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Head and Neck Cancer: United Kingdom National Multidisciplinary Guidelines, Sixth Edition
- Jarrod J Homer, Stuart C Winter, Elizabeth C Abbey, Hiba Aga, Reshma Agrawal, Derfel ap Dafydd, Takhar Arunjit, Patrick Axon, Eleanor Aynsley, Izhar N Bagwan, Arun Batra, Donna Begg, Jonathan M Bernstein, Guy Betts, Colin Bicknell, Brian Bisase, Grainne C Brady, Peter Brennan, Aina Brunet, Val Bryant, Linda Cantwell, Ashish Chandra, Preetha Chengot, Melvin L K Chua, Peter Clarke, Gemma Clunie, Margaret Coffey, Clare Conlon, David I Conway, Florence Cook, Matthew R Cooper, Declan Costello, Ben Cosway, Neil J A Cozens, Grant Creaney, Daljit K Gahir, Stephen Damato, Joe Davies, Katharine S Davies, Alina D Dragan, Yong Du, Mark R D Edmond, Stefano Fedele, Harriet Finze, Jason C Fleming, Bernadette H Foran, Beth Fordham, Mohammed M A S Foridi, Lesley Freeman, Katherine E Frew, Pallavi Gaitonde, Victoria Gallyer, Fraser W Gibb, Sinclair M Gore, Mark Gormley, Roganie Govender, J Greedy, Teresa Guerrero Urbano, Dorothy Gujral, David W Hamilton, John C Hardman, Kevin Harrington, Samantha Holmes, Jarrod J Homer, Deborah Howland, Gerald Humphris, Keith D Hunter, Kate Ingarfield, Richard Irving, Kristina Isand, Yatin Jain, Sachin Jauhar, Sarra Jawad, Glyndwr W Jenkins, Anastasios Kanatas, Stephen Keohane, Cyrus J Kerawala, William Keys, Emma V King, Anthony Kong, Fiona Lalloo, Kirsten Laws, Samuel C Leong, Shane Lester, Miles Levy, Ken Lingley, Gitta Madani, Navin Mani, Paolo L Matteucci, Catriona R Mayland, James McCaul, Lorna K McCaul, Pádraig McDonnell, Andrew McPartlin, Valeria Mercadante, Zoe Merchant, Radu Mihai, Mufaddal T Moonim, John Moore, Paul Nankivell, Sonali Natu, A Nelson, Pablo Nenclares, Kate Newbold, Carrie Newland, Ailsa J Nicol, Iain J Nixon, Rupert Obholzer, James T O'Hara, S Orr, Vinidh Paleri, James Palmer, Rachel S Parry, Claire Paterson, Gillian Patterson, Joanne M Patterson, Miranda Payne, L Pearson, David N Poller, Jonathan Pollock, Stephen Ross Porter, Matthew Potter, Robin J D Prestwich, Ruth Price, Mani Ragbir, Meena S Ranka, Max Robinson, Justin W G Roe, Tom Roques, Aleix Rovira, Sajid Sainuddin, I J Salmon, Ann Sandison, Andy Scarsbrook, Andrew G Schache, A Scott, Diane Sellstrom, Cherith J Semple, Jagrit Shah, Praveen Sharma, Richard J Shaw, Somiah Siddiq, Priyamal Silva, Ricard Simo, Rabin P Singh, Maria Smith, Rebekah Smith, Toby Oliver Smith, Sanjai Sood, Francis W Stafford, Neil Steven, Kay Stewart, Lisa Stoner, Steve Sweeney, Andrew Sykes, Carly L Taylor, Selvam Thavaraj, David J Thomson, Jane Thornton, Neil S Tolley, Nancy Turnbull, Sriram Vaidyanathan, Leandros Vassiliou, John Waas, Kelly Wade-McBane, Donna Wakefield, Amy Ward, Laura Warner, Laura-Jayne Watson, H Watts, Christina Wilson, Stuart C Winter, Winson Wong, Chui-Yan Yip, Kent Yip
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- Journal:
- The Journal of Laryngology & Otology / Volume 138 / Issue S1 / April 2024
- Published online by Cambridge University Press:
- 14 March 2024, pp. S1-S224
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- April 2024
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The predictive role of symptoms in COVID-19 diagnostic models: A longitudinal insight
- Olivia Bird, Eva P. Galiza, David Neil Baxter, Marta Boffito, Duncan Browne, Fiona Burns, David R. Chadwick, Rebecca Clark, Catherine A. Cosgrove, James Galloway, Anna L. Goodman, Amardeep Heer, Andrew Higham, Shalini Iyengar, Christopher Jeanes, Philip A. Kalra, Christina Kyriakidou, Judy M. Bradley, Chigomezgo Munthali, Angela M. Minassian, Fiona McGill, Patrick Moore, Imrozia Munsoor, Helen Nicholls, Orod Osanlou, Jonathan Packham, Carol H. Pretswell, Alberto San Francisco Ramos, Dinesh Saralaya, Ray P. Sheridan, Richard Smith, Roy L. Soiza, Pauline A. Swift, Emma C. Thomson, Jeremy Turner, Marianne Elizabeth Viljoen, Paul T. Heath, Irina Chis Ster
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- Journal:
- Epidemiology & Infection / Volume 152 / 2024
- Published online by Cambridge University Press:
- 22 January 2024, e37
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To investigate the symptoms of SARS-CoV-2 infection, their dynamics and their discriminatory power for the disease using longitudinally, prospectively collected information reported at the time of their occurrence. We have analysed data from a large phase 3 clinical UK COVID-19 vaccine trial. The alpha variant was the predominant strain. Participants were assessed for SARS-CoV-2 infection via nasal/throat PCR at recruitment, vaccination appointments, and when symptomatic. Statistical techniques were implemented to infer estimates representative of the UK population, accounting for multiple symptomatic episodes associated with one individual. An optimal diagnostic model for SARS-CoV-2 infection was derived. The 4-month prevalence of SARS-CoV-2 was 2.1%; increasing to 19.4% (16.0%–22.7%) in participants reporting loss of appetite and 31.9% (27.1%–36.8%) in those with anosmia/ageusia. The model identified anosmia and/or ageusia, fever, congestion, and cough to be significantly associated with SARS-CoV-2 infection. Symptoms’ dynamics were vastly different in the two groups; after a slow start peaking later and lasting longer in PCR+ participants, whilst exhibiting a consistent decline in PCR- participants, with, on average, fewer than 3 days of symptoms reported. Anosmia/ageusia peaked late in confirmed SARS-CoV-2 infection (day 12), indicating a low discrimination power for early disease diagnosis.
