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State of the art of participatory and user-led research in mental health in Brazil: A scoping review
- Ana Carolina Florence, Mateus Bocalini, Daniela Cabrini, Rita Tanzi, Melissa Funaro, Gerald Jordan, Larry Davidson, Robert Drake, Cristian Montenegro, Silvio Yasui
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- Journal:
- Cambridge Prisms: Global Mental Health / Volume 10 / 2023
- Published online by Cambridge University Press:
- 05 April 2023, e21
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Participatory research denotes the engagement and meaningful involvement of the community of interest across multiple stages of investigation, from design to data collection, analysis, and publication. Traditionally, people with first-hand experience of psychiatric diagnoses, service users, and those living with a psychosocial disability have been seen objects rather than agents of research and knowledge production, despite the ethical and practical benefits of their involvement. The state of the art of knowledge about participatory research in mental health Brazil is poorly understood outside of its local context. The purpose of this article was to conduct a scoping review of participatory and user-led research in mental health in Brazil. We identified 20 articles that met eligibility criteria. Participation in research was not treated as separate from participation in shaping mental health policy, driving care, or the broader right to fully participate in societal life and enjoy social and civil rights. Studies identified several obstacles to full participation, including the biomedical model, primacy of academic and scientific knowledge, and systemic barriers. Our extraction, charting, and synthesis yielded four themes: power, knowledge, autonomy, and empowerment. Participation in this context must address the intersecting vulnerabilities experienced by those who are both Brazilian and labeled as having a mental illness. Participatory research and Global South leadership must foreground local epistemologies that can contribute to the global debate about participation and mental health research.
Introduction to supported employment
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- Robert E. Drake
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- Epidemiology and Psychiatric Sciences / Volume 29 / 2020
- Published online by Cambridge University Press:
- 18 November 2020, e185
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Employment is a critical mental health intervention
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- Robert E. Drake, Michael A. Wallach
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- Epidemiology and Psychiatric Sciences / Volume 29 / 2020
- Published online by Cambridge University Press:
- 05 November 2020, e178
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Abstract employment is critically important in mental health care. Unemployment worsens mental health and gaining employment can improve mental health, even for people with the most serious mental illnesses. In this editorial, we argue for a new treatment paradigm in mental health that emphasises employment, because supported employment is an evidence-based intervention that can help the majority of people with mental health disability to succeed in integrated, competitive employment. Unlike most mental health treatments, employment engenders self-reliance and leads to other valued outcomes, including self-confidence, the respect of others, personal income and community integration. It is not only an effective short-term treatment but also one of the only interventions that lessen dependence on the mental health system over time.
National levels of human development and number of mental hospital beds
- Justin Metcalfe, Robert Drake
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- Journal:
- Epidemiology and Psychiatric Sciences / Volume 29 / 2020
- Published online by Cambridge University Press:
- 08 September 2020, e167
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Aims
The number of mental hospital beds per population varies widely across countries, and the reasons for this variation are not fully understood. Given that differences in disease prevalence do not explain variation in inpatient mental health care availability, we examined the relationship between mental hospital beds and national income, education and longevity as measured by the Human Development Index (HDI).
MethodsWe used an international dataset of social, economic and structural measures to conduct a mixed-effects longitudinal regression of predictors of the number of mental hospital beds per 100 000 in the overall population for 86 countries for years 2005–2015.
ResultsOur initial dataset contained 1881 observations consisting of 11 years of potential measurements across 171 countries. After eliminations based on missing data and subsequent imputation, the dataset for the final regression model included 946 observations over 86 countries. The primary predictors of a country's number of mental hospital beds were year, HDI and GINI coefficient, the latter being a measure of income disparity. Holding all other factors constant, the number of beds decreased 8% per year, reflecting the ongoing international trend of deinstitutionalisation. As hypothesised, higher HDI predicted more mental hospital beds. Every 0.1 increase in HDI (0–1.0) was associated with a 126% increase in the number of hospital beds at the sample's mean GINI index score of 38 (0–100). However, a strong interaction between HDI and the GINI coefficient indicated that a high level of income disparity attenuated the positive association between HDI and mental hospital beds. At a GINI index score of 48, every 0.1 increase in HDI was associated with a 71% increase in the number of hospital beds.
ConclusionsAs countries reduce the number of hospital beds over time, higher levels of economic disparity are associated with a reduction in the strength of the association between national prosperity and investment in mental hospitals. As power becomes increasingly concentrated, perhaps those with the least are more easily forgotten.
Mental health technology tools: two alternative approaches
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- Robert E. Drake
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- Journal:
- Epidemiology and Psychiatric Sciences / Volume 29 / 2020
- Published online by Cambridge University Press:
- 03 February 2020, e99
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Changes in smoking status, mental state and plasma clozapine concentration: retrospective cohort evaluation
- Inti Qurashi, Paul Stephenson, Chitra Nagaraj, Simon Chu, Richard Drake, Lewis Couchman, Robert Flanagan
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- Journal:
- BJPsych Bulletin / Volume 43 / Issue 6 / December 2019
- Published online by Cambridge University Press:
- 08 August 2019, pp. 271-274
- Print publication:
- December 2019
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Aims and method
To investigate the percentage of patients who commenced smoking after transferring out of a non-smoking forensic psychiatric unit, the corresponding clozapine dose adjustments, the effects on plasma clozapine/norclozapine concentrations and observed changes in mental state. We reviewed the notes and plasma clozapine/norclozapine concentrations of 46 patients transferred to medium secure units between July 2008 and December 2013.
ResultsThirty-five patients commenced smoking. Their median clozapine dose was increased by 50 mg/d. In the non-smokers, the median clozapine dose remained unchanged. Plasma clozapine/norclozapine concentrations were significantly reduced in smokers despite dosage adjustment. Eighteen patients experienced deterioration in mental state after transfer; almost all these patients were smokers.
Clinical implicationsApproximately three-quarters of patients who were non-smokers by virtue of being in a secure non-smoking environment commenced smoking after transfer. Monitoring of clozapine serum levels and assessment of mental state in the immediate period after a change in smoking status is indicated.
