affiliation:
Centre for Neuropsychopharmacology, Division of Psychiatry, Department of Brain Sciences, Imperial College London
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Summary

Lithium is the third element in the periodic table. It was discovered just over 200 years ago in the mineral petalite by the Swedish chemist Arfwedson, and later separated by others (Cogen 2006, Weeks & Larson, 1937). It was initially named lithion (Greek for stone).

Type
Chapter
Information
Seminars in Clinical Psychopharmacology , pp. 350 - 361
Publisher: Cambridge University Press
Print publication year: 2020

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References

Abou-Saleh, MT, Müller-Oerlinghausen, B, Coppen, AJ (2017). Lithium in the episode and suicide prophylaxis and in augmenting strategies in patients with unipolar depression. Int J Bipolar Disord, 5, 11.Google Scholar
Ahrens, B, Müller-Oerlinghausen, B (2001). Does lithium exert an independent antisuicidal effect? Pharmacopsychiatry, 34(4), 132–136.Google Scholar
Aubrey, RE, Scott, L, Cassidy, E (2017). Lithium monitoring patterns in the United Kingdom and Ireland: can shared care agreements play a role in monitoring quality? A systematic review. Ir J Psychol Med, 34, 127–140.CrossRefGoogle Scholar
Baird-Gunning, J, Lea-Henry, T, Hoegberg, LCG, Gosselin, S, Roberts, DM (2017). Lithium poisoning. J Intensive Care Med, 32, 249–263.Google Scholar
Barker, WA, Scott, J, Eccleston, D (1987). The Newcastle chronic depression study: results of a treatment regime. Int Clin Psychopharmacol, 2(3), 261–272.Google Scholar
Bauer, M, Gitlin, M (2016). The Essential Guide to Lithium Treatment. Berlin: Springer International Publishing AG.Google Scholar
Bauer, M, Dell’osso, L, Kasper, S, et al. (2013). Extended-release quetiapine fumarate (quetiapine XR) monotherapy and quetiapine XR or lithium as add-on to antidepressants in patients with treatment-resistant major depressive disorder. J Affect Disord, 151, 209–219.Google Scholar
Bell, AJ, Cole, A, Eccleston, D, Ferrier, IN (1993). Lithium neurotoxicity at normal therapeutic levels. Br J Psychiatry, 162, 689–692.Google Scholar
Beurel, E, Jope, RS (2006). The paradoxical pro- and anti-apoptotic actions of GSK3 in the intrinsic and extrinsic apoptosis signaling pathways. Prog Neurobiol, 79(4), 173–189.CrossRefGoogle ScholarPubMed
Beurel, E, Grieco, SF, Jope, RS (2015). Glycogen synthase kinase-3 (GSK3): regulation, actions, and diseases. Pharmacol Ther, 148, 114–131.CrossRefGoogle ScholarPubMed
BNF (2017). British National Formulary. London: NICE.Google Scholar
Brunello, N, Tascedda, F (2003). Cellular mechanisms and second messengers: relevance to the psychopharmacology of bipolar disorders. Int J Neuropsychopharmacol, 6, 181–189.Google Scholar
Cade, JF (1949). Lithium salts in the treatment of psychotic excitement. Med J Aust, 2, 349–352.CrossRefGoogle ScholarPubMed
Can, A, Schulze, TG, Gould, TD (2014). Molecular actions and clinical pharmacogenetics of lithium therapy. Pharmacol Biochem Behav, 123, 3–16.CrossRefGoogle ScholarPubMed
Cipriani, A, Smith, K, Burgess, S, et al. (2006). Lithium versus antidepressants in the long-term treatment of unipolar affective disorder. Cochrane Database Syst Rev, (4), CD003492.Google Scholar
Cipriani, A, Barbui, C, Salanti, G, et al. (2011). Comparative efficacy and acceptability of antimanic drugs in acute mania: a multiple-treatments meta-analysis. Lancet, 378, 1306–1315.Google Scholar
Cipriani, A, Hawton, K, Stockton, S, Geddes, JR (2013). Lithium in the prevention of suicide in mood disorders: updated systematic review and meta-analysis. BMJ, 346, f3646.Google Scholar
Cleare, A, Pariante, CM, Young, AH, et al. (2015). Evidence-based guidelines for treating depressive disorders with antidepressants: a revision of the 2008 British Association for Psychopharmacology guidelines. J Psychopharmacol, 29, 459–525.CrossRefGoogle ScholarPubMed