How Incarcerating Children Affects their Labour Market Outcomes
- Richard Dorsett, David Thomson
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- Journal:
- Journal of Social Policy , First View
- Published online by Cambridge University Press:
- 29 May 2023, pp. 1-22
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We investigate the labour market effects of incarcerating children. Using linked administrative data to track outcomes for English schoolchildren, we estimate an econometric model of transitions between education, custody, employment and NEET (not in employment, education or training), along with earnings for those starting work. We allow outcomes to vary according to the individual’s state in the preceding spell and, by controlling for personal characteristics and unobserved heterogeneity, interpret such variation as capturing causal impacts. For males, the main effect of incarceration is a reduction of more than 10% in the probability of employment. For females, there is no overall impact on employment but, for those entering work, wages are reduced by 25%. These negative impacts suggest roles for policy in deterring delinquency, finding alternatives to custody, rehabilitating those incarcerated and supporting resettlement on release. Appropriate labour market policy may differ by gender, with males needing help to overcome employer discrimination and females needing encouragement to achieve better-paid work.
Who excludes? Young People’s Experience of Social Exclusion
- GERRY REDMOND, GILL MAIN, ALEXANDER W. O’DONNELL, JENNIFER SKATTEBOL, RICHARD WOODMAN, ANNA MOONEY, JOANNA WANG, SABERA TURKMANI, CATHERINE THOMSON, FIONA BROOKS
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- Journal:
- Journal of Social Policy / Volume 53 / Issue 1 / January 2024
- Published online by Cambridge University Press:
- 24 February 2022, pp. 236-259
- Print publication:
- January 2024
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Existing policy research has not comprehensively examined the processes by which young people experience social exclusion: that is, the relationships among different risk factors for exclusion, their actual experiences of exclusion, and outcomes that matter for their life chances. Drawing on data from a survey of Australian 13-14 year olds (N=3,535), this paper adapts the Bristol Social Exclusion Matrix to examine pathways from young people’s personal and family resources, their experience of participation (school engagement; bullying victimization; teacher support), and their life satisfaction – a predictive indicator of wellbeing and mental health in adulthood. The effects of other characteristics or risk factors for young people’s social exclusion (living with disability, being a young carer, identifying as Indigenous, and speaking a language other than English at home), are also examined. This paper shows that experience of exclusion mediates the relationship between young people’s personal and family resources and life satisfaction. Controlling for characteristics or risk factors does not change this relationship, suggesting that processes of social exclusion, enacted in interpersonal encounters, are driven by overarching structural factors. These findings are relevant for policy in Australia, and in other countries with similar policy regimes.
Our Changing World-View
- Ten Lectures on Recent Movements of Thought in Science, Economics, Education, Literature and Philosophy
- Robert Broom, John Patrick Dalton, John Young Thomson Greig, Theodorus Johannes Haarhof, Reinhold Frederick Alfred Hoernlé, Sally Herbert Frankel, Ian D. MacCrone, John Frederick Vicars Phillips, Cecil Sydney Richards, Jan Christian Smuts, Saul Dubow
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- Published by:
- Wits University Press
- Published online:
- 12 October 2021
- Print publication:
- 01 August 2021
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Johannesburg was still a brash mining town, better known for the production of wealth than knowledge, and the University of the Witwatersrand a mere ten years old when, in 1932, these ten lectures were delivered under the auspices of the University Philosophical Society. They portrayed the ideas of the university's leading academics of the day, and the programme of lectures reveals a studied effort to introduce an element of bipartisan political representation between English and Afrikaner in South Africa by including Wits' first principal, Jan Hofmeyr, and politician, D.F. Malan, as discussion chairs. Yet, no black intellectuals were represented and, indeed, the politics of racial segregation bursts through the text only in a few of the contributions. For the most part, race is alluded to only in passing. As Saul Dubow explains in his new introduction to this re-issue of the lectures, Our Changing World-View was an occasion for Wits' leading faculty members to position the young university as a mature institution with a leadership role in public affairs. Above all, it was a means to project the university as a research as well as a teaching institution, led by a vigorous and ambitious cohort of liberal-minded intellectuals. That all were male and white will be immediately apparent to readers of this reissued volume. Ranging from economics, psychology, a spurious rebuttal of evolution to a substantial revisionist history and the perils of the 'machine age', this book is a sombre reflection of intellectual history and the academy's role in promulgating political and social divisions in South Africa.