Enhancing return to work or school after a first episode of schizophrenia: the UCLA RCT of Individual Placement and Support and Workplace Fundamentals Module training
- Keith H. Nuechterlein, Kenneth L. Subotnik, Joseph Ventura, Luana R. Turner, Michael J. Gitlin, Denise Gretchen-Doorly, Deborah R. Becker, Robert E. Drake, Charles J. Wallace, Robert P. Liberman
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- Journal:
- Psychological Medicine / Volume 50 / Issue 1 / January 2020
- Published online by Cambridge University Press:
- 04 January 2019, pp. 20-28
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Background
This study evaluated in a rigorous 18-month randomized controlled trial the efficacy of an enhanced vocational intervention for helping individuals with a recent first schizophrenia episode to return to and remain in competitive work or regular schooling.
MethodsIndividual Placement and Support (IPS) was adapted to meet the goals of individuals whose goals might involve either employment or schooling. IPS was combined with a Workplace Fundamentals Module (WFM) for an enhanced, outpatient, vocational intervention. Random assignment to the enhanced integrated rehabilitation program (N = 46) was contrasted with equally intensive clinical treatment at UCLA, including social skills training groups, and conventional vocational rehabilitation by state agencies (N = 23). All patients were provided case management and psychiatric services by the same clinical team and received oral atypical antipsychotic medication.
ResultsThe IPS–WFM combination led to 83% of patients participating in competitive employment or school in the first 6 months of intensive treatment, compared with 41% in the comparison group (p < 0.005). During the subsequent year, IPS–WFM continued to yield higher rates of schooling/employment (92% v. 60%, p < 0.03). Cumulative number of weeks of schooling and/or employment was also substantially greater with the IPS–WFM intervention (45 v. 26 weeks, p < 0.004).
ConclusionsThe results clearly support the efficacy of an enhanced intervention focused on recovery of participation in normative work and school settings in the initial phase of schizophrenia, suggesting potential for prevention of disability.
Overmedicating vulnerable children in the U.S
- Robert E. Drake
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- Journal:
- Epidemiology and Psychiatric Sciences / Volume 28 / Issue 4 / August 2019
- Published online by Cambridge University Press:
- 26 November 2018, pp. 358-359
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Community mental health in rural India: the Shifa project in Padhar Hospital, Madhya Pradesh
- Johann A. Ebenezer, Robert E. Drake
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- Journal:
- BJPsych International / Volume 15 / Issue 2 / May 2018
- Published online by Cambridge University Press:
- 12 March 2018, pp. 38-40
- Print publication:
- May 2018
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People with severe mental disorders in rural India have minimal access to mental health services. Project Shifa entails outreach to patients and families in 75 villages in rural central India. A team of local health workers led by one psychiatrist provide assessment, medications, education and follow-up services.
Foreword
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- By Robert E. Drake, Dartmouth Medical School, Lebanon, New Hampshire, USA
- Edited by Graham Thornicroft, { Author Role= exceeds the limit of 5 characters including spacing}, Michele Tansella, { Author Role= exceeds the limit of 5 characters including spacing}
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- Book:
- Mental Health Outcome Measures
- Published by:
- Royal College of Psychiatrists
- Published online:
- 25 February 2017, pp xiv-xiv
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Summary
Many different themes dominate the current literature on mental health services. Services should facilitate meaningful outcomes. The mission should be recovery. Interventions should be evidence based. Care should be client centred or self-directed. The mental health system should diminish stigma and foster social inclusion. Information technology should enhance efficiency. And many more! Each of these represents an endangered species. Why endangered? Simply put, philosophical movements easily become transient fads when they are not grounded in measures, numbers and data. Ideas, goals, guidelines, missions, benchmarks and plans require measurement to attain any hope of enduring reality. If nothing is measured, nothing changes. Instead, the next year brings a new commitment to yet another banner idea.
Mental health has long suffered from lack of measurement – a tradition extending back to the days when lack of measurement was valorised by clinicians who argued that the entire enterprise was too personal, ethereal or mystical to measure. Mental healthcare has, though, emerged from the dark ages. Although we still lack clear biological and physiological standards, measurement must be at the core of what we do. And measurement is no simple matter.
As the authors of the following chapters argue, measurement in mental health is serious and arduous work. We need measures that are reliable and valid, that address meaningful processes and outcomes, that uphold and reinforce our values, and that enhance rather than impede the enterprise of behavioural health. Developing, refining, testing, comparing and instantiating such measures are essential tasks if the field is to move forwards, rather than recycle old ideas in new terminology.
I commend the editors for their persistent efforts to encourage high-quality research. The chapters herein describe progress on many important fronts.
40K-40Ar age calibration of Late Miocene-Pliocene mammal-bearing Huayquerias and Tunuyan formations, Mendoza Province, Argentina
- Larry G. Marshall, Robert E. Drake, Garniss H. Curtis
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- Journal:
- Journal of Paleontology / Volume 60 / Issue 2 / March 1986
- Published online by Cambridge University Press:
- 19 May 2016, pp. 448-457
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Mineral separates of five tuffs interbedded in the mammal-bearing Huayquerías and Tunuyán formations in Mendoza Province, west-central Argentina, were dated by the 40K-40Ar method. At the locality of Rio Seco Ultima Aguada on the east side the Meseta Guadal three biotite concentrates of a tuff from a level that apparently corresponds to the very top of the Huayquerias Formation (or less probably to the very bottom of the Tunuyan Formation, sensu Dessanti, 1946) yielded an average age of 5.8 ± 0.1 Ma. The boundary between the Huayquerias Formation (namesake and type formation and fauna of the Huayquerian Land Mammal Age) and the Tunuyan Formation (which contains a Montehermosan age fauna at this locality) is thus about 5.8 Ma. At the locality of Rio Seco de la Salada on the west side of the Meseta Guadal, glass concentrates from two tuffs in the upper part of the Tunuyan Formation yielded ages of 2.6 ± 0.1 and 2.4 ± 0.3 Ma, respectively (the latter date is from a tuff located 90 m stratigraphically above the former). These dates indicate that the rocks and faunas from the upper part of the Tunuyan Formation are of Chapadmalalan (i.e., 2.8 to 2.5 Ma) and Uquian (i.e., 2.5 to 1.5 Ma) age. The faunas from the lower and middle parts of the Tunuyan Formation on the east side of the Meseta Guadal are apparently all of Montehermosan age (i.e., ca. 6.0 to 2.8 Ma).
