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Clinical predictors of kynurenine pathway aberrations in schizophrenia and bipolar disorder
- K. Skorobogatov, M. Leboyer, M. Foiselle, M. Morrens, L. De Picker
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- Journal:
- European Psychiatry / Volume 65 / Issue S1 / June 2022
- Published online by Cambridge University Press:
- 01 September 2022, p. S365
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- Article
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Introduction
Schizophrenia and bipolar disorder are severe mental illnesses that are known to have a considerable overlap in underlying pathophysiological mechanisms. More specifically, disturbances in the kynurenine pathway have been hypothesized as processes bridging altered immune responses and clinical manifestations of these illnesses.
ObjectivesThe aim of this study was to investigate the abnormalities in serum kynurenine metabolites in schizophrenic and bipolar patients and the impact of clinical factors.
MethodsFour patient groups were included in the current study: 1) Acute bipolar inpatients (n=205); 2) stable bipolar outpatients (n=116); 3) acute schizophrenia inpatients (n=111) and 4) stable schizophrenia outpatients (n=75); and one healthy control group (n=185). Clinical symptoms were established using symptom severity scales. The quantitative determination of serum kynurenine metabolites was performed using LC-MS/MS. General linear model and multivariate linear regression analyses were used to perform the statistical analysis with JMP Pro 15.
ResultsIn line with previous research, the results indicate that serum kynurenine metabolites are disturbed in schizophrenic and bipolar patients compared to healthy controls. Whereas no differences were observed between schizophrenia and bipolar disorder, illness state and duration of illness clearly impacted kynurenine metabolite levels. Acutely ill patients had significantly lower levels compared to stable patients, which seemed to be driven by psychotic symptoms.
ConclusionsTo conclude, the results confirm the involvement of the kynurenine pathway in the pathophysiology of schizophrenia and bipolar disorder by lowered peripheral kynurenine metabolite level. In addition, an important role of acute psychotic symptoms and longer illness duration on these metabolite aberrances is demonstrated.
DisclosureNo significant relationships.
In Lieu of Birthday Greetings
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- By B. J. Birch, Mathematical Institute, 24-29 St Giles', Oxford, OX1 3LB, UK, Jean-Louis Colliot-Thélène, C.N.R.S., U.M.R. 8628, Mathématiques, Bâtiment 425, Université de Paris-Sud, F-91405 Orsay, France, G. K. Sankaran, Department of Mathematical Sciences, University of Bath, Bath BA2 7AY, England, Miles Reid, Math Inst., Univ. of Warwick, Coventry CV4 7AL, England, Alexei Skorobogatov, Department of Mathematics, Imperial College London, South Kensington Campus, London SW7 2AZ, England
- Edited by Miles Reid, University of Warwick, Alexei Skorobogatov, Imperial College of Science, Technology and Medicine, London
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- Book:
- Number Theory and Algebraic Geometry
- Published online:
- 04 August 2010
- Print publication:
- 26 January 2004, pp 1-22
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Summary
This is a volume of papers in honour of Peter Swinnerton-Dyer's 75th birthday; we very much regret that it appears a few months late owing to the usual kind of publication delays. This preface contains four sections of reminiscences, attempting the impossible task of outlining Peter's many-sided contributions to human culture. Section 5 is the editor's summary of the 12 papers making up the book, and the preface ends with a bibliographical section of Peter's papers to date.
Peter's first sixty years in Mathematics by Bryan Birch
Peter Swinnerton-Dyer wrote his first paper as a young schoolboy just 60 years ago, under the abbreviated name P. S. Dyer; in it, he gave a new parametric solution for x4 + y4 = z4 + t4. It is very appropriate that his first paper was on the arithmetic of surfaces, the theme that recurs most often in his mathematical work; indeed, for several years he was almost the only person writing substantial papers on the subject; and he is still writing papers about the arithmetic of surfaces sixty years later. Peter went straight from school to Trinity College (National Service had not quite been introduced); after his BA, he began research as an analyst, advised by J E Littlewood.