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Characterisation of age and polarity at onset in bipolar disorder
- Janos L. Kalman, Loes M. Olde Loohuis, Annabel Vreeker, Andrew McQuillin, Eli A. Stahl, Douglas Ruderfer, Maria Grigoroiu-Serbanescu, Georgia Panagiotaropoulou, Stephan Ripke, Tim B. Bigdeli, Frederike Stein, Tina Meller, Susanne Meinert, Helena Pelin, Fabian Streit, Sergi Papiol, Mark J. Adams, Rolf Adolfsson, Kristina Adorjan, Ingrid Agartz, Sofie R. Aminoff, Heike Anderson-Schmidt, Ole A. Andreassen, Raffaella Ardau, Jean-Michel Aubry, Ceylan Balaban, Nicholas Bass, Bernhard T. Baune, Frank Bellivier, Antoni Benabarre, Susanne Bengesser, Wade H Berrettini, Marco P. Boks, Evelyn J. Bromet, Katharina Brosch, Monika Budde, William Byerley, Pablo Cervantes, Catina Chillotti, Sven Cichon, Scott R. Clark, Ashley L. Comes, Aiden Corvin, William Coryell, Nick Craddock, David W. Craig, Paul E. Croarkin, Cristiana Cruceanu, Piotr M. Czerski, Nina Dalkner, Udo Dannlowski, Franziska Degenhardt, Maria Del Zompo, J. Raymond DePaulo, Srdjan Djurovic, Howard J. Edenberg, Mariam Al Eissa, Torbjørn Elvsåshagen, Bruno Etain, Ayman H. Fanous, Frederike Fellendorf, Alessia Fiorentino, Andreas J. Forstner, Mark A. Frye, Janice M. Fullerton, Katrin Gade, Julie Garnham, Elliot Gershon, Michael Gill, Fernando S. Goes, Katherine Gordon-Smith, Paul Grof, Jose Guzman-Parra, Tim Hahn, Roland Hasler, Maria Heilbronner, Urs Heilbronner, Stephane Jamain, Esther Jimenez, Ian Jones, Lisa Jones, Lina Jonsson, Rene S. Kahn, John R. Kelsoe, James L. Kennedy, Tilo Kircher, George Kirov, Sarah Kittel-Schneider, Farah Klöhn-Saghatolislam, James A. Knowles, Thorsten M. Kranz, Trine Vik Lagerberg, Mikael Landen, William B. Lawson, Marion Leboyer, Qingqin S. Li, Mario Maj, Dolores Malaspina, Mirko Manchia, Fermin Mayoral, Susan L. McElroy, Melvin G. McInnis, Andrew M. McIntosh, Helena Medeiros, Ingrid Melle, Vihra Milanova, Philip B. Mitchell, Palmiero Monteleone, Alessio Maria Monteleone, Markus M. Nöthen, Tomas Novak, John I. Nurnberger, Niamh O'Brien, Kevin S. O'Connell, Claire O'Donovan, Michael C. O'Donovan, Nils Opel, Abigail Ortiz, Michael J. Owen, Erik Pålsson, Carlos Pato, Michele T. Pato, Joanna Pawlak, Julia-Katharina Pfarr, Claudia Pisanu, James B. Potash, Mark H Rapaport, Daniela Reich-Erkelenz, Andreas Reif, Eva Reininghaus, Jonathan Repple, Hélène Richard-Lepouriel, Marcella Rietschel, Kai Ringwald, Gloria Roberts, Guy Rouleau, Sabrina Schaupp, William A Scheftner, Simon Schmitt, Peter R. Schofield, K. Oliver Schubert, Eva C. Schulte, Barbara Schweizer, Fanny Senner, Giovanni Severino, Sally Sharp, Claire Slaney, Olav B. Smeland, Janet L. Sobell, Alessio Squassina, Pavla Stopkova, John Strauss, Alfonso Tortorella, Gustavo Turecki, Joanna Twarowska-Hauser, Marin Veldic, Eduard Vieta, John B. Vincent, Wei Xu, Clement C. Zai, Peter P. Zandi, Psychiatric Genomics Consortium (PGC) Bipolar Disorder Working Group, International Consortium on Lithium Genetics (ConLiGen), Colombia-US Cross Disorder Collaboration in Psychiatric Genetics, Arianna Di Florio, Jordan W. Smoller, Joanna M. Biernacka, Francis J. McMahon, Martin Alda, Bertram Müller-Myhsok, Nikolaos Koutsouleris, Peter Falkai, Nelson B. Freimer, Till F.M. Andlauer, Thomas G. Schulze, Roel A. Ophoff
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- Journal:
- The British Journal of Psychiatry / Volume 219 / Issue 6 / December 2021
- Published online by Cambridge University Press:
- 25 August 2021, pp. 659-669
- Print publication:
- December 2021
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Background
Studying phenotypic and genetic characteristics of age at onset (AAO) and polarity at onset (PAO) in bipolar disorder can provide new insights into disease pathology and facilitate the development of screening tools.