Miscellaneous Frontmatter
- Robert Broom, John Patrick Dalton, John Young Thomson Greig, Theodorus Johannes Haarhof, Reinhold Frederick Alfred Hoernlé, Sally Herbert Frankel, Ian D. MacCrone, John Frederick Vicars Phillips, Cecil Sydney Richards, Jan Christian Smuts, Saul Dubow
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- Book:
- Our Changing World-View
- Published by:
- Wits University Press
- Published online:
- 12 October 2021
- Print publication:
- 01 August 2021, pp xix-xxii
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Contents
- Robert Broom, John Patrick Dalton, John Young Thomson Greig, Theodorus Johannes Haarhof, Reinhold Frederick Alfred Hoernlé, Sally Herbert Frankel, Ian D. MacCrone, John Frederick Vicars Phillips, Cecil Sydney Richards, Jan Christian Smuts, Saul Dubow
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- Our Changing World-View
- Published by:
- Wits University Press
- Published online:
- 12 October 2021
- Print publication:
- 01 August 2021, pp v-vi
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Frontmatter
- Robert Broom, John Patrick Dalton, John Young Thomson Greig, Theodorus Johannes Haarhof, Reinhold Frederick Alfred Hoernlé, Sally Herbert Frankel, Ian D. MacCrone, John Frederick Vicars Phillips, Cecil Sydney Richards, Jan Christian Smuts, Saul Dubow
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- Book:
- Our Changing World-View
- Published by:
- Wits University Press
- Published online:
- 12 October 2021
- Print publication:
- 01 August 2021, pp i-iv
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11 - Choosing treatments and the role of shared decision-making
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- By <span class='sc'>France</span> <span class='sc'>Légaré</span>, <span class='sc'>Martin</span> <span class='sc'>Härter</span>, <span class='sc'>Anne M.</span> <span class='sc'>Stiggelbout</span>, <span class='sc'>Richard</span> <span class='sc'>Thomson</span>, <span class='sc'>Dawn</span> <span class='sc'>Stacey</span>
- Edited by Ellen Nolte, London School of Hygiene and Tropical Medicine, Sherry Merkur, Anders Anell, Lunds Universitet, Sweden
- Assisted by Jonathan North
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- Book:
- Achieving Person-Centred Health Systems
- Published online:
- 10 July 2020
- Print publication:
- 06 August 2020, pp 283-316
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Summary
In 2015 people in OECD countries consulted a medical practitioner between two and sixteen times (OECD, 2015). These care-seekers were once expected to go along with whatever the doctor decided was best, but this has been slowly changing since the 1970s. As highlighted in Chapter 2 of this book, growing awareness of the limits of medical interventions and of the lack of control over decisions about one’s own care (Illich, 1975) led to calls for equality between the patient and the health professional towards establishing a partnership for making decisions and determining the direction of care.
The notion of a more participatory approach to informed decision-making was first proposed by Robert Veatch in 1972, who suggested the idea of “sharing of decision-making” (Veatch, 1972). Evidence was accumulating that where doctors and patients agreed on the problem, outcomes were better (Starfield et al., 1979).
5 - Diamonds and the Mantle Geodynamics of Carbon
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- By Steven B. Shirey, Karen V. Smit, D. Graham Pearson, Michael J. Walter, Sonja Aulbach, Frank E. Brenker, Hélène Bureau, Antony D. Burnham, Pierre Cartigny, Thomas Chacko, Daniel J. Frost, Erik H. Hauri, Dorrit E. Jacob, Steven D. Jacobsen, Simon C. Kohn, Robert W. Luth, Sami Mikhail, Oded Navon, Fabrizio Nestola, Paolo Nimis, Mederic Palot, Evan M. Smith, Thomas Stachel, Vincenzo Stagno, Andrew Steele, Richard A. Stern, Emilie Thomassot, Andrew R. Thomson, Yaakov Weiss
- Edited by Beth N. Orcutt, Isabelle Daniel, Université Claude-Bernard Lyon I, Rajdeep Dasgupta, Rice University, Houston
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- Book:
- Deep Carbon
- Published online:
- 03 October 2019
- Print publication:
- 17 October 2019, pp 89-128
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Summary
The science of studying diamond inclusions for understanding Earth history has developed significantly over the past decades, with new instrumentation and techniques applied to diamond sample archives revealing the stories contained within diamond inclusions. This chapter reviews what diamonds can tell us about the deep carbon cycle over the course of Earth’s history. It reviews how the geochemistry of diamonds and their inclusions inform us about the deep carbon cycle, the origin of the diamonds in Earth’s mantle, and the evolution of diamonds through time.
Stevenson as Essayist
- R. L. Stevenson
- Edited by Robert-Louis Arbrahamson
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- Book:
- Essays I
- Published by:
- Edinburgh University Press
- Published online:
- 11 November 2020
- Print publication:
- 06 June 2018, pp xxxiii-lxviii
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Summary
DEFINITION OF ‘ESSAY’
The essay is a short non-fictional prose composition, characterized by an exploratory approach to its subject. In its archetypical form in Montaigne it follows the line of the writer's thought, built in part out of quotation and reference to earlier authorities, often about some overlooked everyday phenomenon, adopting a confidential relationship with the reader and creating a distinctive personality for the writer. The genre excludes the long narratives of history and autobiography, as well as prose with the practical aim of persuasion or denunciation.
Such archetypal essays are often called ‘familiar’ or ‘personal essays’. In contrast, the ‘formal essay’ has less focus on the writer and style, personal memories and observations. Nevertheless, the formal essay is still exploratory and is therefore distinct from the more methodologically rigorous treatise or the scientific paper.
Stevenson himself applies the term to a variety of writing, including the short pensée (in ‘Essays, Reflections and Remarks on Human Life’), the paper for debate read to a university debating society, the treatise-like ‘Lay Morals’, his planned study of ‘The Transformation of the Highlands’ after 1745 (which he thinks will turn into ‘a long essay’; Letters 3: 129), and a planned work of comparative literary history (‘Ramsay, Fergusson and Burns: An Essay’; Letters 2: 165). He even uses the word to describe Kidnapped, meaning an experiment, a sketch: it is ‘no work, only an essay’ (Letters 5: 314).
