2 results
Childhood trauma moderates schizotypy-related brain morphology: analyses of 1182 healthy individuals from the ENIGMA schizotypy working group
- Yann Quidé, Oliver J. Watkeys, Emiliana Tonini, Dominik Grotegerd, Udo Dannlowski, Igor Nenadić, Tilo Kircher, Axel Krug, Tim Hahn, Susanne Meinert, Janik Goltermann, Marius Gruber, Frederike Stein, Katharina Brosch, Adrian Wroblewski, Florian Thomas-Odenthal, Paula Usemann, Benjamin Straube, Nina Alexander, Elisabeth J. Leehr, Jochen Bauer, Nils R. Winter, Lukas Fisch, Katharina Dohm, Wulf Rössler, Lukasz Smigielski, Pamela DeRosse, Ashley Moyett, Josselin Houenou, Marion Leboyer, James Gilleen, Sophia I. Thomopoulos, Paul M. Thompson, André Aleman, Gemma Modinos, Melissa J. Green
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- Journal:
- Psychological Medicine / Volume 54 / Issue 6 / April 2024
- Published online by Cambridge University Press:
- 20 October 2023, pp. 1215-1227
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- Article
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Background
Schizotypy represents an index of psychosis-proneness in the general population, often associated with childhood trauma exposure. Both schizotypy and childhood trauma are linked to structural brain alterations, and it is possible that trauma exposure moderates the extent of brain morphological differences associated with schizotypy.
MethodsWe addressed this question using data from a total of 1182 healthy adults (age range: 18–65 years old, 647 females/535 males), pooled from nine sites worldwide, contributing to the Enhancing NeuroImaging Genetics through Meta-Analysis (ENIGMA) Schizotypy working group. All participants completed both the Schizotypal Personality Questionnaire Brief version (SPQ-B), and the Childhood Trauma Questionnaire (CTQ), and underwent a 3D T1-weighted brain MRI scan from which regional indices of subcortical gray matter volume and cortical thickness were determined.
ResultsA series of multiple linear regressions revealed that differences in cortical thickness in four regions-of-interest were significantly associated with interactions between schizotypy and trauma; subsequent moderation analyses indicated that increasing levels of schizotypy were associated with thicker left caudal anterior cingulate gyrus, right middle temporal gyrus and insula, and thinner left caudal middle frontal gyrus, in people exposed to higher (but not low or average) levels of childhood trauma. This was found in the context of morphological changes directly associated with increasing levels of schizotypy or increasing levels of childhood trauma exposure.
ConclusionsThese results suggest that alterations in brain regions critical for higher cognitive and integrative processes that are associated with schizotypy may be enhanced in individuals exposed to high levels of trauma.
8 - Planetary structural mapping
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- By Kenneth L. Tanaka, U.S. Geological Survey, Flagstaff, Robert Anderson, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, James M. Dohm, Department of Hydrology and Water Resources, University of Arizona, Tucson, Vicki L. Hansen, Department of Geological Sciences, University of Minnesota Duluth, George E. McGill, University of Massachusetts, Amherst, Robert T. Pappalardo, Jet Propulsion Laboratory, California Institute of Technology, Pasadena, Richard A. Schultz, Geomechanics – Rock Fracture Group, Department of Geological Sciences and Engineering, University of Nevada, Reno, Thomas R. Watters, Center for Earth and Planetary Studies, National Air and Space Museum, Smithsonian Institution, Washington, DC
- Edited by Thomas R. Watters, Smithsonian Institution, Washington DC, Richard A. Schultz, University of Nevada, Reno
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- Book:
- Planetary Tectonics
- Published online:
- 30 March 2010
- Print publication:
- 17 December 2009, pp 351-396
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- Chapter
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Summary
Summary
As on Earth, other solid-surfaced planetary bodies in the solar system display landforms produced by tectonic activity, such as faults, folds, and fractures. These features are resolved in spacecraft observations directly or with techniques that extract topographic information from a diverse suite of data types, including radar backscatter and altimetry, visible and near-infrared images, and laser altimetry. Each dataset and technique has its strengths and limitations that govern how to optimally utilize and properly interpret the data and what sizes and aspects of features can be recognized. The ability to identify, discriminate, and map tectonic features also depends on the uniqueness of their form, on the morphologic complexity of the terrain in which the structures occur, and on obscuration of the features by erosion and burial processes. Geologic mapping of tectonic structures is valuable for interpretation of the surface strains and of the geologic histories associated with their formation, leading to possible clues about: (1) the types or sources of stress related to their formation, (2) the mechanical properties of the materials in which they formed, and (3) the evolution of the body's surface and interior where timing relationships can be determined. Formal mapping of tectonic structures has been performed and/or is in progress for Earth's Moon, the planets Mars, Mercury, and Venus, and the satellites of Jupiter (Callisto, Ganymede, Europa, and Io).