AimsTo examine the genetic architecture of AAO and PAO and their association with bipolar disorder disease characteristics.
MethodGenome-wide association studies (GWASs) and polygenic score (PGS) analyses of AAO (n = 12 977) and PAO (n = 6773) were conducted in patients with bipolar disorder from 34 cohorts and a replication sample (n = 2237). The association of onset with disease characteristics was investigated in two of these cohorts.
ResultsEarlier AAO was associated with a higher probability of psychotic symptoms, suicidality, lower educational attainment, not living together and fewer episodes. Depressive onset correlated with suicidality and manic onset correlated with delusions and manic episodes. Systematic differences in AAO between cohorts and continents of origin were observed. This was also reflected in single-nucleotide variant-based heritability estimates, with higher heritabilities for stricter onset definitions. Increased PGS for autism spectrum disorder (β = −0.34 years, s.e. = 0.08), major depression (β = −0.34 years, s.e. = 0.08), schizophrenia (β = −0.39 years, s.e. = 0.08), and educational attainment (β = −0.31 years, s.e. = 0.08) were associated with an earlier AAO. The AAO GWAS identified one significant locus, but this finding did not replicate. Neither GWAS nor PGS analyses yielded significant associations with PAO.
ConclusionsAAO and PAO are associated with indicators of bipolar disorder severity. Individuals with an earlier onset show an increased polygenic liability for a broad spectrum of psychiatric traits. Systematic differences in AAO across cohorts, continents and phenotype definitions introduce significant heterogeneity, affecting analyses.
19 - Legislated collaboration in a conservation conflict: a case study of the Quincy Library Group in California, USA
- from Part III - Approaches to managing conflicts
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- By R. J. Gutiéerrez, University of Minnesota, Antony S. Cheng, Colorado State University, Dennis R. Becker, University of Minnesota, Scott Cashen, California, David Ganz, United States Aid for International Development, John Gunn, Spatial Informatics Group, Michael Liquori, Soundwatershed, Amy Merrill, Stillwater Sciences, D. S. Saah, Spatial Informatics Group, William Price, Pinchot Institute for Conservation
- Edited by Stephen M. Redpath, University of Aberdeen, R. J. Gutiérrez, University of Minnesota, Kevin A. Wood, Bournemouth University, Juliette C. Young, NERC Centre for Ecology and Hydrology, UK
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- Book:
- Conflicts in Conservation
- Published online:
- 05 May 2015
- Print publication:
- 07 May 2015, pp 271-286
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Summary
Nearly 258 million ha (28%) of the United States is publicly owned land that is managed by federal government agencies. For example, the US Department of Agriculture's Forest Service (USFS) manages over 77 million ha of national forests and grasslands for the benefit of the American public. Given its legal directive to manage multiple uses, it is not surprising that conflicts arise among stakeholders over how this land should be used (Lansky, 1992). The USFS has much discretion in how land is managed, yet must often balance conflicting values of public use and benefit (Nie, 2004). As national priorities, social preferences and public awareness of national forest goods, services and values have changed over time, USFS managers have faced increased pressure to balance consumptive uses with the need for environmental protection. Competing stakeholder demands coupled with increased environmental risks (wildfires, tree diseases and insect epidemics) have resulted in an escalating conservation conflict that is manifested in administrative appeals, lawsuits and a growing distrust of the agency.
Over time, the USFS has embraced new directions and management paradigms to reduce conflict. Some of these have been ecosystem management, adaptive management and now collaborative management (e.g. Holling, 1978; Maser, 1988; Franklin, 1992; Boyce and Haney, 1997; Wondolleck and Yaffee, 2000; Brown et al., 2004). These approaches reflect changing societal values, political pressures and new scientific information.
A persistent conflict has been the logging of trees in national forests and related impacts on forest ecosystems (Lansky, 1992). The USFS’ timber sale programme has supported jobs and community stability through economic development. Logging has also been a mechanism to reduce the risk of wildfire by reducing tree density (fuel for fires) and vertical stand diversity (‘ladder’ fuels; North et al., 2009). However, logging can also negatively affect forest integrity, watershed quality, wildlife, aesthetic and spiritual values of forests (Satterfield, 2002; North et al., 2009).