Nevertheless, his normal use of ‘essay’ corresponds to the consensus definition. It is true that he sometimes makes a distinction between ‘essays’ and ‘studies’: freely wandering familiar essays and more focussed literary and historical studies. The former type, familiar essays proper, include those collected in Virginibus Puerisque and Memories and Portraits, which he considered re-issuing together in 1887 as Familiar Essays I and II (Letters 5: 436), implicitly distinguishing them from the essays in the 1882 volume Familiar Studies of Men and Books. These he refers to in the Preface to the volume only as ‘studies’, never as ‘essays’, and elsewhere refers to such works as ‘critical essays’ or ‘critical papers’ (Letters 2: 165, 5: 217, 6: 142), and the distinction of familiar essays and studies continues in his planning for the Edinburgh Edition (Letters 8: 225).
Siliceous microfossil record of late Holocene oceanography and climate along the west coast of Vancouver Island, British Columbia (Canada)
- Murray B. Hay, Audrey Dallimore, Richard E. Thomson, Stephen E. Calvert, Reinhard Pienitz
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- Journal:
- Quaternary Research / Volume 67 / Issue 1 / January 2007
- Published online by Cambridge University Press:
- 20 January 2017, pp. 33-49
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Diatoms, silicoflagellates, and biogenic silica (BSi) were analyzed from two piston cores recovered from Effingham Inlet, British Columbia. Relatively productive marine conditions from 4850 to 4000 cal yr BP were followed by a transition to the modern ocean–climate regime marked by a decreased siliceous microfossil production since 2800 cal yr BP. This change in the northeast Pacific climate was characterized by an apparent cooling associated with higher rainfall and lower light levels. The reduced abundance of most spring–summer bloom diatom taxa (Skeletonema–Thalassiosira–Chaetoceros) was coupled with a decreased abundance of diatoms normally associated with incursions of offshore water into coastal inlets. This pattern reflected a weaker summer upwelling along Vancouver Island associated with the insolation-related increase in the strength of the Aleutian Low and a weakened North Pacific High. After ca. 2800 cal yr BP, diatom assemblages also indicated more frequent periods of relatively low spring–summer surface water salinity and a disruption of the typical bloom sequence, indicative of increased climatic variability. A period of warmer and drier climate conditions and possibly increased coastal upwelling offshore occurred ca. 1450–1050 cal yr BP. The most recent 500 yr are marked by reduced diatom production and the appearance of three distinct diatom biomarkers in the stratigraphic record (Rhizosolenia setigera ca. AD 1940; Minidiscus chilensis ca. AD 1860; Thalassionema nitzschioides morphotype A, ca. AD 1550). The oceanographic changes recorded in Effingham Inlet are correlative with other marine and terrestrial paleoenvironmental records in the northeast Pacific Ocean.
Contributors
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- By Mitchell Aboulafia, Frederick Adams, Marilyn McCord Adams, Robert M. Adams, Laird Addis, James W. Allard, David Allison, William P. Alston, Karl Ameriks, C. Anthony Anderson, David Leech Anderson, Lanier Anderson, Roger Ariew, David Armstrong, Denis G. Arnold, E. J. Ashworth, Margaret Atherton, Robin Attfield, Bruce Aune, Edward Wilson Averill, Jody Azzouni, Kent Bach, Andrew Bailey, Lynne Rudder Baker, Thomas R. Baldwin, Jon Barwise, George Bealer, William Bechtel, Lawrence C. Becker, Mark A. Bedau, Ernst Behler, José A. Benardete, Ermanno Bencivenga, Jan Berg, Michael Bergmann, Robert L. Bernasconi, Sven Bernecker, Bernard Berofsky, Rod Bertolet, Charles J. Beyer, Christian Beyer, Joseph Bien, Joseph Bien, Peg Birmingham, Ivan Boh, James Bohman, Daniel Bonevac, Laurence BonJour, William J. Bouwsma, Raymond D. Bradley, Myles Brand, Richard B. Brandt, Michael E. Bratman, Stephen E. Braude, Daniel Breazeale, Angela Breitenbach, Jason Bridges, David O. Brink, Gordon G. Brittan, Justin Broackes, Dan W. Brock, Aaron Bronfman, Jeffrey E. Brower, Bartosz Brozek, Anthony Brueckner, Jeffrey Bub, Lara Buchak, Otavio Bueno, Ann E. Bumpus, Robert W. Burch, John Burgess, Arthur W. Burks, Panayot Butchvarov, Robert