Cogen, PH, Whybrow, PC (2006). Lithium: a fascinating element in neuropsychiatry. In Bauer, M, Grof, P, Muller-Oerlinghausen, B, eds., Lithium in Psychiatry: The Comprehensive Guide. London: Informa Healthcare.Google Scholar
Ferrie, L, Young, AH, McQuade, R (2005). Effect of chronic lithium and withdrawal from chronic lithium on presynaptic dopamine function in the rat. J Psychopharmacol, 19(3), 229–234.Google Scholar
Franks, M, Macritchie, KA, Mahmood, T, Young, AH (2008). Bouncing back: is the bipolar rebound phenomenon peculiar to lithium? A retrospective naturalistic study. J Psychopharmacol, 22(4), 452–456. doi:10.1177/0269881107085238.CrossRefGoogle ScholarPubMed
Gershon, S, Chengappa, KN, Malhi, GS (2009). Lithium specificity in bipolar illness: a classic agent for the classic disorder. Bipolar Disord, 11(Suppl 2), 34–44.CrossRefGoogle ScholarPubMed
Ghasemi, M, Dehpour, AR (2011). The NMDA receptor/nitric oxide pathway: a target for the therapeutic and toxic effects of lithium. Trends Pharmacol Sci, 32, 420–434.Google Scholar
Goodwin, GM (1994). Recurrence of mania after lithium withdrawal. Implications for the use of lithium in the treatment of bipolar affective disorder. Br J Psychiatry, 164(2), 149–152.Google Scholar
Goodwin, GM, Haddad, PM, Ferrier, IN, et al. (2016). Evidence-based guidelines for treating bipolar disorder: revised third edition recommendations from the British Association for Psychopharmacology. J Psychopharmacol, 30, 495–553.Google Scholar
Grandjean, EM, Aubry, JM (2009). Lithium: updated human knowledge using an evidence-based approach. Part II: Clinical pharmacology and therapeutic monitoring. CNS Drugs, 23, 331–349.Google Scholar
Hajek, T, Cullis, J, Novak, T, et al. (2012). Hippocampal volumes in bipolar disorders: opposing effects of illness burden and lithium treatment. Bipolar Disord, 14, 261–270.Google Scholar
Hajek, T, Bauer, M, Simhandl, C, et al. (2014). Neuroprotective effect of lithium on hippocampal volumes in bipolar disorder independent of long-term treatment response. Psychol Med, 44, 507–517.CrossRefGoogle ScholarPubMed
Hanson, ND, Nemeroff, CB, Owens, MJ (2011). Lithium, but not fluoxetine or the corticotropin-releasing factor receptor 1 receptor antagonist R121919, increases cell proliferation in the adult dentate gyrus. J Pharmacol Exp Ther, 337, 180–186.Google Scholar
Hayes, JF, Marston, L, Walters, K, et al. (2016a). Lithium vs. valproate vs. olanzapine vs. quetiapine as maintenance monotherapy for bipolar disorder: a population-based UK cohort study using electronic health records. World Psychiatry, 15, 53–58.Google Scholar
Hayes, JF, Pitman, A, Marston, L, et al. (2016b). Self-harm, unintentional injury, and suicide in bipolar disorder during maintenance mood stabilizer treatment: a UK population-based electronic health records study. JAMA Psychiatry, 73(6), 630–637. doi:10.1001/jamapsychiatry.2016.0432.Google Scholar
Jope, RS, Nemeroff, CB (2016). Lithium to the rescue. Cerebrum, 2016, cer-02-16.Google Scholar
Kessing, LV, Sondergard, L, Forman, JL, Andersen, PK (2008). Lithium treatment and risk of dementia. Arch Gen Psychiatry, 65, 1331–1335.Google Scholar
Kessing, LV, Forman, JL, Andersen, PK (2010). Does lithium protect against dementia? Bipolar Disord, 12, 87–94.CrossRefGoogle ScholarPubMed
Kessing, LV, Vradi, E, Andersen, PK (2014). Starting lithium prophylaxis early v. late in bipolar disorder. Br J Psychiatry, 205(3), 214–220. doi:10.1192/bjp.bp.113.142802.CrossRefGoogle ScholarPubMed
Machado-Vieira, R, Gattaz, WF, Zanetti, MV, et al. (2015). A longitudinal (6-week) 3T (1)H-MRS study on the effects of lithium treatment on anterior cingulate cortex metabolites in bipolar depression. Eur Neuropsychopharmacol, 25, 2311–2317.Google Scholar