Vertebrate paleontology, geology, and geochronology of the Tapera de López and Scarritt Pocket, Chubut Province, Argentina
- Larry G. Marshall, Richard L. Cifelli, Robert E. Drake, Garniss H. Curtis
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- Journal:
- Journal of Paleontology / Volume 60 / Issue 4 / July 1986
- Published online by Cambridge University Press:
- 14 July 2015, pp. 920-951
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Fossil land mammals were collected by G. G. Simpson in 1933–1934 at and near the Tapera de López in central Chubut Province, Patagonia, southern Argentina, from rocks now mapped as the Sarmiento Formation. These fossils are assigned to land mammal faunas of Casamayoran (Early Eocene), Mustersan (Middle Eocene), and Deseadan (late Early Oligocene through Early Miocene) age.
40K-40Ar age determinations of eight basalt and two tuff units associated with the Deseadan age local fauna at Scarritt Pocket establish a geochronologic framework that calibrates the biostratigraphic record at this locality. The radioisotope dates obtained at Scarritt Pocket range from 23.4 Ma to about 21.0 Ma, and equate with earliest Miocene time. The Scarritt Pocket local fauna is the youngest dated Deseadan age fauna yet known in South America.
Seven other localities have, or were reputed to have, local faunas of Deseadan age associated with dated volcanic units. Six of these localities are in Argentina (Gran Barranca, Cerro Blanco, Valle Hermoso, Pico Truncado, Cañadón Hondo, Quebrada Fiera de Malargüe) and one in Bolivia (Estratos Salla in the Salla-Luribay Basin). The stratigraphic relationships of the volcanic units with these local faunas is discussed, and the taxonomic content of each is reassessed.
The Deseadan Land Mammal Age is defined by the earliest record of the land mammal genus Pyrotherium, which is from below a basalt dated at 33.6 Ma at Pico Truncado. Other early records of Pyrotherium occur below basalts dated at about 29 Ma at the Gran Barranca and Valle Hermoso, and from a 28.5 Ma level of the Estratos Salla. Thus, the lower boundary for Deseadan time is about 34 Ma.
The youngest record of Pyrotherium is in the upper levels of the Estratos Salla dated at about 24 Ma. However, the Scarritt Pocket local fauna, which lacks Pyrotherium, permits placement of the upper boundary for Deseadan time at about 21.0 Ma. Late Deseadan time is surely, and the end of Deseadan time is apparently, marked by the last record of such groups as Proborhyaeninae (Proborhyaena), Rhynchippinae (Rhynchippus), Archaeohyracidae (Archaeohyrax), and the genera Platypittamys (Octodontidae), Scarrittia (Leontiniidae), Propachyrucos and Prohegetotherium (Hegetotheriidae), and Argyrohyrax (Interatheriidae), as these taxa are recorded in the Scarritt Pocket local fauna. Thus, Deseadan time extends from about 34.0 Ma to about 21.0 Ma, making it the Land Mammal Age with the longest known duration in South America.
Management of Substance Use Disorder in Schizophrenia Patients: Current Guidelines
- Robert E. Drake
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- Journal:
- CNS Spectrums / Volume 12 / Issue S17 / 2007
- Published online by Cambridge University Press:
- 07 November 2014, pp. 27-32
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Substance use disorder is the most frequent and clinically significant comorbidity among schizophrenia patients today. All schizophrenia patients should be assessed and monitored carefully regarding their substance use. Those with any regular use of alcohol or other drugs should be considered at risk for multiple adverse effects. As therapies for co-occurring substance use disorders have evolved over the past 20 years, medication management, psychosocial interventions, and rehabilitation models have increasingly emphasized the integration of mental health and substance abuse treatments, attention to group and residential interventions, matching interventions to stage of treatment, comprehensiveness, and long-term perspectives on recovery. Clinicians should understand the implications of each of these principles of care.