E. Butts, Marina Bykova, Patrick Byrne, David Carr, Noël Carroll, Edward S. Casey, Victor Caston, Victor Caston, Albert Casullo, Robert L. Causey, Alan K. L. Chan, Ruth Chang, Deen K. Chatterjee, Andrew Chignell, Roderick M. Chisholm, Kelly J. Clark, E. J. Coffman, Robin Collins, Brian P. Copenhaver, John Corcoran, John Cottingham, Roger Crisp, Frederick J. Crosson, Antonio S. Cua, Phillip D. Cummins, Martin Curd, Adam Cureton, Andrew Cutrofello, Stephen Darwall, Paul Sheldon Davies, Wayne A. Davis, Timothy Joseph Day, Claudio de Almeida, Mario De Caro, Mario De Caro, John Deigh, C. F. Delaney, Daniel C. Dennett, Michael R. DePaul, Michael Detlefsen, Daniel Trent Devereux, Philip E. Devine, John M. Dillon, Martin C. Dillon, Robert DiSalle, Mary Domski, Alan Donagan, Paul Draper, Fred Dretske, Mircea Dumitru, Wilhelm Dupré, Gerald Dworkin, John Earman, Ellery Eells, Catherine Z. Elgin, Berent Enç, Ronald P. Endicott, Edward Erwin, John Etchemendy, C. Stephen Evans, Susan L. Feagin, Solomon Feferman, Richard Feldman, Arthur Fine, Maurice A. Finocchiaro, William FitzPatrick, Richard E. Flathman, Gvozden Flego, Richard Foley, Graeme Forbes, Rainer Forst, Malcolm R. Forster, Daniel Fouke, Patrick Francken, Samuel Freeman, Elizabeth Fricker, Miranda Fricker, Michael Friedman, Michael Fuerstein, Richard A. Fumerton, Alan Gabbey, Pieranna Garavaso, Daniel Garber, Jorge L. A. Garcia, Robert K. Garcia, Don Garrett, Philip Gasper, Gerald Gaus, Berys Gaut, Bernard Gert, Roger F. Gibson, Cody Gilmore, Carl Ginet, Alan H. Goldman, Alvin I. Goldman, Alfonso Gömez-Lobo, Lenn E. Goodman, Robert M. Gordon, Stefan Gosepath, Jorge J. E. Gracia, Daniel W. Graham, George A. Graham, Peter J. Graham, Richard E. Grandy, I. Grattan-Guinness, John Greco, Philip T. Grier, Nicholas Griffin, Nicholas Griffin, David A. Griffiths, Paul J. Griffiths, Stephen R. Grimm, Charles L. Griswold, Charles B. Guignon, Pete A. Y. Gunter, Dimitri Gutas, Gary Gutting, Paul Guyer, Kwame Gyekye, Oscar A. Haac, Raul Hakli, Raul Hakli, Michael Hallett, Edward C. Halper, Jean Hampton, R. James Hankinson, K. R. Hanley, Russell Hardin, Robert M. Harnish, William Harper, David Harrah, Kevin Hart, Ali Hasan, William Hasker, John Haugeland, Roger Hausheer, William Heald, Peter Heath, Richard Heck, John F. Heil, Vincent F. Hendricks, Stephen Hetherington, Francis Heylighen, Kathleen Marie Higgins, Risto Hilpinen, Harold T. Hodes, Joshua Hoffman, Alan Holland, Robert L. Holmes, Richard Holton, Brad W. Hooker, Terence E. Horgan, Tamara Horowitz, Paul Horwich, Vittorio Hösle, Paul Hoβfeld, Daniel Howard-Snyder, Frances Howard-Snyder, Anne Hudson, Deal W. Hudson, Carl A. Huffman, David L. Hull, Patricia Huntington, Thomas Hurka, Paul Hurley, Rosalind Hursthouse, Guillermo Hurtado, Ronald E. Hustwit, Sarah Hutton, Jonathan Jenkins Ichikawa, Harry A. Ide, David Ingram, Philip J. Ivanhoe, Alfred L. Ivry, Frank Jackson, Dale Jacquette, Joseph Jedwab, Richard Jeffrey, David Alan Johnson, Edward Johnson, Mark D. Jordan, Richard Joyce, Hwa Yol Jung, Robert Hillary Kane, Tomis Kapitan, Jacquelyn Ann K. Kegley, James A. Keller, Ralph Kennedy, Sergei Khoruzhii, Jaegwon Kim, Yersu Kim, Nathan L. King, Patricia Kitcher, Peter D. Klein, E. D. Klemke, Virginia Klenk, George L. Kline, Christian Klotz, Simo Knuuttila, Joseph J. Kockelmans, Konstantin Kolenda, Sebastian Tomasz Kołodziejczyk, Isaac Kramnick, Richard Kraut, Fred Kroon, Manfred Kuehn, Steven T. Kuhn, Henry E. Kyburg, John Lachs, Jennifer Lackey, Stephen E. Lahey, Andrea Lavazza, Thomas H. Leahey, Joo Heung Lee, Keith Lehrer, Dorothy Leland, Noah M. Lemos, Ernest LePore, Sarah-Jane Leslie, Isaac Levi, Andrew Levine, Alan E. Lewis, Daniel E. Little, Shu-hsien Liu, Shu-hsien Liu, Alan K. L. Chan, Brian Loar, Lawrence B. Lombard, John Longeway, Dominic McIver Lopes, Michael J. Loux, E. J. Lowe, Steven Luper, Eugene C. Luschei, William G. Lycan, David Lyons, David Macarthur, Danielle Macbeth, Scott MacDonald, Jacob L. Mackey, Louis H. Mackey, Penelope Mackie, Edward H. Madden, Penelope Maddy, G. B. Madison, Bernd Magnus, Pekka Mäkelä, Rudolf A. Makkreel, David Manley, William E. Mann (W.E.M.), Vladimir Marchenkov, Peter Markie, Jean-Pierre Marquis, Ausonio Marras, Mike W. Martin, A. P. Martinich, William L. McBride, David McCabe, Storrs McCall, Hugh J. McCann, Robert N. McCauley, John J. McDermott, Sarah McGrath, Ralph