Malhi, GS, Outhred, T (2016). Therapeutic mechanisms of lithium in bipolar disorder: recent advances and current understanding. CNS Drugs, 30, 931–949.Google Scholar
Malhi, GS, Adams, D, Berk, M (2009). Is lithium in a class of its own? A brief profile of its clinical use. Aust N Z J Psychiatry, 43, 1096–1104.Google Scholar
Malhi, GS, Tanious, M, Das, P, Coulston, CM, Berk, M (2013). Potential mechanisms of action of lithium in bipolar disorder. Current understanding. CNS Drugs, 27(2), 135–153. doi:10.1007/s40263-013-0039-0.Google Scholar
Malhi, GS, Gessler, D, Outhred, T (2017). The use of lithium for the treatment of bipolar disorder: recommendations from clinical practice guidelines. J Affect Disord, 217, 266–280.Google Scholar
Mander, AJ, Loudon, JB (1988). Rapid recurrence of mania following abrupt discontinuation of lithium. Lancet, 2(8601), 15–17.Google Scholar
National Institute for Health and Care Excellence (NICE) (2014). Bipolar disorder: assessment and management. Clinical Guidelines [CG185]. London: National Institute for Health and Care Excellence.Google Scholar
Nolen, WA, Licht, RW, Young, AH, et al.; Task Force on the treatment with lithium (2019). What is the optimal serum level for lithium in the maintenance treatment of bipolar disorder? A systematic review and recommendations from the ISBD/IGSLI Task Force on treatment with lithium. Bipolar Disord, 21(5), 394–409. doi:10.1111/bdi.12805.Google Scholar
Severus, E, Bauer, M, Geddes, J (2018). Efficacy and effectiveness of lithium in the long-term treatment of bipolar disorders: an update 2018. Pharmacopsychiatry, 51(5), 173–176. doi:10.1055/a-0627-7489.Google Scholar
Shelley, R (2004). Affective disorders: 2. Lithium and anticonvulsants. In King, DJ, ed., Seminars in Psychopharmacology, 2nd ed. London: Royal College of Psychiatrists.Google Scholar
Song, J, Sjölander, A, Joas, E, et al. (1917). Suicidal behavior during lithium and valproate treatment: a within-individual 8-year prospective study of 50,000 patients with bipolar disorder. Am J Psychiatry, 174(8), 795–802. doi:10.1176/appi.ajp.2017.16050542.Google Scholar
Taylor, D, Paton, C, Kapur, S (2015). The Maudsley Prescribing Guidelines in Psychiatry, 12th ed. Hoboken: Wiley Blackwell.Google Scholar
Tiihonen, J, Tanskanen, A, Hoti, F, et al. (2017). Pharmacological treatments and risk of readmission to hospital for unipolar depression in Finland: a nationwide cohort study. Lancet Psychiatry, 4(7), 547–553. doi:10.1016/S2215-0366(17)30134-7.Google Scholar
Viguera, AC, Nonacs, R, Cohen, LS, et al. (2000). Risk of recurrence of bipolar disorder in pregnant and nonpregnant women after discontinuing lithium maintenance. Am J Psychiatry, 157, 179–184.Google Scholar
Wakita, M, Nagami, H, Takase, Y, et al. (2015). Modifications of excitatory and inhibitory transmission in rat hippocampal pyramidal neurons by acute lithium treatment. Brain Res Bull, 117, 39–44.Google Scholar
Weeks, ME, Larson, ME (1937). J.A. Arfwedson and his services to chemistry. J Chem Educ, 14, 403–407.Google Scholar
Weisler, RH, Nolen, WA, Neijber, A, Hellqvist, A, Paulsson, B; Trial 144 Study Investigators (2011). Continuation of quetiapine versus switching to placebo or lithium for maintenance treatment of bipolar I disorder (Trial 144: a randomized controlled study). J Clin Psychiatry, 72(11), 1452–1464. doi:10.4088/JCP.11m06878. Erratum in: J Clin Psychiatry 2014, 75(3), 290.CrossRefGoogle ScholarPubMed
World Health Organization (2000). Preventing Suicide: A Resource for General Physicians. Available at: www.who.int/mental_health/media/en/56.pdf (last accessed 22.8.19).Google Scholar
Young, AH (2014). Lithium and suicide. Lancet Psychiatry, 1(6), 483–484. doi:10.1016/S2215-0366(14)70320-7.Google Scholar

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