Contributors
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- By Aaron Ben-Ze’ev, F. H. Buckley, Mina Cikara, David Combs, N. T. Feather, Kurt Feyaerts, Agneta H. Fischer, Susan T. Fiske, Charles Hoogland, Giselinde Kuipers, Colin Wayne Leach, Antony S. R. Manstead, Bert Oben, Diederik Oostdijk, Jaap W. Ouwerkerk, John Portmann, Caitlin A. J. Powell, Mark Rotteveel, D. Ryan Schurtz, Elise C. Seip, Richard H. Smith, Russell Spears, Jill M. Sundie, Stephen M. Thielke, Niels van de Ven, Wilco W. van Dijk, Lotte F. van Dillen
- Edited by Wilco W. van Dijk, Universiteit Leiden, Jaap W. Ouwerkerk, Vrije Universiteit, Amsterdam
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- Book:
- Schadenfreude
- Published online:
- 05 August 2014
- Print publication:
- 24 July 2014, pp x-xii
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Australia's Role in Gravitational Wave Detection
- John S. Jacob, Pablo Barriga, David G. Blair, Aidan Brooks, Ron Burman, Raymond Burston, Lee Chan, XiuTing Chan, Eu-Jeen Chin, Jong Chow, David Coward, Benedict Cusack, Glen de Vine, Jerome Degallaix, Jean-Charles Dumas, Angus Faulkner, Florin Garoi, Slawomir Gras, Malcolm Gray, Murray Hamilton, Matthew Herne, C. Hollitt, David Hosken, Eric Howell, Li Ju, T. Kelly, Ben Lee, Chuen Ying Lee, Kah Tho Lee, Antony Lun, David McClelland, Kirk McKenzie, C. Mow-Lowry, Damien Mudge, Jesper Munch, Darren Paget, Sascha Schediwy, Susan Scott, Antony Searle, Ben Sheard, Bram Slagmolen, Peter Veitch, John Winterflood, Andrew Woolley, Zewu Yan, Chunnong Zhao
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- Journal:
- Publications of the Astronomical Society of Australia / Volume 20 / Issue 3 / 2003
- Published online by Cambridge University Press:
- 05 March 2013, pp. 223-241
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An enormous effort is underway worldwide to attempt to detect gravitational waves. If successful, this will open a new frontier in astronomy. An essential portion of this effort is being carried out in Australia by the Australian Consortium for Interferometric Gravitational Astronomy (ACIGA), with research teams working at the Australia National University, University of Western Australia, and University of Adelaide involving scientists and students representing many more institutions and nations. ACIGA is developing ultrastable high-power continuous-wave lasers for the next generation interferometric gravity wave detectors; researching the problems associated with high optical power in resonant cavities; opening frontiers in advanced interferometry configurations, quantum optics, and signal extraction; and is the world's leader in high-performance vibration isolation and suspension design. ACIGA has also been active in theoretical research and modelling of potential astronomical gravitational wave sources, and in developing data analysis detection algorithms. ACIGA has opened a research facility north of Perth, Western Australia, which will be the culmination of these efforts. This paper briefly reviews ACIGA's research activities and the prospects for gravitational wave astronomy in the southern hemisphere.