McInerny, Daniel J. McKaughan, Thomas McKay, Michael McKinsey, Brian P. McLaughlin, Ernan McMullin, Anthonie Meijers, Jack W. Meiland, William Jason Melanson, Alfred R. Mele, Joseph R. Mendola, Christopher Menzel, Michael J. Meyer, Christian B. Miller, David W. Miller, Peter Millican, Robert N. Minor, Phillip Mitsis, James A. Montmarquet, Michael S. Moore, Tim Moore, Benjamin Morison, Donald R. Morrison, Stephen J. Morse, Paul K. Moser, Alexander P. D. Mourelatos, Ian Mueller, James Bernard Murphy, Mark C. Murphy, Steven Nadler, Jan Narveson, Alan Nelson, Jerome Neu, Samuel Newlands, Kai Nielsen, Ilkka Niiniluoto, Carlos G. Noreña, Calvin G. Normore, David Fate Norton, Nikolaj Nottelmann, Donald Nute, David S. Oderberg, Steve Odin, Michael O’Rourke, Willard G. Oxtoby, Heinz Paetzold, George S. Pappas, Anthony J. Parel, Lydia Patton, R. P. Peerenboom, Francis Jeffry Pelletier, Adriaan T. Peperzak, Derk Pereboom, Jaroslav Peregrin, Glen Pettigrove, Philip Pettit, Edmund L. Pincoffs, Andrew Pinsent, Robert B. Pippin, Alvin Plantinga, Louis P. Pojman, Richard H. Popkin, John F. Post, Carl J. Posy, William J. Prior, Richard Purtill, Michael Quante, Philip L. Quinn, Philip L. Quinn, Elizabeth S. Radcliffe, Diana Raffman, Gerard Raulet, Stephen L. Read, Andrews Reath, Andrew Reisner, Nicholas Rescher, Henry S. Richardson, Robert C. Richardson, Thomas Ricketts, Wayne D. Riggs, Mark Roberts, Robert C. Roberts, Luke Robinson, Alexander Rosenberg, Gary Rosenkranz, Bernice Glatzer Rosenthal, Adina L. Roskies, William L. Rowe, T. M. Rudavsky, Michael Ruse, Bruce Russell, Lilly-Marlene Russow, Dan Ryder, R. M. Sainsbury, Joseph Salerno, Nathan Salmon, Wesley C. Salmon, Constantine Sandis, David H. Sanford, Marco Santambrogio, David Sapire, Ruth A. Saunders, Geoffrey Sayre-McCord, Charles Sayward, James P. Scanlan, Richard Schacht, Tamar Schapiro, Frederick F. Schmitt, Jerome B. Schneewind, Calvin O. Schrag, Alan D. Schrift, George F. Schumm, Jean-Loup Seban, David N. Sedley, Kenneth Seeskin, Krister Segerberg, Charlene Haddock Seigfried, Dennis M. Senchuk, James F. Sennett, William Lad Sessions, Stewart Shapiro, Tommie Shelby, Donald W. Sherburne, Christopher Shields, Roger A. Shiner, Sydney Shoemaker, Robert K. Shope, Kwong-loi Shun, Wilfried Sieg, A. John Simmons, Robert L. Simon, Marcus G. Singer, Georgette Sinkler, Walter Sinnott-Armstrong, Matti T. Sintonen, Lawrence Sklar, Brian Skyrms, Robert C. Sleigh, Michael Anthony Slote, Hans Sluga, Barry Smith, Michael Smith, Robin Smith, Robert Sokolowski, Robert C. Solomon, Marta Soniewicka, Philip Soper, Ernest Sosa, Nicholas Southwood, Paul Vincent Spade, T. L. S. Sprigge, Eric O. Springsted, George J. Stack, Rebecca Stangl, Jason Stanley, Florian Steinberger, Sören Stenlund, Christopher Stephens, James P. Sterba, Josef Stern, Matthias Steup, M. A. Stewart, Leopold Stubenberg, Edith Dudley Sulla, Frederick Suppe, Jere Paul Surber, David George Sussman, Sigrún Svavarsdóttir, Zeno G. Swijtink, Richard Swinburne, Charles C. Taliaferro, Robert B. Talisse, John Tasioulas, Paul Teller, Larry S. Temkin, Mark Textor, H. S. Thayer, Peter Thielke, Alan Thomas, Amie L. Thomasson, Katherine Thomson-Jones, Joshua C. Thurow, Vzalerie Tiberius, Terrence N. Tice, Paul Tidman, Mark C. Timmons, William Tolhurst, James E. Tomberlin, Rosemarie Tong, Lawrence Torcello, Kelly Trogdon, J. D. Trout, Robert E. Tully, Raimo Tuomela, John Turri, Martin M. Tweedale, Thomas Uebel, Jennifer Uleman, James Van Cleve, Harry van der Linden, Peter van Inwagen, Bryan W. Van Norden, René van Woudenberg, Donald Phillip Verene, Samantha Vice, Thomas Vinci, Donald Wayne Viney, Barbara Von Eckardt, Peter B. M. Vranas, Steven J. Wagner, William J. Wainwright, Paul E. Walker, Robert E. Wall, Craig Walton, Douglas Walton, Eric Watkins, Richard A. Watson, Michael V. Wedin, Rudolph H. Weingartner, Paul Weirich, Paul J. Weithman, Carl Wellman, Howard Wettstein, Samuel C. Wheeler, Stephen A. White, Jennifer Whiting, Edward R. Wierenga, Michael Williams, Fred Wilson, W. Kent Wilson, Kenneth P. Winkler, John F. Wippel, Jan Woleński, Allan B. Wolter, Nicholas P. Wolterstorff, Rega Wood, W. Jay Wood, Paul Woodruff, Alison Wylie, Gideon Yaffe, Takashi Yagisawa, Yutaka Yamamoto, Keith E. Yandell, Xiaomei Yang, Dean Zimmerman, Günter Zoller, Catherine Zuckert, Michael Zuckert, Jack A. Zupko (J.A.Z.)