Contributors
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- By Rose Teteki Abbey, K. C. Abraham, David Tuesday Adamo, LeRoy H. Aden, Efrain Agosto, Victor Aguilan, Gillian T. W. Ahlgren, Charanjit Kaur AjitSingh, Dorothy B E A Akoto, Giuseppe Alberigo, Daniel E. Albrecht, Ruth Albrecht, Daniel O. Aleshire, Urs Altermatt, Anand Amaladass, Michael Amaladoss, James N. Amanze, Lesley G. Anderson, Thomas C. Anderson, Victor Anderson, Hope S. Antone, María Pilar Aquino, Paula Arai, Victorio Araya Guillén, S. Wesley Ariarajah, Ellen T. Armour, Brett Gregory Armstrong, Atsuhiro Asano, Naim Stifan Ateek, Mahmoud Ayoub, John Alembillah Azumah, Mercedes L. García Bachmann, Irena Backus, J. Wayne Baker, Mieke Bal, Lewis V. Baldwin, William Barbieri, António Barbosa da Silva, David Basinger, Bolaji Olukemi Bateye, Oswald Bayer, Daniel H. Bays, Rosalie Beck, Nancy Elizabeth Bedford, Guy-Thomas Bedouelle, Chorbishop Seely Beggiani, Wolfgang Behringer, Christopher M. Bellitto, Byard Bennett, Harold V. Bennett, Teresa Berger, Miguel A. Bernad, Henley Bernard, Alan E. Bernstein, Jon L. Berquist, Johannes Beutler, Ana María Bidegain, Matthew P. Binkewicz, Jennifer Bird, Joseph Blenkinsopp, Dmytro Bondarenko, Paulo Bonfatti, Riet en Pim Bons-Storm, Jessica A. Boon, Marcus J. Borg, Mark Bosco, Peter C. Bouteneff, François Bovon, William D. Bowman, Paul S. Boyer, David Brakke, Richard E. Brantley, Marcus Braybrooke, Ian Breward, Ênio José da Costa Brito, Jewel Spears Brooker, Johannes Brosseder, Nicholas Canfield Read Brown, Robert F. Brown, Pamela K. Brubaker, Walter Brueggemann, Bishop Colin O. Buchanan, Stanley M. Burgess, Amy Nelson Burnett, J. Patout Burns, David B. Burrell, David Buttrick, James P. Byrd, Lavinia Byrne, Gerado Caetano, Marcos Caldas, Alkiviadis Calivas, William J. Callahan, Salvatore Calomino, Euan K. Cameron, William S. Campbell, Marcelo Ayres Camurça, Daniel F. Caner, Paul E. Capetz, Carlos F. Cardoza-Orlandi, Patrick W. Carey, Barbara Carvill, Hal Cauthron, Subhadra Mitra Channa, Mark D. Chapman, James H. Charlesworth, Kenneth R. Chase, Chen Zemin, Luciano Chianeque, Philip Chia Phin Yin, Francisca H. Chimhanda, Daniel Chiquete, John T. Chirban, Soobin Choi, Robert Choquette, Mita Choudhury, Gerald Christianson, John Chryssavgis, Sejong Chun, Esther Chung-Kim, Charles M. A. Clark, Elizabeth A. Clark, Sathianathan Clarke, Fred Cloud, John B. Cobb, W. Owen Cole, John A Coleman, John J. Collins, Sylvia Collins-Mayo, Paul K. Conkin, Beth A. Conklin, Sean Connolly, Demetrios J. Constantelos, Michael A. Conway, Paula M. Cooey, Austin Cooper, Michael L. Cooper-White, Pamela Cooper-White, L. William Countryman, Sérgio Coutinho, Pamela Couture, Shannon Craigo-Snell, James L. Crenshaw, David Crowner, Humberto Horacio Cucchetti, Lawrence S. Cunningham, Elizabeth Mason Currier, Emmanuel Cutrone, Mary L. Daniel, David D. Daniels, Robert Darden, Rolf Darge, Isaiah Dau, Jeffry C. Davis, Jane Dawson, Valentin Dedji, John W. de Gruchy, Paul DeHart, Wendy J. Deichmann Edwards, Miguel A. De La Torre, George E. Demacopoulos, Thomas de Mayo, Leah DeVun, Beatriz de Vasconcellos Dias, Dennis C. Dickerson, John M. Dillon, Luis Miguel Donatello, Igor Dorfmann-Lazarev, Susanna Drake, Jonathan A. Draper, N. Dreher Martin, Otto Dreydoppel, Angelyn Dries, A. J. Droge, Francis X. D'Sa, Marilyn Dunn, Nicole Wilkinson Duran, Rifaat Ebied, Mark J. Edwards, William H. Edwards, Leonard H. Ehrlich, Nancy L. Eiesland, Martin Elbel, J. Harold Ellens, Stephen Ellingson, Marvin M. Ellison, Robert Ellsberg, Jean Bethke Elshtain, Eldon Jay Epp, Peter C. Erb, Tassilo Erhardt, Maria Erling, Noel Leo Erskine, Gillian R. Evans, Virginia Fabella, Michael A. Fahey, Edward Farley, Margaret A. Farley, Wendy Farley, Robert Fastiggi, Seena Fazel, Duncan S. Ferguson, Helwar Figueroa, Paul Corby Finney, Kyriaki Karidoyanes FitzGerald, Thomas E. FitzGerald, John R. Fitzmier, Marie Therese Flanagan, Sabina Flanagan, Claude Flipo, Ronald B. Flowers, Carole Fontaine, David Ford, Mary Ford, Stephanie A. Ford, Jim Forest, William Franke, Robert M. Franklin, Ruth Franzén, Edward H. Friedman, Samuel Frouisou, Lorelei F. Fuchs, Jojo M. Fung, Inger Furseth, Richard R. Gaillardetz, Brandon Gallaher, China Galland, Mark Galli, Ismael García, Tharscisse Gatwa, Jean-Marie Gaudeul, Luis María Gavilanes del Castillo, Pavel L. Gavrilyuk, Volney P. Gay, Metropolitan Athanasios Geevargis, Kondothra M. George, Mary Gerhart, Simon Gikandi, Maurice Gilbert, Michael J. Gillgannon, Verónica Giménez Beliveau, Terryl Givens, Beth Glazier-McDonald, Philip Gleason, Menghun Goh, Brian Golding, Bishop Hilario M. Gomez, Michelle A. Gonzalez, Donald K. Gorrell, Roy Gottfried, Tamara Grdzelidze, Joel B. Green, Niels Henrik Gregersen, Cristina Grenholm, Herbert Griffiths, Eric W. Gritsch, Erich S. Gruen, Christoffer H. Grundmann, Paul H. Gundani, Jon P. Gunnemann, Petre Guran, Vidar L. Haanes, Jeremiah M. Hackett, Getatchew Haile, Douglas John Hall, Nicholas Hammond, Daphne Hampson, Jehu J. Hanciles, Barry Hankins, Jennifer Haraguchi, Stanley S. Harakas, Anthony John Harding, Conrad L. Harkins, J. William Harmless, Marjory Harper, Amir Harrak, Joel F. Harrington, Mark