Contributors
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- By Antony R. Absalom, Lorenz Breuer, Christoph S. Burkhart, Rowan M. Burnstein, Ian Calder, Jonathan P. Coles, Amanda Cox, Marek Czosnyka, Armagan Dagal, Judith Dinsmore, Derek Duane, Kristin Engelhard, Ari Ercole, Rik Fox, Sabrina G. Galloway, Arnab Ghosh, Arun K. Gupta, Nicholas Hirsch, Robin Howard, Peter Hutchinson, Nicole C. Keong, Martin Köhrmann, Arthur M. Lam, Andrea Lavinio, Brian P. Lemkuil, Luca Longhi, Craig D. McClain, Robert Macfarlane, Basil F. Matta, Stephan A. Mayer, David K. Menon, Andrew W. Michell, Dick Moberg, Paul G. Murphy, Clara Poon, Amit Prakash, Frank Rasulo, Fred Rincon, Stefan Schwab, Martin Smith, Sulpicio G. Soriano, Luzius A. Steiner, Nino Stocchetti, Stephan P. Strebel, Jane Sturgess, Magnus Teig, Tonny Veenith, Christian Werner, Christian Zweifel
- Edited by Basil F. Matta, David K. Menon, Martin Smith
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- Book:
- Core Topics in Neuroanaesthesia and Neurointensive Care
- Published online:
- 05 December 2011
- Print publication:
- 13 October 2011, pp vii-x
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Contributors
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- By Marie-Germaine Bousser, Joseph P. Broderick, Ken Butcher, Louis R. Caplan, J. Ricardo Carhuapoma, José Castillo, Michael Chen, Rush H. Chewning, Frederick Colbourne, Isabelle Crassard, Antoni Dávalos, Stephen M. Davis, Lisa M. DeAngelis, Matthew L. Flaherty, Steven M. Greenberg, Daniel F. Hanley, Ameer E. Hassan, Julian T. Hoff, Andreas F. Hottinger, Hagen B. Huttner, Carlos S. Kase, Richard F. Keep, Crystal MacLellan, Stephan A. Mayer, A. David Mendelow, J. P. Mohr, Kieran P. Murphy, Neeraj S. Naval, Paul A. Nyquist, James Peeling, Adnan I. Qureshi, Manuel Rodriguez-Yáñez, Christian Stapf, Thorsten Steiner, Stanley Tuhrim, Kenneth R. Wagner, Daniel Woo, Guohua Xi, Haralabos Zacharatos, Wendy C. Ziai, Mario Zuccarello
- Edited by J. Ricardo Carhuapoma, Stephan A. Mayer, Columbia University, New York, Daniel F. Hanley
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- Intracerebral Hemorrhage
- Published online:
- 04 May 2010
- Print publication:
- 12 November 2009, pp ix-xi
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Psychiatric symptoms, personality and ways of coping in chronic fatigue syndrome
- Antony A. Blakely, Rick C. Howard, Rowena M. Sosich, J. Campbell Murdoch, David B. Menkes, George F. S. Spears
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- Journal:
- Psychological Medicine / Volume 21 / Issue 2 / May 1991
- Published online by Cambridge University Press:
- 09 July 2009, pp. 347-362
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This study aimed to investigate the psychological characteristics of chronic fatigue syndrome (CFS: Holmes et al. 1988). A battery of psychometric instruments comprising the General Health Questionnaire (GHQ), the Beck Depression Inventory (BDI), the Minnesota Multiphasic Personality Inventory (MMPI) and the Lazarus Ways of Coping (WoC) inventory, was administered to a sample of clinically-defined CFS sufferers (N = 58), to a comparison group of chronic pain (CP) patients (N = 81) and to a group of healthy controls matched for sex and age with the CFS sample (N = 104). Considerable overlap was found between CFS and CP patients at the level of both physical and psychological symptoms. This raises the possibility that CFS sufferers are a sub-population of CP patients. However, while there was some commonality between CFS and CP patients in terms of personality traits, particularly the MMPI ‘neurotic triad’ (hypochondriasis, depression and hysteria), CFS patients showed more deviant personality traits reflecting raised levels on the first MMPI factor, emotionality. Moreover, results were not consistent with the raised emotionality being a reaction to the illness, but rather were consistent with the hypothesis that emotionality is a predisposing factor for CFS. The majority of CFS patients fell within four personality types, each characterized by the two highest MMPI scale scores. One type (N = 20) reported a lack of psychological symptoms or emotional disturbance contrary to the overall trend for the CFS sample. This group conformed to the ICD-10 classification of neurasthenia.
Signs of asphyxia at birth and risk of schizophrenia: Population-based case–control study
- Christina Dalman, Hollie V. Thomas, Antony S. David, Johan Gentz, Glyn Lewis, Peter Allebeck
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- Journal:
- The British Journal of Psychiatry / Volume 179 / Issue 5 / November 2001
- Published online by Cambridge University Press:
- 02 January 2018, pp. 403-408
- Print publication:
- November 2001
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Background
Previous research has found an association between obstetric complications and schizophrenia, but in many studies the sample size was limited, and no assessment of specific exposures was possible.
AimsTo assess the role of different complications, and in particular to distinguish between disordered foetal development and hypoxia at birth.
MethodFrom the Stockholm County In-Patient Register and community registers, we identified 524 cases of schizophrenia and 1043 controls, matched for age, gender, hospital and parish of birth. Data on obstetric complications were obtained from birth records.
ResultsThere was a strong association between signs of asphyxia at birth and schizophrenia (OR 4.4; 95% C11.9–10.3) after adjustment for other obstetric complications, maternal history of psychotic illness and social class.
ConclusionsSigns of asphyxia at birth are associated with an increased risk of schizophrenia in adults.