- Edited by Robert Audi, University of Notre Dame, Indiana
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- The Cambridge Dictionary of Philosophy
- Published online:
- 05 August 2015
- Print publication:
- 27 April 2015, pp ix-xxx
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Dichoptic Viewing Methods for Binocular Rivalry Research: Prospects for Large-Scale Clinical and Genetic Studies
- Phillip C. F. Law, Bryan K. Paton, Richard H. Thomson, Guang B. Liu, Steven M. Miller, Trung T. Ngo
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- Journal:
- Twin Research and Human Genetics / Volume 16 / Issue 6 / December 2013
- Published online by Cambridge University Press:
- 25 November 2013, pp. 1033-1078
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Binocular rivalry (BR) is an intriguing phenomenon that occurs when two different images are presented, one to each eye, resulting in alternation or rivalry between the percepts. The phenomenon has been studied for nearly 200 years, with renewed and intensive investigation over recent decades. The rate of perceptual switching has long been known to vary widely between individuals but to be relatively stable within individuals. A recent twin study demonstrated that individual variation in BR rate is under substantial genetic control, a finding that also represented the first report, using a large study, of genetic contribution for any post-retinal visual processing phenomenon. The twin study had been prompted by earlier work showing BR rate was slow in the heritable psychiatric condition, bipolar disorder (BD). Together, these studies suggested that slow BR may represent an endophenotype for BD, and heralded the advent of modern clinical and genetic studies of rivalry. This new focus has coincided with rapid advances in 3D display technology, but despite such progress, specific development of technology for rivalry research has been lacking. This review therefore compares different display methods for BR research across several factors, including viewing parameters, image quality, equipment cost, compatibility with other investigative methods, subject group, and sample size, with a focus on requirements specific to large-scale clinical and genetic studies. It is intended to be a resource for investigators new to BR research, such as clinicians and geneticists, and to stimulate the development of 3D display technology for advancing interdisciplinary studies of rivalry.
Outcome and patient-reported toxicity in localised prostate cancer treated with dose-escalated hypofractionated intensity-modulated radiotherapy
- David Thomson, Sophie Merrick, Ric Swindell, James Wylie, Richard Cowan, Tony Elliott, John Logue, Jacqueline Livsey, Ananya Choudhury
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- Journal:
- Journal of Radiotherapy in Practice / Volume 12 / Issue 4 / December 2013
- Published online by Cambridge University Press:
- 23 April 2013, pp. 326-333
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Objective
To report outcomes and late toxicity for a hypofractionated dose-escalated radiotherapy schedule in patients treated using intensity-modulated radiotherapy (IMRT) for localised prostate cancer.
Materials and methodsEighty-eight men with localised prostate cancer were treated with 57 Gy in 19 daily fractions over 4 weeks. A total of 70 out of 88 had high-risk disease. Overall survival, cause-specific survival and biochemical progression-free survival (bPFS, Phoenix definition) were reported. Toxicity was measured retrospectively using Radiation Therapy Oncology Group (RTOG) criteria and assessed prospectively with a validated Late Effects in Normal Tissues Subjective, Objective, Management and Analytic (LENT/SOMA) patient questionnaire.
ResultsAt 5 years, overall survival was 84%, cause-specific survival 88% and bPFS 65%. In patients with high-risk disease, 5-year bPFS was 62%. There was no RTOG toxicity above grade III. LENT/SOMA questionnaires were returned by 74% patients. Median scores for bowel and urinary function were <1. Maximum bowel and urinary toxicity scores ≥2 were reported by 64% and 59% of patients, respectively. The median score for sexual function was 1·5, but nearly all (96%) patients recorded a toxicity score ≥2 for at least one question.
ConclusionsDose-escalated hypofractionated radiotherapy delivered using IMRT has promising outcomes and acceptable late toxicity. This fractionation schedule is being compared with conventional treatment within an on-going multicentre phase III clinical trial.
Contributors
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- By Federico Agliardi, Andrea Alpiger, Gianluca Bianchi Fasani, Lars Harald Blikra, Brian D. Bornhold, Edward N. Bromhead, Marko H.K. Bulmer, D. Calvin Campbell, Marie Charrière, Masahiro Chigira, John J. Clague, John Coggan, Giovanni B. Crosta, Tim Davies, Marc-Henri Derron, Mark Diederichs, Erik Eberhardt, Carlo Esposito, Robin Fell, Paolo Frattini, Corey R. Froese, Monica Ghirotti, Valentin Gischig, James S. Griffiths, Stephen R. Hencher, Reginald L. Hermanns, Kris Holm, Seyyedmahdi Hosseyni, Niels Hovius, Christian Huggel, Florian Humair, Oldrich Hungr, D. Jean Hutchinson, Michel Jaboyedoff, Matthias Jakob, Julien Jakubowski, Randall W. Jibson, Katherine S. Kalenchuk, Nikolay Khabarov, Oliver Korup, Luca Lenti, Serge Leroueil, Simon Loew, Oddvar Longva, Patrick MacGregor, Andrew W. Malone, Salvatore Martino, Scott McDougall, Mika McKinnon, Mauri McSaveney, Patrick Meunier, Dennis Moore, Jeffrey R. Moore, David C. Mosher, Michael Obersteiner, Lucio Olivares, Thierry Oppikofer, Luca Pagano, Massimo Pecci, Andrea Pedrazzini, David Petley, Luciano Picarelli, David J.W. Piper, John Psutka, Nicholas J. Roberts, Gabriele Scarascia Mugnozza, David Stapledon, Douglas Stead, Richard E. Thomson, Paolo Tommasi, J. Kenneth Torrance, Nobuyuki Torii, Gianfranco Urciuoli, Gonghui Wang, Christopher F. Waythomas, Malcolm Whitworth, Heike Willenberg, Xiyong Wu
- Edited by John J. Clague, Simon Fraser University, British Columbia, Douglas Stead, Simon Fraser University, British Columbia
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- Landslides
- Published online:
- 05 May 2013
- Print publication:
- 23 August 2012, pp vii-x
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10 - Tsunami hazard assessment related to slope failures in coastal waters
- Edited by John J. Clague, Simon Fraser University, British Columbia, Douglas Stead, Simon Fraser University, British Columbia
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- Landslides
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- 05 May 2013
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- 23 August 2012, pp 108-120
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Summary
Abstract Although subaerial and subaqueous landslides have been responsible for many tsunamis in high-relief coastal areas around the world, routine assessments of these hazards are rarely undertaken. Assessment must draw on the expertise of geoscientists, engineers, and hydrodynamicists, and requires analyses of both the landslide and the resulting waves. Landslide tsunami assessments aim to determine:
occurrences of past events
likelihood of future occurrences
magnitudes of past events
locations experiencing greatest impact
conditions and triggers that led to failure
wave characteristics and coastal run-up.