W. Harris, Susan Ashbrook Harvey, Van A. Harvey, R. Chris Hassel, Jione Havea, Daniel Hawk, Diana L. Hayes, Leslie Hayes, Priscilla Hayner, S. Mark Heim, Simo Heininen, Richard P. Heitzenrater, Eila Helander, David Hempton, Scott H. Hendrix, Jan-Olav Henriksen, Gina Hens-Piazza, Carter Heyward, Nicholas J. Higham, David Hilliard, Norman A. Hjelm, Peter C. Hodgson, Arthur Holder, M. Jan Holton, Dwight N. Hopkins, Ronnie Po-chia Hsia, Po-Ho Huang, James Hudnut-Beumler, Jennifer S. Hughes, Leonard M. Hummel, Mary E. Hunt, Laennec Hurbon, Mark Hutchinson, Susan E. Hylen, Mary Beth Ingham, H. Larry Ingle, Dale T. Irvin, Jon Isaak, Paul John Isaak, Ada María Isasi-Díaz, Hans Raun Iversen, Margaret C. Jacob, Arthur James, Maria Jansdotter-Samuelsson, David Jasper, Werner G. Jeanrond, Renée Jeffery, David Lyle Jeffrey, Theodore W. Jennings, David H. Jensen, Robin Margaret Jensen, David Jobling, Dale A. Johnson, Elizabeth A. Johnson, Maxwell E. Johnson, Sarah Johnson, Mark D. Johnston, F. Stanley Jones, James William Jones, John R. Jones, Alissa Jones Nelson, Inge Jonsson, Jan Joosten, Elizabeth Judd, Mulambya Peggy Kabonde, Robert Kaggwa, Sylvester Kahakwa, Isaac Kalimi, Ogbu U. Kalu, Eunice Kamaara, Wayne C. Kannaday, Musimbi Kanyoro, Veli-Matti Kärkkäinen, Frank Kaufmann, Léon Nguapitshi Kayongo, Richard Kearney, Alice A. Keefe, Ralph Keen, Catherine Keller, Anthony J. Kelly, Karen Kennelly, Kathi Lynn Kern, Fergus Kerr, Edward Kessler, George Kilcourse, Heup Young Kim, Kim Sung-Hae, Kim Yong-Bock, Kim Yung Suk, Richard King, Thomas M. King, Robert M. Kingdon, Ross Kinsler, Hans G. Kippenberg, Cheryl A. Kirk-Duggan, Clifton Kirkpatrick, Leonid Kishkovsky, Nadieszda Kizenko, Jeffrey Klaiber, Hans-Josef Klauck, Sidney Knight, Samuel Kobia, Robert Kolb, Karla Ann Koll, Heikki Kotila, Donald Kraybill, Philip D. W. Krey, Yves Krumenacker, Jeffrey Kah-Jin Kuan, Simanga R. Kumalo, Peter Kuzmic, Simon Shui-Man Kwan, Kwok Pui-lan, André LaCocque, Stephen E. Lahey, John Tsz Pang Lai, Emiel Lamberts, Armando Lampe, Craig Lampe, Beverly J. Lanzetta, Eve LaPlante, Lizette Larson-Miller, Ariel Bybee Laughton, Leonard Lawlor, Bentley Layton, Robin A. Leaver, Karen Lebacqz, Archie Chi Chung Lee, Marilyn J. Legge, Hervé LeGrand, D. L. LeMahieu, Raymond Lemieux, Bill J. Leonard, Ellen M. Leonard, Outi Leppä, Jean Lesaulnier, Nantawan Boonprasat Lewis, Henrietta Leyser, Alexei Lidov, Bernard Lightman, Paul Chang-Ha Lim, Carter Lindberg, Mark R. Lindsay, James R. Linville, James C. Livingston, Ann Loades, David Loades, Jean-Claude Loba-Mkole, Lo Lung Kwong, Wati Longchar, Eleazar López, David W. Lotz, Andrew Louth, Robin W. Lovin, William Luis, Frank D. Macchia, Diarmaid N. J. MacCulloch, Kirk R. MacGregor, Marjory A. MacLean, Donald MacLeod, Tomas S. Maddela, Inge Mager, Laurenti Magesa, David G. Maillu, Fortunato Mallimaci, Philip Mamalakis, Kä Mana, Ukachukwu Chris Manus, Herbert Robinson Marbury, Reuel Norman Marigza, Jacqueline Mariña, Antti Marjanen, Luiz C. L. Marques, Madipoane Masenya (ngwan'a Mphahlele), Caleb J. D. Maskell, Steve Mason, Thomas Massaro, Fernando Matamoros Ponce, András Máté-Tóth, Odair Pedroso Mateus, Dinis Matsolo, Fumitaka Matsuoka, John D'Arcy May, Yelena Mazour-Matusevich, Theodore Mbazumutima, John S. McClure, Christian McConnell, Lee Martin McDonald, Gary B. McGee, Thomas McGowan, Alister E. McGrath, Richard J. McGregor, John A. McGuckin, Maud Burnett McInerney, Elsie Anne McKee, Mary B. McKinley, James F. McMillan, Ernan McMullin, Kathleen E. McVey, M. Douglas Meeks, Monica Jyotsna Melanchthon, Ilie Melniciuc-Puica, Everett Mendoza, Raymond A. Mentzer, William W. Menzies, Ina Merdjanova, Franziska Metzger, Constant J. Mews, Marvin Meyer, Carol Meyers, Vasile Mihoc, Gunner Bjerg Mikkelsen, Maria Inêz de Castro Millen, Clyde Lee Miller, Bonnie J. Miller-McLemore, Alexander Mirkovic, Paul Misner, Nozomu Miyahira, R. W. L. Moberly, Gerald Moede, Aloo Osotsi Mojola, Sunanda Mongia, Rebeca Montemayor, James Moore, Roger E. Moore, Craig E. Morrison O.Carm, Jeffry H. Morrison, Keith Morrison, Wilson J. Moses, Tefetso Henry Mothibe, Mokgethi Motlhabi, Fulata Moyo, Henry Mugabe, Jesse Ndwiga Kanyua Mugambi, Peggy Mulambya-Kabonde, Robert Bruce Mullin, Pamela Mullins Reaves, Saskia Murk Jansen, Heleen L. Murre-Van den Berg, Augustine Musopole, Isaac M. T. Mwase, Philomena Mwaura, Cecilia Nahnfeldt, Anne Nasimiyu Wasike, Carmiña Navia Velasco, Thulani Ndlazi, Alexander Negrov, James B. Nelson, David G. Newcombe, Carol Newsom, Helen J. Nicholson, George W. E. Nickelsburg, Tatyana Nikolskaya, Damayanthi M. A. Niles, Bertil Nilsson, Nyambura Njoroge, Fidelis Nkomazana, Mary Beth Norton, Christian Nottmeier, Sonene Nyawo, Anthère Nzabatsinda, Edward T. Oakes, Gerald O'Collins, Daniel O'Connell, David W. Odell-Scott, Mercy Amba Oduyoye, Kathleen O'Grady, Oyeronke Olajubu, Thomas O'Loughlin, Dennis T. Olson, J. Steven O'Malley, Cephas N. Omenyo, Muriel Orevillo-Montenegro, César Augusto Ornellas Ramos, Agbonkhianmeghe E. Orobator, Kenan B. Osborne, Carolyn Osiek, Javier Otaola Montagne, Douglas F. Ottati, Anna May Say Pa, Irina Paert, Jerry G. Pankhurst, Aristotle Papanikolaou, Samuele