Key assessment considerations include the geologic evidence of past failures, both subaerial and subaqueous, and the written or oral history of past events. These can aid in determining whether further assessment studies are warranted. The general paucity of observations of past events, however, makes empirical assessment difficult. As a consequence, physical and numerical modeling are critical tools in characterizing the phenomena. Because modern numerical models are fast to run and relatively inexpensive, they are now widely used for specific case studies. Much can be learned before failures occur in areas prone to tsunamigenic landslides. Hydrodynamic modeling, combined with geologic and geotechnical evidence, can be used to assess the tsunamigenic potential of landslides. Although definitive estimates of the frequency of occurrence and magnitude of tsunamigenic events are difficult to make, analyses can place valuable constraints on the siting and design of coastal facilities.
Electronic Surveillance for Infectious Disease Trend Analysis following a Quality Improvement Intervention
- Kari E. Peterson, Donna M. Hacek, Ari Robicsek, Richard B. Thomson, Jr, Lance R. Peterson
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 33 / Issue 8 / August 2012
- Published online by Cambridge University Press:
- 02 January 2015, pp. 790-795
- Print publication:
- August 2012
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Objective.
Interventions for reducing methicillin-resistant Staphylococcus aureus (MRSA) healthcare-associated disease require outcome assessment; this is typically done by manual chart review to determine infection, which can be labor intensive. The purpose of this study was to validate electronic tools for MRSA healthcare-associated infection (HAI) trending that can replace manual medical record review.
Design and Setting.This was an observational study comparing manual medical record review with 3 electronic methods: raw culture data from the laboratory information system (LIS) in use by our healthcare organization, LIS data combined with admission-discharge-transfer (ADT) data to determine which cultures were healthcare associated (LIS + ADT), and the CareFusion MedMined Nosocomial Infection Marker (NIM). Each method was used for the same 7-year period from August 2003 through July 2010.
Patients.The data set was from a 3-hospital organization covering 342,492 admissions.
Results.Correlation coefficients for raw LIS, LIS + ADT, and NIM were 0.976, 0.957, and 0.953, respectively, when assessed on an annual basis. Quarterly performance for disease trending was also good, with R2 values exceeding 0.7 for all methods.
Conclusions.The electronic tools accurately identified trends in MRSA HAI incidence density when all infections were combined as quarterly or annual data; the performance is excellent when annual assessment is done. These electronic surveillance systems can significantly reduce (93% [in-house-developed program] to more than 99.9999% [commercially available systems]) the personnel resources needed to monitor the impact of a disease control program.
Contributors
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- By Maged Argalious, Craig Beattie, Bruce Biccard, John Carlisle, Rod T. A. Chalmers, Michael F. M. James, Ivan A. Joubert, Danny McGee, Carl Moores, Gary A. Morrison, Charles Morton, Alastair F. Nimmo, Suzy O' Neill, Chris P. Snowden, Mark D. Stoneham, Michael Swart, Richard Telford, Alastair J. Thomson, John A. Wilson
- Edited by Carl Moores, Alastair F. Nimmo
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- Book:
- Core Topics in Vascular Anaesthesia
- Published online:
- 05 July 2012
- Print publication:
- 07 June 2012, pp vi-vi
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Electronic Prediction Rules for Methicillin-Resistant Staphylococcus aureus Colonization
- Ari Robicsek, Jennifer L. Beaumont, Marc-Oliver Wright, Richard B. Thomson, Jr, Karen L. Kaul, Lance R. Peterson
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- Journal:
- Infection Control & Hospital Epidemiology / Volume 32 / Issue 1 / January 2011
- Published online by Cambridge University Press:
- 02 January 2015, pp. 9-19
- Print publication:
- January 2011
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Background.
Considerable hospital resources are dedicated to minimizing the number of methicillin-resistant Staphylococcus aureus (MRSA) infections. One tool that is commonly used to achieve this goal is surveillance for MRSA colonization. This process is costly, and false-positive test results lead to isolation of individuals who do not carry MRSA. The performance of this technique would improve if patients who are at high risk of colonization could be readily targeted.
Methods.Five MRSA colonization prediction rules of varying complexity were derived in a population of 23,314 patients who were consecutively admitted to a US hospital and tested for colonization. Rules incorporated only prospectively collected, structured electronic data found in a patient's record within 1 day of hospital admission. These rules were tested in a validation cohort of 26,650 patients who were admitted to 2 other hospitals.
Results.The prevalence of MRSA at hospital admission was 2.2% and 4.0% in the derivation and validation cohorts, respectively. Multivariable modeling identified predictors of MRSA colonization among demographic, admission-related, pharmacologic, laboratory, physiologic, and historical variables. Five prediction rules varied in their performance, but each could be used to identify the 30% of patients who accounted for greater than 60% of all cases of MRSA colonization and approximately 70% of all MRSA-associated patient-days. Most rules could also identify the 20% of patients with a greater than 8% chance of colonization and the 40% of patients among whom colonization prevalence was 2% or less.
Conclusions.We report electronic prediction rules that can fully automate triage of patients for MRSA-related hospital admission testing and that offer significant improvements on previously reported rules. The efficiencies introduced may result in savings to infection control programs with little sacrifice in effectiveness.