F. Pardini, Stefano Parenti, Peter Paris, Sung Bae Park, Cristián G. Parker, Raquel Pastor, Joseph Pathrapankal, Daniel Patte, W. Brown Patterson, Clive Pearson, Keith F. Pecklers, Nancy Cardoso Pereira, David Horace Perkins, Pheme Perkins, Edward N. Peters, Rebecca Todd Peters, Bishop Yeznik Petrossian, Raymond Pfister, Peter C. Phan, Isabel Apawo Phiri, William S. F. Pickering, Derrick G. Pitard, William Elvis Plata, Zlatko Plese, John Plummer, James Newton Poling, Ronald Popivchak, Andrew Porter, Ute Possekel, James M. Powell, Enos Das Pradhan, Devadasan Premnath, Jaime Adrían Prieto Valladares, Anne Primavesi, Randall Prior, María Alicia Puente Lutteroth, Eduardo Guzmão Quadros, Albert Rabil, Laurent William Ramambason, Apolonio M. Ranche, Vololona Randriamanantena Andriamitandrina, Lawrence R. Rast, Paul L. Redditt, Adele Reinhartz, Rolf Rendtorff, Pål Repstad, James N. Rhodes, John K. Riches, Joerg Rieger, Sharon H. Ringe, Sandra Rios, Tyler Roberts, David M. Robinson, James M. Robinson, Joanne Maguire Robinson, Richard A. H. Robinson, Roy R. Robson, Jack B. Rogers, Maria Roginska, Sidney Rooy, Rev. Garnett Roper, Maria José Fontelas Rosado-Nunes, Andrew C. Ross, Stefan Rossbach, François Rossier, John D. Roth, John K. Roth, Phillip Rothwell, Richard E. Rubenstein, Rosemary Radford Ruether, Markku Ruotsila, John E. Rybolt, Risto Saarinen, John Saillant, Juan Sanchez, Wagner Lopes Sanchez, Hugo N. Santos, Gerhard Sauter, Gloria L. Schaab, Sandra M. Schneiders, Quentin J. Schultze, Fernando F. Segovia, Turid Karlsen Seim, Carsten Selch Jensen, Alan P. F. Sell, Frank C. Senn, Kent Davis Sensenig, Damían Setton, Bal Krishna Sharma, Carolyn J. Sharp, Thomas Sheehan, N. Gerald Shenk, Christian Sheppard, Charles Sherlock, Tabona Shoko, Walter B. Shurden, Marguerite Shuster, B. Mark Sietsema, Batara Sihombing, Neil Silberman, Clodomiro Siller, Samuel Silva-Gotay, Heikki Silvet, John K. Simmons, Hagith Sivan, James C. Skedros, Abraham Smith, Ashley A. Smith, Ted A. Smith, Daud Soesilo, Pia Søltoft, Choan-Seng (C. S.) Song, Kathryn Spink, Bryan Spinks, Eric O. Springsted, Nicolas Standaert, Brian Stanley, Glen H. Stassen, Karel Steenbrink, Stephen J. Stein, Andrea Sterk, Gregory E. Sterling, Columba Stewart, Jacques Stewart, Robert B. Stewart, Cynthia Stokes Brown, Ken Stone, Anne Stott, Elizabeth Stuart, Monya Stubbs, Marjorie Hewitt Suchocki, David Kwang-sun Suh, Scott W. Sunquist, Keith Suter, Douglas Sweeney, Charles H. Talbert, Shawqi N. Talia, Elsa Tamez, Joseph B. Tamney, Jonathan Y. Tan, Yak-Hwee Tan, Kathryn Tanner, Feiya Tao, Elizabeth S. Tapia, Aquiline Tarimo, Claire Taylor, Mark Lewis Taylor, Bishop Abba Samuel Wolde Tekestebirhan, Eugene TeSelle, M. Thomas Thangaraj, David R. Thomas, Andrew Thornley, Scott Thumma, Marcelo Timotheo da Costa, George E. “Tink” Tinker, Ola Tjørhom, Karen Jo Torjesen, Iain R. Torrance, Fernando Torres-Londoño, Archbishop Demetrios [Trakatellis], Marit Trelstad, Christine Trevett, Phyllis Trible, Johannes Tromp, Paul Turner, Robert G. Tuttle, Archbishop Desmond Tutu, Peter Tyler, Anders Tyrberg, Justin Ukpong, Javier Ulloa, Camillus Umoh, Kristi Upson-Saia, Martina Urban, Monica Uribe, Elochukwu Eugene Uzukwu, Richard Vaggione, Gabriel Vahanian, Paul Valliere, T. J. Van Bavel, Steven Vanderputten, Peter Van der Veer, Huub Van de Sandt, Louis Van Tongeren, Luke A. Veronis, Noel Villalba, Ramón Vinke, Tim Vivian, David Voas, Elena Volkova, Katharina von Kellenbach, Elina Vuola, Timothy Wadkins, Elaine M. Wainwright, Randi Jones Walker, Dewey D. Wallace, Jerry Walls, Michael J. Walsh, Philip Walters, Janet Walton, Jonathan L. Walton, Wang Xiaochao, Patricia A. Ward, David Harrington Watt, Herold D. Weiss, Laurence L. Welborn, Sharon D. Welch, Timothy Wengert, Traci C. West, Merold Westphal, David Wetherell, Barbara Wheeler, Carolinne White, Jean-Paul Wiest, Frans Wijsen, Terry L. Wilder, Felix Wilfred, Rebecca Wilkin, Daniel H. Williams, D. Newell Williams, Michael A. Williams, Vincent L. Wimbush, Gabriele Winkler, Anders Winroth, Lauri Emílio Wirth, James A. Wiseman, Ebba Witt-Brattström, Teofil Wojciechowski, John Wolffe, Kenman L. Wong, Wong Wai Ching, Linda Woodhead, Wendy M. Wright, Rose Wu, Keith E. Yandell, Gale A. Yee, Viktor Yelensky, Yeo Khiok-Khng, Gustav K. K. Yeung, Angela Yiu, Amos Yong, Yong Ting Jin, You Bin, Youhanna Nessim Youssef, Eliana Yunes, Robert Michael Zaller, Valarie H. Ziegler, Barbara Brown Zikmund, Joyce Ann Zimmerman, Aurora Zlotnik, Zhuo Xinping
- Edited by Daniel Patte, Vanderbilt University, Tennessee
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- The Cambridge Dictionary of Christianity
- Published online:
- 05 August 2012
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- 20 September 2010, pp xi-xliv
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Foreword
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- By Robert E. Drake, Andrew Thomson Professor of Psychiatry Dartmouth Medical School, Lebanon, New Hampshire, USA
- Edited by Graham Thornicroft, Michelle Tansella
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- Mental Health Outcome Measures
- Published online:
- 02 January 2018
- Print publication:
- 01 September 2010, pp xiv-xiv
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Summary
Many different themes dominate the current literature on mental health services. Services should facilitate meaningful outcomes. The mission should be recovery. Interventions should be evidence based. Care should be client centred or self-directed. The mental health system should diminish stigma and foster social inclusion. Information technology should enhance efficiency. And many more! Each of these represents an endangered species. Why endangered? Simply put, philosophical movements easily become transient fads when they are not grounded in measures, numbers and data. Ideas, goals, guidelines, missions, benchmarks and plans require measurement to attain any hope of enduring reality. If nothing is measured, nothing changes. Instead, the next year brings a new commitment to yet another banner idea.
Mental health has long suffered from lack of measurement – a tradition extending back to the days when lack of measurement was valorised by clinicians who argued that the entire enterprise was too personal, ethereal or mystical to measure. Mental healthcare has, though, emerged from the dark ages. Although we still lack clear biological and physiological standards, measurement must be at the core of what we do. And measurement is no simple matter.
As the authors of the following chapters argue, measurement in mental health is serious and arduous work. We need measures that are reliable and valid, that address meaningful processes and outcomes, that uphold and reinforce our values, and that enhance rather than impede the enterprise of behavioural health. Developing, refining, testing, comparing and instantiating such measures are essential tasks if the field is to move forwards, rather than recycle old ideas in new terminology.
I commend the editors for their persistent efforts to encourage highquality research. The chapters herein describe progress on many important fronts.
Detection of peptidases in Trypanosoma cruzi epimastigotes using chromogenic and fluorogenic substrates
- N. Healy, S. Greig, H. Enahoro, H. Roberts, L. Drake, E. Shaw, F. Ashall
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- Parasitology / Volume 104 / Issue 2 / April 1992
- Published online by Cambridge University Press:
- 06 April 2009, pp. 315-322
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Detergent extracts of Trypanosoma cruzi epimastigotes catalysed the hydrolysis of a range of amino-acyl and peptidyl p-nitro-anilides and aminomethylcoumarins. At least three enzymes were detected that cleave Z–Phe–Arg–MCA. Two of these were optimally active at alkaline pH, the other at pH 4·0. Of the two enzymes with alkaline pH optima, one was a cysteine peptidase and was unable to cleave Bz–Arg–MCA readily, whilst the other cleaved Bz–Arg–MCA and was inhibited by diisopropyl fluorophosphate. The acidic enzyme was similar to cathespin L of other eukayrotes with respect to its pH profile, substrate-specificity and inhibitor-sensitivity. Evidence was presented that epimastigotes contain a cysteine-type dipeptidyl aminopeptidase, one or more aminopeptidases, and a serine peptidase that cleaves Boc–Ala–Ala–pNA. Digitonin solubilization of the activities from cells supports the hypothesis that the cathespin L-like enzyme and the dipeptidyl aminopeptidase are lysosomal, whilst the Bz–Arg–MCA hydrolase, the aminopeptidases and the Boc–Ala–Ala–pNA serine peptidase are cytosolic.
Predictors of employment for people with severe mental illness: results of an international six-centre randomised controlled trial
- Jocelyn Catty, Pascale Lissouba, Sarah White, Thomas Becker, Robert E. Drake, Angelo Fioritti, Martin Knapp, Christoph Lauber, Wulf Rössler, Toma Tomov, Jooske van Busschbach, Durk Wiersma, Tom Burns, EQOLISE Group
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- Journal:
- The British Journal of Psychiatry / Volume 192 / Issue 3 / March 2008
- Published online by Cambridge University Press:
- 02 January 2018, pp. 224-231
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- March 2008
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Background
An international six-centre randomised controlled trial comparing individual placement and support (IPS) with usual vocational rehabilitation for people with serious mental illness found IPS to be more effective for all vocational outcomes.
AimsTo determine which patients with severe mental illness do well in vocational services and which process and service factors are associated with better outcomes.
MethodPatient characteristics and early process variables were tested as predictors of employment outcomes. Service characteristics were explored as predictors of the effectiveness of IPS.
ResultsPatients with previous work history, fewer met social needs and better relationships with their vocational workers were more likely to obtain employment and work for longer. Remission and swifter service uptake were associated with working more. Having an IPS service closer to the original IPS model was the only service characteristic associated with greater effectiveness.
ConclusionsThe IPS service was found to be more effective for all vocational outcomes. In addition, maintaining high IPS fidelity and targeting relational skills would be a valuable focus for all vocational interventions, leading to improved employment outcomes. Motivation to find work may be decreased by satisfaction with current life circumstances.
DMP III: Pleistocene and Holocene palaeonvironments and prehistoric occupation of Fazzan, Libyan Sahara
- Marta Mirazón Lahr, Robert Foley, Simon Armitage, Huw Barton, Federica Crivellaro, Nicholas Drake, Mark Hounslow, Lisa Maher, David Mattingly, Mustapha Salem, Jay Stock, Kevin White
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- Journal:
- Libyan Studies / Volume 39 / 2008
- Published online by Cambridge University Press:
- 03 March 2015, pp. 263-294
- Print publication:
- 2008
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The palaeoanthropological and geomorphological sub-projects of the Desert Migrations Project (DMP) focus on the Pleistocene and early Holocene environment and prehistory of Fazzan so as to assess the timing and extent of hominin and human movement across the Sahara through time. This paper reports on the findings of the 2008 field season, with a focus on the prehistoric evidence along the northern margin of the Ubari sand sea.
The geomorphological record of the area preserves evidence of at least five past episodes of lake formation. The exact chronology of these, as well as the spatial extent of these lakes, remains the focus of further study.
The archaeological record of hominin and human occupation of Fazzan prior to the establishment of the Garamantian civilisation is extraordinarily rich. Between 2007 and 2008, the DMP palaeoanthropological project surveyed thirty-five localities along the northern margin of the Ubari sand sea, recording a range of assemblages spanning all Palaeolithic industries. Most of the archaeological remains found consisted of stone-tools, while grinding stones were comparatively restricted geographically. Mode 1/Oldowan tools were found at two localities, contrasting with the widespread presence of Mode 2/Acheulean, Mode 3/Middle Stone Age and Mode 5/microlithic artefacts. This indicates that, although hominin presence in the area is probably earlier than previously thought, populations were comparatively sparse until the Middle Pleistocene. Twenty-one localities within the Ubari sand sea, as well as seven south of the Messak Settafet were also surveyed between 2007 and 2008. The detailed study of the lithics from these areas will be carried out next year, but preliminary results stress the different nature of the assemblages found within interdune corridors — very low frequency of cores, no Mode 1 and extremely rare Mode 2 lithics (found at a single locality).
The 2009 field season will focus on obtaining further samples of palaeolake sediments for dating, on the evidence of Mode 1 assemblages south of the Messak, as well as on the refining of the archaeological indicators that may distinguish the different phases of hominin and human occupation of Fazzan during the Later Pleistocene and Holocene.
Stability of early-phase primary psychotic disorders with concurrent substance use and substance-induced psychosis
- Carol L. M. Caton, Deborah S. Hasin, Patrick E. Shrout, Robert E. Drake, Boanerges Domínguez, Michael B. First, Sharon Samet, Bella Schanzer
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- Journal:
- The British Journal of Psychiatry / Volume 190 / Issue 2 / February 2007
- Published online by Cambridge University Press:
- 02 January 2018, pp. 105-111
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- February 2007
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Background
The stability of the diagnostic distinction between a substance-induced psychosis and a primary psychotic disorder co-occurring with substance use is not established.
AimsTo describe DSM – IV diagnostic changes over 1 year and determine the predictive validity of baseline indicators of the substance-induced psychosis v. primary psychosis distinction.
MethodWe conducted a 1-year follow-up study of 319 psychiatric emergency department admissions with diagnoses of early-phase psychosis and substance use comorbidity.
ResultsOf those with a baseline DSM—IV diagnosis of substance-induced psychosis, 25% had a diagnosis of primary psychosis at follow-up. These patients had poorer premorbid functioning, less insight into psychosis and greater family mental illness than patients with a stable diagnosis of substance-induced psychosis. Reclassifying change cases to primary psychoses on follow-up, key baseline predictors of the primary/substance-induced distinction at 1 year also included greater family history of mental illness in the primary psychosis group.
ConclusionsFurther study of substance-induced psychoses should employ neuroscientific and behavioural approaches. Study findings can guide more accurate diagnoses at first treatment.
Desert Migrations: people, environment and culture in the Libyan Sahara
- David Mattingly, Marta Lahr, Simon Armitage, Huw Barton, John Dore, Nick Drake, Robert Foley, Stefania Merlo, Mustapha Salem, Jay Stock, Kevin White, Muftah Ahmed, Franca Cole, Federica Crivellaro, Mireya Gonzalez Rodriguez, Maria Guagnin, Sebastian Jones, Vassil Karloukovski, Victoria Leitch, Lisa Maher, Farès Moussa, Anita Radini, Ian Reeds, Toby Savage, Martin Sterry
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- Journal:
- Libyan Studies / Volume 38 / 2007
- Published online by Cambridge University Press:
- 03 March 2015, pp. 115-156
- Print publication:
- 2007
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The Desert Migrations Project is a new interdisciplinary and multi-dimensional collaborative project between the Society for Libyan Studies and the Department of Antiquities. The geographical focus of the study is the Fazzan region of southwest Libya and in thematic terms we aim to address the theme of migration in the broadest sense, encompassing the movement of people, ideas/knowledge and material culture into and out of Fazzan, along with evidence of shifting climatic and ecological boundaries over time. The report describes the principal sub-strands of the project's first season in January 2007, with some account of research questions, methods employed and some preliminary results. Three main sub-projects are reported on. The first concerns the improved understanding of long-term climatic and environmental changes derived from a detailed palaeoenvironmental study of palaeolake sediments. This geo-science work runs alongside and feeds directly into both archaeological sub-projects, the first relating to prehistoric activity and mobility around and between a series of palaeolakes during wetter climatic cycles; the second to the excavation of burials in the Wadi al-Ajal, exploring the changing relationship between material culture, identity and ethnicity across time, from prehistory to the early Islamic period (the span of the main cemetery zones). In addition, some rock art research and a survey of historic period sites was undertaken in the Wadi ash-Shati and Ubari sand sea.
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